Search Results - "Kisselev, Alexei F"

Site-Specific Proteasome Inhibitors by Kisselev, Alexei F

“…Proteasome is a multi-subunit protein degradation machine, which plays a key role in the maintenance of protein homeostasis and, through degradation of…”
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Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2 by Ibtisam, Ibtisam, Kisselev, Alexei F

“…Rapid recovery of proteasome activity may contribute to intrinsic and acquired resistance to FDA-approved proteasome inhibitors. Previous studies have…”
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NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells by Aliyaskarova, Umit, Baiken, Yeldar, Renaud, Flore, Couve, Sophie, Kisselev, Alexei F., Saparbaev, Murat, Groisman, Regina

“…Anti-neoplastic effect of DNA cross-linking agents such as cisplatin, mitomycin C, and psoralen is attributed to their ability to induce DNA interstrand…”
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A clinically relevant pulse treatment generates a bortezomib-resistant myeloma cell line that lacks proteasome mutations and is sensitive to Bcl-2 inhibitor venetoclax by Downey-Kopyscinski, Sondra L., Srinivasa, Sriraja, Kisselev, Alexei F.

“…Proteasome inhibitors bortezomib and carfilzomib are the backbones of treatments of multiple myeloma, which remains incurable despite many recent advances…”
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Importance of the Different Proteolytic Sites of the Proteasome and the Efficacy of Inhibitors Varies with the Protein Substrate by Kisselev, Alexei F., Callard, Alice, Goldberg, Alfred L.

“…The relative importance of the different proteolytic sites in mammalian proteasomes in protein degradation has not been studied systematically. Nevertheless,…”
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A Novel Bullet Hits the Proteasome by Kisselev, Alexei F.

“…An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the…”
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Certain Pairs of Ubiquitin-conjugating Enzymes (E2s) and Ubiquitin-Protein Ligases (E3s) Synthesize Nondegradable Forked Ubiquitin Chains Containing All Possible Isopeptide Linkages by Kim, Hyoung Tae, Kim, Kwang Pyo, Lledias, Fernando, Kisselev, Alexei F., Scaglione, K. Matthew, Skowyra, Dorota, Gygi, Steven P., Goldberg, Alfred L.

“…It is generally assumed that a specific ubiquitin ligase (E3) links protein substrates to polyubiquitin chains containing a single type of isopeptide linkage,…”
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Activity of immunoproteasome inhibitor ONX-0914 in acute lymphoblastic leukemia expressing MLL–AF4 fusion protein by Jenkins, Tyler W., Downey-Kopyscinski, Sondra L., Fields, Jennifer L., Rahme, Gilbert J., Colley, William C., Israel, Mark A., Maksimenko, Andrey V., Fiering, Steven N., Kisselev, Alexei F.

“…Proteasome inhibitors bortezomib and carfilzomib are approved for the treatment of multiple myeloma and mantle cell lymphoma and have demonstrated clinical…”
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Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA by Albershardt, Tina C., Salerni, Bethany L., Soderquist, Ryan S., Bates, Darcy J.P., Pletnev, Alexandre A., Kisselev, Alexei F., Eastman, Alan

“…BH3 mimetics are small molecules designed or discovered to mimic the binding of BH3-only proteins to the hydrophobic groove of antiapoptotic BCL2 proteins. The…”
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The Ubiquitin Ligase Activity in the DDB2 and CSA Complexes Is Differentially Regulated by the COP9 Signalosome in Response to DNA Damage by Groisman, Regina, Polanowska, Jolanta, Kuraoka, Isao, Sawada, Jun-ichi, Saijo, Masafumi, Drapkin, Ronny, Kisselev, Alexei F., Tanaka, Kiyoji, Nakatani, Yoshihiro

“…Nucleotide excision repair (NER) is a major cellular defense against the carcinogenic effects of ultraviolet light from the sun. Mutational inactivation of NER…”
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CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome by Groisman, Regina, Kuraoka, Isao, Chevallier, Odile, Gaye, Nogaye, Magnaldo, Thierry, Tanaka, Kiyoji, Kisselev, Alexei F, Harel-Bellan, Annick, Nakatani, Yoshihiro

“…Mutations in the CSA or CSB complementation genes cause the Cockayne syndrome, a severe genetic disorder that results in patients' death in early adulthood…”
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Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib by Shabaneh, Tamer B, Downey, Sondra L, Goddard, Ayrton L, Screen, Michael, Lucas, Marcella M, Eastman, Alan, Kisselev, Alexei F

“…The proteasome inhibitor bortezomib (Velcade) is prescribed for the treatment of multiple myeloma. Clinically achievable concentrations of bortezomib cause…”
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The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells by Kraus, Marianne, Bader, Juergen, Geurink, Paul P, Weyburne, Emily S, Mirabella, Anne C, Silzle, Tobias, Shabaneh, Tamer B, van der Linden, Wouter A, de Bruin, Gerjan, Haile, Sarah R, van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F, Overkleeft, Herman, Driessen, Christoph

“…Proteasome inhibitor resistance is a challenge for myeloma therapy. Bortezomib targets the β5 and β1 activity, but not the β2 activity of the proteasome…”
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DNA-Histone Cross-Links: Formation and Repair by Pachva, Manideep C, Kisselev, Alexei F, Matkarimov, Bakhyt T, Saparbaev, Murat, Groisman, Regina

“…The nucleosome is a stretch of DNA wrapped around a histone octamer. Electrostatic interactions and hydrogen bonds between histones and DNA are vital for the…”
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Subunit specific inhibitors of proteasomes and their potential for immunomodulation by Kisselev, Alexei F, Groettrup, Marcus

“…•Structure–function relationship of subunit selective proteasome inhibitors.•Development and characterization of new inhibitors of the…”
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The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites by Kisselev, Alexei F., Garcia-Calvo, Margarita, Overkleeft, Herman S., Peterson, Erin, Pennington, Michael W., Ploegh, Hidde L., Thornberry, Nancy A., Goldberg, Alfred L.

“…Proteasomes are the primary sites for protein degradation in mammalian cells. Each proteasome particle contains two chymotrypsin-like, two trypsin-like, and…”
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Proteasome Active Sites Allosterically Regulate Each Other, Suggesting a Cyclical Bite-Chew Mechanism for Protein Breakdown by Kisselev, Alexei F, Akopian, Tatos N, Castillo, Vanesa, Goldberg, Alfred L

“…In eukaryotes, the 20S proteasome contains two chymotrypsin-like, two trypsin-like, and two active sites shown here to have caspase-like specificity. We report…”
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Proteasome Inhibitors: An Expanding Army Attacking a Unique Target by Kisselev, Alexei F., van der Linden, Wouter A., Overkleeft, Herman S.

“…Proteasomes are large, multisubunit proteolytic complexes presenting multiple targets for therapeutic intervention. The 26S proteasome consists of a 20S…”
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Incorporation of Fluorinated Phenylalanine Generates Highly Specific Inhibitor of Proteasome’s Chymotrypsin-like Sites by Geurink, Paul P, Liu, Nora, Spaans, Michiel P, Downey, Sondra L, van den Nieuwendijk, Adrianus M. C. H, van der Marel, Gijsbert A, Kisselev, Alexei F, Florea, Bogdan I, Overkleeft, Herman S

“…Proteasomal processing is conducted by three individual catalytic subunits, namely β1, β2, and β5. Subunit-specific inhibitors are useful tools in dissecting…”
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The fellowship of the ring by Tevosian, Sergei G., Kisselev, Alexei F.

“…Commentary to: Proteasome inhibitory activity of thiazole antibiotics Bulbul Pandit, Uppoor G. Bhat and Andrei Gartel…”
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