Search Results - "Kissick, Thomas P."

Enzymatic Desymmetrization of Dimethyl Cylcohex-4-ene-cis-1,2-dicarboxylate to (1S,2R)-2-(Methoxycarbonyl)cyclohex-4-ene-1-carboxylic Acid by Goswami, Animesh, Kissick, Thomas P

“…An efficient process for the synthesis of the monoester, (1S,2R)-2-(methoxycarbonyl)cyclohex-4-ene-1-carboxylic acid by Candida antarctica lipase (Novozym…”
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Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632 by Xu, Zhongmin, Singh, Janak, Schwinden, Mark D, Zheng, Bin, Kissick, Thomas P, Patel, Bharat, Humora, Michael J, Quiroz, Fernando, Dong, Lin, Hsieh, Dau-Ming, Heikes, James E, Pudipeddi, Madhusudhan, Lindrud, Mark D, Srivastava, Sushil K, Kronenthal, David R, Mueller, Richard H

“…Development of an efficient and scalable process for the human immunodeficiency virus (HIV) protease inhibitor BMS-232632…”
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Remarkable β-Selectivity in the Synthesis of β-1-C-Arylglucosides:  Stereoselective Reduction of Acetyl-Protected Methyl 1-C-Arylglucosides without Acetoxy-Group Participation by Deshpande, Prashant P, Ellsworth, Bruce A, Buono, Frederic G, Pullockaran, Annie, Singh, Janak, Kissick, Thomas P, Huang, Ming-H, Lobinger, Hildegard, Denzel, Theodor, Mueller, Richard H

“…An efficient and practical process to generate β-C-arylglucoside derivatives was achieved. The process described involves Lewis acid mediated ionic reduction…”
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A Practical Asymmetric Synthesis of the Antiviral Agent Lobucavir, BMS-180194 by Singh, Janak, Bisacchi, Gregory S, Ahmad, Saleem, Godfrey, Jollie D, Kissick, Thomas P, Mitt, Toomas, Kocy, Octavian, Vu, Truc, Papaioannou, Chris G, Wong, Michael K, Heikes, James E, Zahler, Robert, Mueller, Richard H

“…A practical synthesis of the antiviral agent lobucavir, [1R-(1α,2β,3α)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one (BMS-180194), is described…”
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Conversion of L-pyroglutamic acid to 4-alkyl-substituted L-prolines. The synthesis of trans-4-cyclohexyl-L-proline by Thottathil, John K, Moniot, Jerome L, Mueller, Richard H, Wong, Michael K. Y, Kissick, Thomas P

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Efficient Asymmetric Synthesis of the Vasopeptidase Inhibitor BMS-189921 by Singh, Janak, Kronenthal, David R, Schwinden, Mark, Godfrey, Jollie D, Fox, Rita, Vawter, Edward J, Zhang, Bo, Kissick, Thomas P, Patel, Bharat, Mneimne, Omar, Humora, Michael, Papaioannou, Chris G, Szymanski, Walter, Wong, Michael K. Y, Chen, Chien K, Heikes, James E, DiMarco, John D, Qiu, Jun, Deshpande, Rajendra P, Gougoutas, Jack Z, Mueller, Richard H

“…An efficient asymmetric synthesis of the vasopeptidase inhibitor BMS-189921 was accomplished. Two short enantioselective syntheses of the common key…”
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Regioselective enzymatic aminoacylation of lobucavir to give an intermediate for lobucavir prodrug by Hanson, Ronald L, Shi, Zhongping, Brzozowski, David B, Banerjee, Amit, Kissick, Thomas P, Singh, Janak, Pullockaran, Annie J, North, Jeffrey T, Fan, Junying, Howell, Jeffrey, Durand, Susan C, Montana, Michael A, Kronenthal, David R, Mueller, Richard H, Patel, Ramesh N

“…Synthesis of lobucavir prodrug, L-valine, [(1 S,2 R,3 R)-3-(2-amino-1,6-dihydro-6-oxo-9 H-purin-9-yl)-2-(hydroxymethyl)cyclobutyl]methyl ester…”
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Confirmation of the structure of tetra- O-( tert-butyldimethylsilyl)- d-glucono-1,4-lactone formed by silylation of d-glucono-1,5-lactone by Singh, Janak, DiMarco, John, Kissick, Thomas P, Deshpande, Prashant, Gougoutas, Jack Z

“…The structure of tetra- O-( tert-butyldimethylsilyl)- d-glucono-1,4-lactone made by the silylation of d-glucono-1,5-lactone has been confirmed by…”
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Regioselective Activation of Aminothiazole(iminoxyacetic acid)acetic Acid:  An Efficient Synthesis of the Monobactam Aztreonam by Singh, Janak, Denzel, Theodor W, Fox, Rita, Kissick, Thomas P, Herter, Rolf, Wurdinger, Joseph, Schierling, Peter, Papaioannou, Chris G, Moniot, Jerome L, Mueller, Richard H, Cimarusti, Christopher M

“…An efficient synthesis of the monobactam aztreonam…”
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Cupric bromide mediated oxidation of 4-carboxyoxazolines to the corresponding oxazoles by Barrish, Joel C, Singh, Janak, Spergel, Steven H, Han, Wen Ching, Kissick, Thomas P, Kronenthal, David R, Mueller, Richard H

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Diastereoselective Reaction of a Grignard Reagent with Chiral Imides:  A Practical Preparation of a Key Intermediate in the Synthesis of Ifetroban Sodium by Mueller, Richard H, Wang, Shaopeng, Pansegrau, Paul D, Jannotti, Joy Q, Poss, Michael A, Thottathil, John K, Singh, Janak, Humora, Michael J, Kissick, Thomas P, Boyhan, Brenda

“…A novel and highly efficient synthesis of [1S-(1α,2α,3α,4α)]-2-[[2-(3-methoxy-3-oxopropyl)phenyl]methyl]-7-oxabicyclo[2.2.1]heptane-3-carboxylic acid (A), a…”
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A Practical Asymmetric Synthesis of the Antiviral Agent Lobucavir, BMS-180194 by Singh, Janak, Bisacchi, Gregory S, Ahmad, Saleem, Godfrey, Jollie D, Kissick, Thomas P, Mitt, Toomas, Kocy, Octavian, Vu, Truc, Papaioannou, Chris G, Wong, Michael K, Heikes, James E, Zahler, Robert, Mueller, Richard H

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1-Acyltriazoles as antiinflammatory agents by Wade, Peter C, Vogt, B. Richard, Kissick, Thomas P, Simpkins, Ligaya M, Palmer, Douglas M, Millonig, Robert C

“…Certain 1-acyl-3-phenyl-5-alkyltriazoles were synthesized and evaluated for antiinflammatory activity using the mouse active Arthus (MAA) reaction as the test…”
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The structures of alkoxycarbonyl, acyl, and sulfonate derivatives of 1-hydroxybenzotriazole: nitrogen- vs oxygen-substitution by Singh, Janak, Fox, Rita, Wong, Michael, Kissick, Thomas P, Moniot, Jerome L, Gougoutas, Jack Z, Malley, Mary F, Kocy, Octavian

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Synthesis of the triazolo[5,1-a][2,4]benzodiazepine ring system by Wade, Peter C, Kissick, Thomas P, Vogt, B. Richard, Toeplitz, Barbara

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Regioselective Coupling of Tetraalkylammonium Salts of 6-Iodo-2-aminopurine to a Cyclobutyl Triflate: Efficient Preparation of Homochiral BMS-180,194, a Potent Antiviral Carbocyclic Nucleoside by Bisacchi, Gregory S., Singh, Janak, Godfrey, Jollie D., Kissick, Thomas P., Mitt, Toomas, Malley, Mary F., Di Marco, John D., Gougoutas, Jack Z., Mueller, Richard H., Zahler, Robert

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Synthesis and anti-MRSA Activity of Novel Cephalosporin Derivatives by D'Andrea, Stan V., Bonner, Daniel, Bronson, Joanne J., Clark, Junius, Denbleyker, Ken, Fung-Tomc, Joan, Hoeft, Shelley E., Hudyma, Thomas W., Matiskella, John D., Miller, Raymond F., Misco, Peter F., Pucci, Michael, Sterzycki, Roman, Tsai, Yuan, Ueda, Yasutsuga, Wichtowski, John A., Singh, Janak, Kissick, Thomas P., North, Jeffery T., Pullockaran, Annie, Humora, Michael, Boyhan, Brenda, Vu, Truc, Fritz, Alan, Heikes, J., Fox, Rita, Godfrey, Jollie D., Perrone, Robert, Kaplan, Murray, Kronenthal, David, Mueller, Richard H.

“…Cephalosporin derivatives containing a unique combination of lipophilic C-7 sidechains and polar C-3 thiopyridinium groups were synthesized and found to…”
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A Practical Synthesis of an Anti-Methicillin Resistant Staphylococcus aureus Cephalosporin BMS-247243 by Singh, Janak, Kim, Oak K, Kissick, Thomas P, Natalie, Kenneth J, Zhang, Bo, Crispino, Gerard A, Springer, Dane M, Wichtowski, John A, Zhang, Yunhui, Goodrich, Jason, Ueda, Yasutsugu, Luh, Bing Y, Burke, Brian D, Brown, Matthew, Dutka, Anthony P, Zheng, Bin, Hsieh, Dau-Ming, Humora, Michael J, North, Jeffrey T, Pullockaran, Anne J, Livshits, Juliya, Swaminathan, Shankar, Gao, Zhinong, Schierling, Peter, Ermann, Peter, Perrone, Robert K, Lai, Mei C, Gougoutas, Jack Z, DiMarco, John D, Bronson, Joanne J, Heikes, James E, Grosso, John A, Kronenthal, David R, Denzel, Theodor W, Mueller, Richard H

“…A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem…”
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The structures of alkoxycarbonyl, acyl, and sulfonate derivatives of 1-hydroxybenzotriazole: N- vs O-substitution by JANAK SINGH, FOX, R, WONG, M, KISSICK, T. P, MONIOT, J. L, GOUGOUTAS, J. Z, MALLEY, M. F, KOCY, O

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Synthesis of a novel heterocyclic system: 2-oxo-1,3-dioxolo[4,5-c]pyridine-6-carboxylic acid, phenylmethyl ester by Singh, Janak, Kissick, Thomas P., Mueller, Richard H.

“…The synthesis of heterobicyclic carbonate 4 and its conversions to the mixed carbonate 5 and carbamate 6 are described…”
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