Search Results - "Kiso, Shinichi"

Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet by Kamada, Yoshihiro, Kiso, Shinichi, Yoshida, Yuichi, Chatani, Norihiro, Kizu, Takashi, Hamano, Mina, Tsubakio, Mayumi, Takemura, Takayo, Ezaki, Hisao, Hayashi, Norio, Takehara, Tetsuo

“…Recent studies indicate an accelerated progression of nonalcoholic steatohepatitis (NASH) in postmenopausal women. Hypercholesterolemia, an important risk…”
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Lipid overloading during liver regeneration causes delayed hepatocyte DNA replication by increasing ER stress in mice with simple hepatic steatosis by Hamano, Mina, Ezaki, Hisao, Kiso, Shinichi, Furuta, Kunimaro, Egawa, Mayumi, Kizu, Takashi, Chatani, Norihiro, Kamada, Yoshihiro, Yoshida, Yuichi, Takehara, Tetsuo

“…Background and aim Impaired fatty liver regeneration has already been reported in many genetic modification models. However, in diet-induced simple hepatic…”
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Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen‐induced liver injury in mice by Furuta, Kunimaro, Yoshida, Yuichi, Ogura, Satoshi, Kurahashi, Tomohide, Kizu, Takashi, Maeda, Shinichiro, Egawa, Mayumi, Chatani, Norihiro, Nishida, Keigo, Nakaoka, Yoshikazu, Kiso, Shinichi, Kamada, Yoshihiro, Takehara, Tetsuo

“…Acetaminophen (APAP) overdose is the leading cause of drug‐induced acute liver failure. In APAP‐induced acute liver failure, hepatocyte death and subsequent…”
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Secreted frizzled-related protein 5 (Sfrp5) decreases hepatic stellate cell activation and liver fibrosis by Chatani, Norihiro, Kamada, Yoshihiro, Kizu, Takashi, Ogura, Satoshi, Furuta, Kunimaro, Egawa, Mayumi, Hamano, Mina, Ezaki, Hisao, Kiso, Shinichi, Shimono, Akihiko, Ouchi, Noriyuki, Yoshida, Yuichi, Takehara, Tetsuo

“…Background & Aims Obesity‐related adipocytokine dysregulation is known to accelerate liver fibrosis progression. Recently, a natural Wnt5a inhibitor, secreted…”
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Serum Fucosylated Haptoglobin as a Novel Diagnostic Biomarker for Predicting Hepatocyte Ballooning and Nonalcoholic Steatohepatitis by Kamada, Yoshihiro, Akita, Maaya, Takeda, Yuri, Yamada, Shin, Fujii, Hideki, Sawai, Yoshiyuki, Doi, Yoshinori, Asazawa, Hitomi, Nakayama, Kotarosumitomo, Mizutani, Kayo, Fujii, Hironobu, Yakushijin, Takayuki, Miyazaki, Masanori, Ezaki, Hisao, Hiramatsu, Naoki, Yoshida, Yuichi, Kiso, Shinichi, Imai, Yasuharu, Kawada, Norifumi, Takehara, Tetsuo, Miyoshi, Eiji

“…Nonalcoholic fatty liver disease (NAFLD) is a growing medical problem around the world. NAFLD patients with nonalcoholic steatohepatitis (NASH) can develop…”
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Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization by Fukushima, Juichi, Kamada, Yoshihiro, Matsumoto, Hitoshi, Yoshida, Yuichi, Ezaki, Hisao, Takemura, Takayo, Saji, Yukiko, Igura, Takumi, Tsutsui, Shusaku, Kihara, Shinji, Funahashi, Tohru, Shimomura, Iichiro, Tamura, Shinji, Kiso, Shinichi, Hayashi, Norio

“…Aim:  We reported previously that hypoadiponectinemia enhances hepatic oxidative stress and accelerates progression of nonalcoholic steatohepatitis (NASH) in…”
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Targeting the mevalonate pathway is a novel therapeutic approach to inhibit oncogenic FoxM1 transcription factor in human hepatocellular carcinoma by Ogura, Satoshi, Yoshida, Yuichi, Kurahashi, Tomohide, Egawa, Mayumi, Furuta, Kunimaro, Kiso, Shinichi, Kamada, Yoshihiro, Hikita, Hayato, Eguchi, Hidetoshi, Ogita, Hisakazu, Doki, Yuichiro, Mori, Masaki, Tatsumi, Tomohide, Takehara, Tetsuo

“…Dysregulation of cell metabolism is a hallmark of cancer. The mevalonate pathway in lipid metabolism has been implicated as a potential target of cancer…”
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Long-term effect of lamivudine treatment on the incidence of hepatocellular carcinoma in patients with hepatitis B virus infection by Kurokawa, Mika, Hiramatsu, Naoki, Oze, Tsugiko, Yakushijin, Takayuki, Miyazaki, Masanori, Hosui, Atsushi, Miyagi, Takuya, Yoshida, Yuichi, Ishida, Hisashi, Tatsumi, Tomohide, Kiso, Shinichi, Kanto, Tatsuya, Kasahara, Akinori, Iio, Sadaharu, Doi, Yoshinori, Yamada, Akira, Oshita, Masahide, Kaneko, Akira, Mochizuki, Kiyoshi, Hagiwara, Hideki, Mita, Eiji, Ito, Toshifumi, Inui, Yoshiaki, Katayama, Kazuhiro, Yoshihara, Harumasa, Imai, Yasuharu, Hayashi, Eijirou, Hayashi, Norio, Takehara, Tetsuo

“…Background Nucleotide analogues have recently been approved for the treatment of patients with hepatitis B virus (HBV) infection. However, it is still…”
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Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin by Kamada, Yoshihiro, Tamura, Shinji, Kiso, Shinichi, Matsumoto, Hitoshi, Saji, Yukiko, Yoshida, Yuichi, Fukui, Koji, Maeda, Norikazu, Nishizawa, Hitoshi, Nagaretani, Hiroyuki, Okamoto, Yoshihisa, Kihara, Shinji, Miyagawa, Jun-ichiro, Shinomura, Yasuhisa, Funahashi, Tohru, Matsuzawa, Yuji

“…Background & Aims : Obesity is one of the risk factors for liver fibrosis, in which plasma adiponectin, an adipocytokine, levels are decreased. Hepatic…”
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Conditional loss of heparin-binding EGF-like growth factor results in enhanced liver fibrosis after bile duct ligation in mice by Takemura, Takayo, Yoshida, Yuichi, Kiso, Shinichi, Kizu, Takashi, Furuta, Kunimaro, Ezaki, Hisao, Hamano, Mina, Egawa, Mayumi, Chatani, Norihiro, Kamada, Yoshihiro, Imai, Yasuharu, Higashiyama, Shigeki, Iwamoto, Ryo, Mekada, Eisuke, Takehara, Tetsuo

“…•HB-EGF expression was increased during the development of liver fibrosis.•Conditional HB-EGF knockout mouse showed enhanced experimental liver…”
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Increased expression of Forkhead box M1 transcription factor is associated with clinicopathological features and confers a poor prognosis in human hepatocellular carcinoma by Egawa, Mayumi, Yoshida, Yuichi, Ogura, Satoshi, Kurahashi, Tomohide, Kizu, Takashi, Furuta, Kunimaro, Kamada, Yoshihiro, Chatani, Norihiro, Hamano, Mina, Kiso, Shinichi, Hikita, Hayato, Tatsumi, Tomohide, Eguchi, Hidetoshi, Nagano, Hiroaki, Doki, Yuichiro, Mori, Masaki, Takehara, Tetsuo

“…Aim Forkhead Box M1 (FoxM1) is a proliferation‐specific transcription factor. In this study, we aimed to elucidate the clinicopathological and prognostic…”
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Expression of Rab5a in hepatocellular carcinoma: Possible involvement in epidermal growth factor signaling by Fukui, Koji, Tamura, Shinji, Wada, Akira, Kamada, Yoshihiro, Igura, Takumi, Kiso, Shinichi, Hayashi, Norio

“…Aim:  The Rab subfamily plays a role in intracellular transport. Rab5a is, in particular, involved in receptor‐mediated endocytosis. Epidermal growth factor…”
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Association of low serum adiponectin levels with erosive esophagitis in men: an analysis of 2405 subjects undergoing physical check-ups by Kato, Motohiko, Watabe, Kenji, Hamasaki, Toshimitsu, Umeda, Miyuki, Furubayashi, Aiko, Kinoshita, Kazuo, Kishida, Osamu, Fujimoto, Takashi, Yamada, Akira, Tsukamoto, Yoshifumi, Yamamoto, Shunsuke, Kamada, Yoshihiro, Yoshida, Yuichi, Kiso, Shinichi, Tsutsui, Shusaku, Kihara, Shinji, Hayashi, Norio, Matsuzawa, Yuji

“…Background Obesity is a risk factor for gastro-esophageal reflux disease (GERD). It is generally considered that intra-abdominal pressure in obese subjects is…”
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novel therapeutic strategy with anti-CD9 antibody in gastric cancers by Nakamoto, Taisei, Murayama, Yoko, Oritani, Kenji, Boucheix, Claude, Rubinstein, Eric, Nishida, Makoto, Katsube, Fumie, Watabe, Kenji, Kiso, Shinichi, Tsutsui, Shusaku, Tamura, Shinji, Shinomura, Yasuhisa, Hayashi, Norio

“…Background CD9 is a member of the tetraspanins, and has been shown to be involved in a variety of cellular activities such as motility, cell signaling,…”
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Loss of Gab1 adaptor protein in hepatocytes aggravates experimental liver fibrosis in mice by Kizu, Takashi, Yoshida, Yuichi, Furuta, Kunimaro, Ogura, Satoshi, Egawa, Mayumi, Chatani, Norihiro, Hamano, Mina, Takemura, Takayo, Ezaki, Hisao, Kamada, Yoshihiro, Nishida, Keigo, Nakaoka, Yoshikazu, Kiso, Shinichi, Takehara, Tetsuo

“…Grb2-associated binder 1 (Gab1) adaptor protein amplifies signals downstream of a broad range of growth factors/receptor tyrosine kinases. Although these…”
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Conditional knockout of heparin-binding epidermal growth factor-like growth factor in the liver accelerates carbon tetrachloride-induced liver injury in mice by Takemura, Takayo, Yoshida, Yuichi, Kiso, Shinichi, Saji, Yukiko, Ezaki, Hisao, Hamano, Mina, Kizu, Takashi, Egawa, Mayumi, Chatani, Norihiro, Furuta, Kunimaro, Kamada, Yoshihiro, Iwamoto, Ryo, Mekada, Eisuke, Higashiyama, Shigeki, Hayashi, Norio, Takehara, Tetsuo

“…Aim:  We previously demonstrated that heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is induced in response to several liver injuries…”
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Adiponectin deficiency exacerbates lipopolysaccharide/ D-galactosamine-induced liver injury in mice by Matsumoto, Hitoshi, Tamura, Shinji, Kamada, Yoshihiro, Kiso, Shinichi, Fukushima, Juichi, Wada, Akira, Maeda, Norikazu, Kihara, Shinji, Funahashi, Tohru, Matsuzawa, Yuji, Shimomura, Iichiro, Hayashi, Norio

“…AIM： To examine the effects of adiponectin on the functions of Kupffer cells, key modulators of lipopolysaccharide （LPS） -induced liver injury.METHODS：…”
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Adiponectin deficiency enhanced the severity of cerulein-induced chronic pancreatitis in mice by Yamada, Takuya, Araki, Hiroshi, Watabe, Kenji, Kamada, Yoshihiro, Kiso, Shinichi, Ogiyama, Hideharu, Nishihara, Tamao, Kihara, Shinji, Funahashi, Tohru, Shimomura, Iichiro, Tsutsui, Shusaku, Hayashi, Norio

“…Background Adiponectin is recognized as an antiinflammatory and antifibrotic protein derived from adipocytes, and low serum adiponectin levels are present in…”
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Pitavastatin ameliorated the progression of steatohepatitis in ovariectomized mice fed a high fat and high cholesterol diet by Kamada, Yoshihiro, Kiso, Shinichi, Yoshida, Yuichi, Chatani, Norihiro, Kizu, Takashi, Hamano, Mina, Egawa, Mayumi, Takemura, Takayo, Ezaki, Hisao, Furuta, Kunimaro, Hayashi, Norio, Takehara, Tetsuo

“…Aim Many studies indicate an accelerated progression of non‐alcoholic steatohepatitis (NASH) in postmenopausal women. Very recently, we reported that estrogen…”
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Transplantation of basic fibroblast growth factor-pretreated adipose tissue-derived stromal cells enhances regression of liver fibrosis in mice by Kamada, Yoshihiro, Yoshida, Yuichi, Saji, Yukiko, Fukushima, Juichi, Tamura, Shinji, Kiso, Shinichi, Hayashi, Norio

“…Adipose tissue-derived stromal cells (ADSC) potentially differentiate into various cell types similar to bone marrow-derived mesenchymal stromal cells (BMSC)…”
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