Search Results - "Kitai, Yuichi"

DNA-Containing Exosomes Derived from Cancer Cells Treated with Topotecan Activate a STING-Dependent Pathway and Reinforce Antitumor Immunity by Kitai, Yuichi, Kawasaki, Takumi, Sueyoshi, Takuya, Kobiyama, Kouji, Ishii, Ken J, Zou, Jian, Akira, Shizuo, Matsuda, Tadashi, Kawai, Taro

“…Danger-associated molecular patterns derived from damaged or dying cells elicit inflammation and potentiate antitumor immune responses. In this article, we…”
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IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes by Muromoto, Ryuta, Hirao, Toru, Tawa, Keisuke, Hirashima, Koki, Kon, Shigeyuki, Kitai, Yuichi, Matsuda, Tadashi

“…In psoriasis lesions, a diverse mixture of cytokines is up-regulated that influence each other generating a complex inflammatory situation. Although this is…”
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Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2 by Sueyoshi, Takuya, Kawasaki, Takumi, Kitai, Yuichi, Ori, Daisuke, Akira, Shizuo, Kawai, Taro

“…Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), RIG-I, and melanoma differentiation-associated gene 5 (MDA5) play a critical role in inducing…”
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Intravesicular Acidification Regulates Lipopolysaccharide Inflammation and Tolerance through TLR4 Trafficking by Murase, Motoya, Kawasaki, Takumi, Hakozaki, Rika, Sueyoshi, Takuya, Putri, Dyaningtyas Dewi Pamungkas, Kitai, Yuichi, Sato, Shintaro, Ikawa, Masahito, Kawai, Taro

“…TLRs recognize pathogen components and drive innate immune responses. They localize at either the plasma membrane or intracellular vesicles such as endosomes…”
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Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis by Sasaki, Yuto, Saitoh, Kodai, Kagohashi, Kota, Kitai, Yuichi, Muromoto, Ryuta, Oritani, Kenji, Kashiwakura, Jun-ichi, Matsuda, Tadashi

“…Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein involved in inflammatory and immune responses, such as inflammatory bowel disease and…”
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Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML by Toda, Jun, Ichii, Michiko, Oritani, Kenji, Shibayama, Hirohiko, Tanimura, Akira, Saito, Hideaki, Yokota, Takafumi, Motooka, Daisuke, Okuzaki, Daisuke, Kitai, Yuichi, Muromoto, Ryuta, Kashiwakura, Jun-ichi, Matsuda, Tadashi, Hosen, Naoki, Kanakura, Yuzuru

“…The family of signal-transducing adapter proteins (STAPs) has been reported to be involved in a variety of intracellular signaling pathways and implicated as…”
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Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice by Kashiwakura, Jun-ichi, Yoshihara, Mari, Saitoh, Kodai, Kagohashi, Kota, Sasaki, Yuto, Kobayashi, Fuki, Inagaki, Iori, Kitai, Yuichi, Muromoto, Ryuta, Matsuda, Tadashi

“…Propolis is a resinous mixture produced by honey bees that contains cinnamic acid derivatives and flavonoids. Although propolis has been reported to inhibit…”
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STAP-2 Is a Novel Positive Regulator of TCR-Proximal Signals by Saitoh, Kodai, Kashiwakura, Jun-ichi, Kagohashi, Kota, Sasaki, Yuto, Kawahara, Shoya, Sekine, Yuichi, Kitai, Yuichi, Muromoto, Ryuta, Ichii, Michiko, Nakatsukasa, Hiroko, Yoshimura, Akihiko, Oritani, Kenji, Matsuda, Tadashi

“…Abstract TCR ligation with an Ag presented on MHC molecules promotes T cell activation, leading to the selection, differentiation, and proliferation of T cells…”
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A peptide derived from adaptor protein STAP-2 inhibits tumor progression by downregulating epidermal growth factor receptor signaling by Maemoto, Taiga, Kitai, Yuichi, Takahashi, Runa, Shoji, Haruka, Yamada, Shunsuke, Takei, Shiho, Ito, Daiki, Muromoto, Ryuta, Kashiwakura, Jun-ichi, Handa, Haruka, Hashimoto, Ari, Hashimoto, Shigeru, Ose, Toyoyuki, Oritani, Kenji, Matsuda, Tadashi

“…Signal-transducing adaptor family member-2 (STAP-2) is an adaptor protein that regulates various intracellular signals. We previously demonstrated that STAP-2…”
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STAP-2-Derived Peptide Suppresses TCR-Mediated Signals to Initiate Immune Responses by Sasaki, Yuto, Saitoh, Kodai, Kagohashi, Kota, Ose, Toyoyuki, Kawahara, Shoya, Kitai, Yuichi, Muromoto, Ryuta, Sekine, Yuichi, Ichii, Michiko, Yoshimura, Akihiko, Oritani, Kenji, Kashiwakura, Jun-Ichi, Matsuda, Tadashi

“…Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that contains pleckstrin and Src homology 2-like domains, as well as a proline-rich region…”
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Central Roles of STAT3-Mediated Signals in Onset and Development of Cancers: Tumorigenesis and Immunosurveillance by Hashimoto, Shigeru, Hashimoto, Ari, Muromoto, Ryuta, Kitai, Yuichi, Oritani, Kenji, Matsuda, Tadashi

“…Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-associated inflammation contributes to tumor initiation and…”
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Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells by Kashiwakura, Jun-Ichi, Saitoh, Kodai, Ihara, Takeru, Sasaki, Yuto, Kagohashi, Kota, Enohara, Shiyo, Morioka, Yuka, Watarai, Hiroshi, Muromoto, Ryuta, Kitai, Yuichi, Iwabuchi, Kazuya, Oritani, Kenji, Matsuda, Tadashi

“…Signal-transducing adaptor protein (STAP) family members function as adaptor molecules and are involved in several events during immune responses. Notably…”
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A novel intramolecular negative regulation of mouse Jak3 activity by tyrosine 820 by Sekine, Yuichi, Kikkawa, Kazuna, Witthuhn, Bruce A, Kashiwakura, Jun-ichi, Muromoto, Ryuta, Kitai, Yuichi, Fujimuro, Masahiro, Oritani, Kenji, Matsuda, Tadashi

“…Abstract Jak3, a member of the Janus kinase family, is essential for the cytokine receptor common gamma chain (γc)-mediated signaling. During activation of…”
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CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation by Kitai, Yuichi, Ishiura, Marie, Saitoh, Kodai, Matsumoto, Naoki, Owashi, Kimiya, Yamada, Shunsuke, Muromoto, Ryuta, Kashiwakura, Jun-ichi, Oritani, Kenji, Matsuda, Tadashi

“…Abstract CD47, a 50 kDa transmembrane protein, facilitates integrin-mediated cell adhesion and inhibits cell engulfment by phagocytes. Since CD47 blocking…”
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Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress by Ichii, Michiko, Oritani, Kenji, Toda, Jun, Saito, Hideaki, Shi, Henyun, Shibayama, Hirohiko, Motooka, Daisuke, Kitai, Yuichi, Muromoto, Ryuta, Kashiwakura, Jun-Ichi, Saitoh, Kodai, Okuzaki, Daisuke, Matsuda, Tadashi, Kanakura, Yuzuru

“…Signal-transducing adaptor protein-2 (STAP-2) was discovered as a C-FMS/M-CSFR interacting protein and subsequently found to function as an adaptor of…”
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A Novel α9 Integrin Ligand, XCL1/Lymphotactin, Is Involved in the Development of Murine Models of Autoimmune Diseases by Matsumoto, Naoki, Kon, Shigeyuki, Nakatsuru, Takuya, Miyashita, Tomoe, Inui, Kyosuke, Saitoh, Kodai, Kitai, Yuichi, Muromoto, Ryuta, Kashiwakura, Jun-Ichi, Uede, Toshimitsu, Matsuda, Tadashi

“…The integrin α9β1 is a key receptor involved in the development of autoimmune diseases. However, the detailed mechanism for the association of α9β1 integrin…”
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Correction: Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells by Kashiwakura, Jun-Ichi, Saitoh, Kodai, Ihara, Takeru, Sasaki, Yuto, Kagohashi, Kota, Enohara, Shiyo, Morioka, Yuka, Watarai, Hiroshi, Muromoto, Ryuta, Kitai, Yuichi, Iwabuchi, Kazuya, Oritani, Kenji, Matsuda, Tadashi

“…[This corrects the article DOI: 10.1371/journal.pone.0241440.]…”
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Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications by Maemoto, Taiga, Sasaki, Yuto, Okuyama, Fumiya, Kitai, Yuichi, Oritani, Kenji, Matsuda, Tadashi

“…Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that…”
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STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions by Kashiwakura, Jun-Ichi, Yamashita, Shinsuke, Yoshihara, Mari, Inui, Kyosuke, Saitoh, Kodai, Sekine, Yuichi, Muromoto, Ryuta, Kitai, Yuichi, Oritani, Kenji, Matsuda, Tadashi

“…Basophils are an important cell type in the regulation of Th2 immune responses. Recently, we revealed that signal-transducing adaptor protein-2 (STAP-2)…”
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Roles of cell division control factor SdiA: recognition of quorum sensing signals and modulation of transcription regulation targets by Shimada, Tomohiro, Shimada, Kaori, Matsui, Makoto, Kitai, Yuichi, Igarashi, Jun, Suga, Hiroaki, Ishihama, Akira

“…In Gram‐negative bacteria, N‐acylhomoserine lactone (HSL) is used as a signal in cell–cell communication and quorum sensing (QS). The model prokaryote…”
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