Search Results - "Kishton, Rigel J"

Identification of essential genes for cancer immunotherapy by Patel, Shashank J., Sanjana, Neville E., Kishton, Rigel J., Eidizadeh, Arash, Vodnala, Suman K., Cam, Maggie, Gartner, Jared J., Jia, Li, Steinberg, Seth M., Yamamoto, Tori N., Merchant, Anand S., Mehta, Gautam U., Chichura, Anna, Shalem, Ophir, Tran, Eric, Eil, Robert, Sukumar, Madhusudhanan, Guijarro, Eva Perez, Day, Chi-Ping, Robbins, Paul, Feldman, Steve, Merlino, Glenn, Zhang, Feng, Restifo, Nicholas P.

“…Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunotherapies. Here we perturbed genes in human melanoma cells to mimic…”
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Metabolic reprograming of anti-tumor immunity by Sukumar, Madhusudhanan, Kishton, Rigel J, Restifo, Nicholas P

“…Highlights • Memory T cells have quiescent metabolism. • Activation of T cells triggers both glycolysis and oxidative phosphorylation. • Elevated T cell…”
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction by Collins, Nicholas, Han, Seong-Ji, Enamorado, Michel, Link, Verena M., Huang, Bonnie, Moseman, E. Ashley, Kishton, Rigel J., Shannon, John P., Dixit, Dhaval, Schwab, Susan R., Hickman, Heather D., Restifo, Nicholas P., McGavern, Dorian B., Schwartzberg, Pamela L., Belkaid, Yasmine

“…Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we…”
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Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism by Johnson, Marc O., Wolf, Melissa M., Madden, Matthew Z., Andrejeva, Gabriela, Sugiura, Ayaka, Contreras, Diana C., Maseda, Damian, Liberti, Maria V., Paz, Katelyn, Kishton, Rigel J., Johnson, Matthew E., de Cubas, Aguirre A., Wu, Pingsheng, Li, Gongbo, Zhang, Yongliang, Newcomb, Dawn C., Wells, Andrew D., Restifo, Nicholas P., Rathmell, W. Kimryn, Locasale, Jason W., Davila, Marco L., Blazar, Bruce R., Rathmell, Jeffrey C.

“…Activated T cells differentiate into functional subsets with distinct metabolic programs. Glutaminase (GLS) converts glutamine to glutamate to support the…”
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Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas by Dersh, Devin, Phelan, James D., Gumina, Megan E., Wang, Boya, Arbuckle, Jesse H., Holly, Jaroslav, Kishton, Rigel J., Markowitz, Tovah E., Seedhom, Mina O., Fridlyand, Nathan, Wright, George W., Huang, Da Wei, Ceribelli, Michele, Thomas, Craig J., Lack, Justin B., Restifo, Nicholas P., Kristie, Thomas M., Staudt, Louis M., Yewdell, Jonathan W.

“…Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is…”
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AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival by Kishton, Rigel J., Barnes, Carson E., Nichols, Amanda G., Cohen, Sivan, Gerriets, Valerie A., Siska, Peter J., Macintyre, Andrew N., Goraksha-Hicks, Pankuri, de Cubas, Aguirre A., Liu, Tingyu, Warmoes, Marc O., Abel, E. Dale, Yeoh, Allen Eng Juh, Gershon, Timothy R., Rathmell, W. Kimryn, Richards, Kristy L., Locasale, Jason W., Rathmell, Jeffrey C.

“…T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy associated with Notch pathway mutations. While both normal activated and leukemic…”
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Arginine Arms T Cells to Thrive and Survive by Kishton, Rigel J., Sukumar, Madhusudhanan, Restifo, Nicholas P.

“…A clear role for cellular metabolism in regulating immune cell function has recently been established. In a recent issue of Cell, Geiger et al. (2016)…”
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Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy by Kishton, Rigel J., Sukumar, Madhusudhanan, Restifo, Nicholas P.

“…Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers. T cells…”
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CDK4/6 Therapeutic Intervention and Viable Alternative to Taxanes in CRPC by Stice, James P, Wardell, Suzanne E, Norris, John D, Yllanes, Alexander P, Alley, Holly M, Haney, Victoria O, White, Hannah S, Safi, Rachid, Winter, Peter S, Cocce, Kimberly J, Kishton, Rigel J, Lawrence, Scott A, Strum, Jay C, McDonnell, Donald P

“…Resistance to second-generation androgen receptor (AR) antagonists and CYP17 inhibitors in patients with castration-resistant prostate cancer (CRPC) develops…”
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Developing neoantigen-targeted T cell–based treatments for solid tumors by Yamamoto, Tori N., Kishton, Rigel J., Restifo, Nicholas P.

“…Stimulating an immune response against cancer through adoptive transfer of tumor-targeting lymphocytes has shown great promise in hematological malignancies,…”
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A guide to immunometabolism for immunologists by O'Neill, Luke A. J., Kishton, Rigel J., Rathmell, Jeff

“…Key Points Immunometabolism describes the changes that occur in intracellular metabolic pathways in immune cells during activation. Six major pathways have…”
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T cell stemness and dysfunction in tumors are triggered by a common mechanism by Vodnala, Suman Kumar, Eil, Robert, Kishton, Rigel J, Sukumar, Madhusudhanan, Yamamoto, Tori N, Ha, Ngoc-Han, Lee, Ping-Hsien, Shin, MinHwa, Patel, Shashank J, Yu, Zhiya, Palmer, Douglas C, Kruhlak, Michael J, Liu, Xiaojing, Locasale, Jason W, Huang, Jing, Roychoudhuri, Rahul, Finkel, Toren, Klebanoff, Christopher A, Restifo, Nicholas P

“…A paradox of tumor immunology is that tumor-infiltrating lymphocytes are dysfunctional in situ, yet are capable of stem cell-like behavior including…”
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Foxp3 and Toll-like receptor signaling balance T reg cell anabolic metabolism for suppression by Gerriets, Valerie A, Kishton, Rigel J, Johnson, Marc O, Cohen, Sivan, Siska, Peter J, Nichols, Amanda G, Warmoes, Marc O, de Cubas, Aguirre A, MacIver, Nancie J, Locasale, Jason W, Turka, Laurence A, Wells, Andrew D, Rathmell, Jeffrey C

“…CD4 effector T cells (T cells) and regulatory T cells (T cells) undergo metabolic reprogramming to support proliferation and immunological function. Although…”
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mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation by Zeng, Hu, Cohen, Sivan, Guy, Cliff, Shrestha, Sharad, Neale, Geoffrey, Brown, Scott A., Cloer, Caryn, Kishton, Rigel J., Gao, Xia, Youngblood, Ben, Do, Mytrang, Li, Ming O., Locasale, Jason W., Rathmell, Jeffrey C., Chi, Hongbo

“…Follicular helper T (Tfh) cells are crucial for germinal center (GC) formation and humoral adaptive immunity. Mechanisms underlying Tfh cell differentiation in…”
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Next generation immunotherapy: enhancing stemness of polyclonal T cells to improve anti-tumor activity by Kishton, Rigel J, Vodnala, Suman K, Vizcardo, Raul, Restifo, Nicholas P

“…•Administration of expanded tumor infiltrating lymphocytes (TILs) can mediate high response rates in cancer patients.•Clinical correlates of response include…”
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Strength in Numbers: Identifying Neoantigen Targets for Cancer Immunotherapy by Kishton, Rigel J., Lynn, Rachel C., Restifo, Nicholas P.

“…Targeting cancer neoantigens generated by tumor-exclusive somatic mutations is an attractive yet challenging strategy for the robust and specific elimination…”
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Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation by Gerriets, Valerie A, Kishton, Rigel J, Nichols, Amanda G, Macintyre, Andrew N, Inoue, Makoto, Ilkayeva, Olga, Winter, Peter S, Liu, Xiaojing, Priyadharshini, Bhavana, Slawinska, Marta E, Haeberli, Lea, Huck, Catherine, Turka, Laurence A, Wood, Kris C, Hale, Laura P, Smith, Paul A, Schneider, Martin A, MacIver, Nancie J, Locasale, Jason W, Newgard, Christopher B, Shinohara, Mari L, Rathmell, Jeffrey C

“…Activation of CD4+ T cells results in rapid proliferation and differentiation into effector and regulatory subsets. CD4+ effector T cell (Teff) (Th1 and Th17)…”
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Fine-tuning T cell function through engineered orthogonal chimeric cytokine receptors by Kishton, Rigel J., Restifo, Nicholas P.

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T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy by Yamamoto, Tori N, Lee, Ping-Hsien, Vodnala, Suman K, Gurusamy, Devikala, Kishton, Rigel J, Yu, Zhiya, Eidizadeh, Arash, Eil, Robert, Fioravanti, Jessica, Gattinoni, Luca, Kochenderfer, James N, Fry, Terry J, Aksoy, Bulent Arman, Hammerbacher, Jeffrey E, Cruz, Anthony C, Siegel, Richard M, Restifo, Nicholas P, Klebanoff, Christopher A

“…Across clinical trials, T cell expansion and persistence following adoptive cell transfer (ACT) have correlated with superior patient outcomes. Herein, we…”
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Leptin directly promotes T‐cell glycolytic metabolism to drive effector T‐cell differentiation in a mouse model of autoimmunity by Gerriets, Valerie A., Danzaki, Keiko, Kishton, Rigel J., Eisner, William, Nichols, Amanda G., Saucillo, Donte C., Shinohara, Mari L., MacIver, Nancie J.

“…Upon activation, T cells require energy for growth, proliferation, and function. Effector T (Teff) cells, such as Th1 and Th17 cells, utilize high levels of…”
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