Search Results - "Kiss, Leo"

RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination by Kiss, Leo, Clift, Dean, Renner, Nadine, Neuhaus, David, James, Leo C.

“…Attachment of ubiquitin (Ub) to proteins is one of the most abundant and versatile of all posttranslational modifications and affects outcomes in essentially…”
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A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases by Kiss, Leo, Zeng, Jingwei, Dickson, Claire F., Mallery, Donna L., Yang, Ji-Chun, McLaughlin, Stephen H., Boland, Andreas, Neuhaus, David, James, Leo C.

“…The cytosolic antibody receptor TRIM21 possesses unique ubiquitination activity that drives broad-spectrum anti-pathogen targeting and underpins the protein…”
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Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex by Soni, Komal, Sivadas, Anusree, Horvath, Attila, Dobrev, Nikolay, Hayashi, Rippei, Kiss, Leo, Simon, Bernd, Wild, Klemens, Sinning, Irmgard, Fischer, Tamás

“…The S. pombe orthologue of the human PAXT connection, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex that targets cryptic unstable transcripts (CUTs) to…”
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Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates by Kiss, Leo, Rhinesmith, Tyler, Luptak, Jakub, Dickson, Claire F., Weidenhausen, Jonas, Smyly, Shannon, Yang, Ji-Chun, Maslen, Sarah L., Sinning, Irmgard, Neuhaus, David, Clift, Dean, James, Leo C.

“…TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating…”
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The molecular mechanisms that drive intracellular neutralization by the antibody-receptor and RING E3 ligase TRIM21 by Kiss, Leo, James, Leo C.

“…The cytosolic antibody receptor and RING E3 ligase TRIM21 targets intracellular, antibody-coated immune complexes for degradation and activates the immune…”
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NMR analysis of the backbone dynamics of the small GTP ase Rheb and its interaction with the regulatory protein FKBP 38 by De Cicco, Maristella, Kiss, Leo, Dames, Sonja A.

“…Ras homolog enriched in brain (Rheb) is a small GTP ase that regulates mammalian/mechanistic target of rapamycin complex 1 ( mTORC 1) and, thereby, cell growth…”
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Target-induced clustering activates Trim-Away of pathogens and proteins by Zeng, Jingwei, Santos, Ana Filipa, Mukadam, Aamir S., Osswald, Mariana, Jacques, David A., Dickson, Claire F., McLaughlin, Stephen H., Johnson, Christopher M., Kiss, Leo, Luptak, Jakub, Renner, Nadine, Vaysburd, Marina, McEwan, William A., Morais-de-Sá, Eurico, Clift, Dean, James, Leo C.

“…Trim-Away is a recently developed technology that exploits off-the-shelf antibodies and the RING E3 ligase and cytosolic antibody receptor TRIM21 to carry out…”
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Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice by Salzer, Ralf, Clark, Jordan J., Vaysburd, Marina, Chang, Veronica T., Albecka, Anna, Kiss, Leo, Sharma, Parul, Gonzalez Llamazares, Andres, Kipar, Anja, Hiscox, Julian A., Owen, Andrew, Aricescu, A. Radu, Stewart, James P., James, Leo C., Löwe, Jan

“…The COVID‐19 pandemic, caused by the SARS‐CoV‐2 coronavirus, has triggered a worldwide health emergency. Here, we show that ferritin‐like Dps from…”
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NMR analysis of the backbone dynamics of the small GTPase Rheb and its interaction with the regulatory protein FKBP38 by De Cicco, Maristella, Kiss, Leo, Dames, Sonja A.

“…Ras homolog enriched in brain (Rheb) is a small GTPase that regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) and, thereby, cell growth…”
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A stable immature lattice packages IP6 for HIV capsid maturation by Mallery, Donna L, Kleinpeter, Alex B, Renner, Nadine, Faysal, K M Rifat, Novikova, Mariia, Kiss, Leo, Wilson, Miranda S C, Ahsan, Bilal, Ke, Zunlong, Briggs, John A G, Saiardi, Adolfo, Böcking, Till, Freed, Eric O, James, Leo C

“…HIV virion assembly begins with the construction of an immature lattice consisting of Gag hexamers. Upon virion release, protease-mediated Gag cleavage leads…”
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A stable immature lattice packages IP 6 for HIV capsid maturation by Mallery, Donna L, Kleinpeter, Alex B, Renner, Nadine, Faysal, K M Rifat, Novikova, Mariia, Kiss, Leo, Wilson, Miranda S C, Ahsan, Bilal, Ke, Zunlong, Briggs, John A G, Saiardi, Adolfo, Böcking, Till, Freed, Eric O, James, Leo C

“…HIV virion assembly begins with the construction of an immature lattice consisting of Gag hexamers. Upon virion release, protease-mediated Gag cleavage leads…”
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The Impact of the COVID-19 Pandemic on Colorectal Cancer Patients in a Tertiary Center in Romania. Single Center Retrospective Study by Kiss, Botond István, Sala, Tatiana Daniela, Török, Árpád, Dénes, Márton István, Borz, Cristian Oliviu, Popescu, Gabriel Alexandru, Jr, Tivadar Bara, Muresan, Mircea Gabriel, Darie, Ruxandra, Daniealopol, Valentin, Scurtu, Georgiana Alexandra, Székely, Tamás, Gábor-Kelemen, Andrea, Fülöp, Zsolt, Sárdi, Kálmán Gabriel, Kiss, Szilárd Leó, Neagoe, Radu Mircea

“…The novel coronavirus, SARS-COV-2, was first reported in Wuhan, China in the end of 2019. To curb its spread, social distancing measures and new safety…”
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Total Infralevatorian Exenteration with Vulvectomy as Salvage Therapy in a Recurrent Irradiated Cervical Cancer with Pelvic Sidewall Involvement by Bécsi, János, Szabó, Béla, Kiss, Szilárd Leó, Căpîlna, Mihai Emil

“…Despite the available effective screening techniques, cervical cancer is the most common genital malignancy in Romania. In patients with isolated pelvic…”
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Primary pelvic exenteration: Our experience with 23 patients from a single institution by Gheorghe, Mihai, Cozlea, Alexandra Lavinia, Kiss, Szilard Leo, Stanca, Mihai, Capilna, Mihai Emil, Bacalbasa, Nicolae, Moldovan, Andreea Anamaria

“…This study was designed with an aim to share our experience of primary pelvic exenterations. The study included 23 patients with different types of pelvic…”
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The Double Life-Saving Approach of Abdominal Radical Trachelectomy during Pregnancy for Early-Stage Cervical Cancer-An Overview of the Literature and Our Institutional Experience by Stanca, Mihai, Ciobanu, Victoria, Gheorghe, Mihai, Kiss, Szilard Leo, Cozlea, Alexandra Lavinia, Căpîlna, Mihai Emil

“…(1) Background: Cervical cancer is the most common type of cancer encountered during pregnancy, with a frequency of 0.8-1.5 cases per 10,000 births. It is a…”
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Malignant mixed Müllerian tumor of the fallopian tube: Case report and literature review by Cozlea, Alexandra Lavinia, Gheorghe, Mihai, Kiss, Szilard Leo, Fandi, Anas, Stanca, Mihai, Mocan, Simona, Capilna, Mihai Emil, Bacalbasa, Nicolae, Moldovan, Andreea Anamaria

“…Carcinosarcoma, also known as malignant mixed Mullerian tumor (MMMT), includes both malignant epithelial and mesenchymal elements. While the endometrium is the…”
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Abdominal radical trachelectomy as fertility-sparing management for early stages of cervical cancer: Our experience in 18 cases by Kiss, Szilard Leo, Fandi, Anas, Cozlea, Alexandra Lavinia, Gheorghe, Mihai, Stanca, Mihai, Bacalbașa, Nicolae, Moldovan, Andreea Anamaria, Căpîlna, Mihai Emil

“…The aim of this study was to present our experience of 18 cases of abdominal radical trachelectomy (ART), including 5 performed during pregnancy, analyzing…”
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