Search Results - "Kissinger, Amy L."

Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution by Hagmann, William K, Kissinger, Amy L, Shah, Shrenik K, Finke, Paul E, Dorn, Conrad P, Brause, Karen A, Ashe, Bonnie M, Weston, Hazel, Maycock, Alan L

“…The effect of changing the C-4 substituent of 3,3-diethyl-1-[(benzylamino)carbonyl]-2-azetidinone on inhibition of HLE and in a model of HLE-induced lung…”
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones by Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M

“…A thorough analysis of the mechanism of inhibition of human leukocyte elastase (HLE) by a monocyclic beta-lactam and the mechanism of beta-lactam hydrolysis…”
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Chemical, Biochemical, Pharmacokinetic, and Biological Properties of L-680, 833: A Potent, Orally Active Monocyclic β-Lactam Inhibitor of Human Polymorphonuclear Leukocyte Elastase by Doherty, James B., Shah, Shrenik K., Finke, Paul E., Dorn, Conrad P., Hagmann, William K., Hale, Jeffrey J., Kissinger, Amy L., Thompson, Kevan R., Brause, karen, Chandler, Gilbert O., Knight, Wilson B., Maycock, Alan L., Ashe, Bonnie M., Weston, Hazel, Gale, Paul, Mumford, Richard A., Andersen, O. Frederick, Williams, Hollis R., Nolan, Thomas E., Frankenfield, Dale L., Underwood, Dennis, Vyas, Kamlesh P., Kari, Prasad H., Dahlgren, Mary E., Mao, Jennifer, Fletcher, Daniel S., Pa. S. Dellea, Hand, Karen M., Osinga, Donald G., Peterson, Laurence B., Williams, Dorsey T., Metzger, Joseph M., Bonney, Robert J., Humes, John L., Pacholok, Steven P., Hanlon, William A., Opas, Evan, Stolk, Jan, Davies, Philip

“…A series of potent and highly selective time-dependent monocyclic β-lactam inhibitors of human polymorphonuclear leukocyte elastase (PMNE, EC 3.4.21.37) is…”
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