Search Results - "Kita, Aya"
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Broad spectrum and potent antitumor activities of YM155, a novel small‐molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models
Published in Cancer science (01-03-2011)“…Antitumor activities of YM155, a novel small‐molecule survivin suppressant, were investigated in a wide variety of human cancer cell lines and xenograft…”
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2
YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts
Published in Cancer research (Chicago, Ill.) (01-09-2007)“…Various accumulating evidence suggests that survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and…”
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3
The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development
Published in Journal of molecular endocrinology (01-10-2018)“…Multiple signaling molecules and transcription factors are required for pituitary development. Activator-type bHLH genes Mash1, Math, NeuroD (Neurod) and…”
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4
Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin
Published in Molecular cancer therapeutics (01-01-2012)“…Loss of PTEN was recently shown to contribute to resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in EGFR…”
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Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development
Published in Brain research (02-11-2015)“…Abstract The pituitary gland is a critical endocrine organ regulating diverse physiological functions, including homeostasis, metabolism, reproduction, and…”
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Interleukin Enhancer-binding Factor 3/NF110 Is a Target of YM155, a Suppressant of Survivin
Published in Molecular & cellular proteomics (01-07-2012)“…Survivin is responsible for cancer progression and drug resistance in many types of cancer. YM155 selectively suppresses the expression of survivin and induces…”
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Hes1 and Hes5 Control the Progenitor Pool, Intermediate Lobe Specification, and Posterior Lobe Formation in the Pituitary Development
Published in Molecular endocrinology (Baltimore, Md.) (01-06-2007)“…The pituitary gland is composed of two distinct entities: the adenohypophysis, including the anterior and intermediate lobes, and the neurohypophysis, known as…”
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Synergistic Antitumor Activities of Sepantronium Bromide (YM155), a Survivin Suppressant, in Combination with Microtubule-Targeting Agents in Triple-Negative Breast Cancer Cells
Published in Biological & pharmaceutical bulletin (01-12-2013)“…Triple-negative breast cancer (TNBC) has a poor prognosis compared to other subtypes, and effective treatment options are limited to cytotoxic agents,…”
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Formulation Design and Evaluation of Liposomal Sepantronium Bromide (YM155), a Small-Molecule Survivin Suppressant, Based on Pharmacokinetic Modeling and Simulation
Published in Pharmaceutical research (01-01-2015)“…Purpose Sepantronium bromide (YM155) is administered by 168-hour continuous infusions in clinical studies due to its time-dependent pharmacological efficacy…”
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Antitumor efficacy and biodistribution of liposomal sepantronium bromide (YM155), a novel small-molecule survivin suppressant
Published in European journal of pharmaceutics and biopharmaceutics (01-09-2014)“…[Display omitted] •Liposomal YM155 greatly improved the level of YM155 circulating in the blood.•Liposomal YM155 showed unexpectedly high accumulation in the…”
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11
Radiosynthesis, biodistribution and imaging of [11 C]YM155, a novel survivin suppressant, in a human prostate tumor-xenograft mouse model
Published in Nuclear medicine and biology (01-02-2013)“…Abstract Introduction Sepantronium bromide (YM155) is an antitumor drug in development and is a first-in-class chemical entity, which is a survivin…”
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12
Application of Spatial Domain Interferometry with the Capon Method to Transcranial Doppler Ultrasonography: a Simulation Study
Published in Advanced Biomedical Engineering (01-01-2015)“…Control of vasospasm is one of the most important problems in postoperative management after the occurrence of subarachnoid hemorrhage. Transcranial Doppler…”
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Sepantronium Bromide (YM155) induces disruption of the ILF3/p54nrb complex, which is required for survivin expression
Published in Biochemical and biophysical research communications (01-09-2012)“…► p54nrb binds to the survivin promoter and regulates survivin expression. ► p54nrb physically interacts with ILF3 through RNA. ► YM155 induces disruption of…”
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Synergistic Antitumor Activities of Sepantronium Bromide (YM155), a Survivin Suppressant, in Combination with Microtubule-Targeting Agents in Triple-Negative Breast Cancer Cells
Published in Biological and Pharmaceutical Bulletin (01-12-2013)“…Triple-negative breast cancer (TNBC) has a poor prognosis compared to other subtypes, and effective treatment options are limited to cytotoxic agents,…”
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15
Antitumor Activity of YM155, a Selective Small-Molecule Survivin Suppressant, Alone and in Combination with Docetaxel in Human Malignant Melanoma Models
Published in Clinical cancer research (15-08-2011)“…Aggressive cell growth and chemoresistance are notorious obstacles in melanoma therapy. Accumulating evidence suggests that survivin is preferentially…”
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Combination of YM155, a Survivin Suppressant, with Bendamustine and Rituximab: A New Combination Therapy to Treat Relapsed/Refractory Diffuse Large B-cell Lymphoma
Published in Clinical cancer research (01-04-2014)“…There remains an unmet therapeutic need for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The purpose of this study was to evaluate…”
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The proneural bHLH genes Mash1, Math3 and NeuroD are required for pituitary development
Published in Journal of molecular endocrinology (01-10-2018)“…Multiple signaling molecules and transcription factors are required for pituitary development. Activator-type bHLH genes Mash1, Math, NeuroD (Neurod) and…”
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Journal Article -
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YM155, a selective survivin suppressant, inhibits tumor spread and prolongs survival in a spontaneous metastatic model of human triple negative breast cancer
Published in International journal of oncology (01-09-2011)“…Metastatic triple negative breast cancer [TNBC, with negative expression of estrogen and progesterone receptors and no overexpression of HER2/neu (ErbB-2)]…”
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Predicting response to sepantronium bromide (YM155), a survivin suppressant, by PET imaging with [11C]YM155
Published in Nuclear medicine and biology (01-09-2018)“…Sepantronium bromide (YM155) is a survivin suppressant that induces apoptosis in tumor cells. Although YM155 induces tumor regression in various tumor types in…”
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Sepantronium bromide (YM155) induces disruption of the ILF3/p54(nrb) complex, which is required for survivin expression
Published in Biochemical and biophysical research communications (07-09-2012)“…YM155, a small-molecule survivin suppressant, specifically binds to the transcription factor ILF3, which regulates the expression of survivin[1]. In this…”
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