Search Results - "Kishi, Chieko"

Targeting of early endosomes by autophagy facilitates EGFR recycling and signalling by Fraser, Jane, Simpson, Joanne, Fontana, Rosa, Kishi‐Itakura, Chieko, Ktistakis, Nicholas T, Gammoh, Noor

“…Despite recently uncovered connections between autophagy and the endocytic pathway, the role of autophagy in regulating endosomal function remains incompletely…”
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Autophagy-deficient mice develop multiple liver tumors by Takamura, Akito, Komatsu, Masaaki, Hara, Taichi, Sakamoto, Ayako, Kishi, Chieko, Waguri, Satoshi, Eishi, Yoshinobu, Hino, Okio, Tanaka, Keiji, Mizushima, Noboru

“…Autophagy is a major pathway for degradation of cytoplasmic proteins and organelles, and has been implicated in tumor suppression. Here, we report that mice…”
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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells by Hara, Taichi, Takamura, Akito, Kishi, Chieko, Iemura, Shun-ichiro, Natsume, Tohru, Guan, Jun-Lin, Mizushima, Noboru

“…Autophagy is a membrane-mediated intracellular degradation system. The serine/threonine kinase Atg1 plays an essential role in autophagosome formation…”
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Ultrastructural insights into pathogen clearance by autophagy by Kishi‐Itakura, Chieko, Ktistakis, Nicholas T., Buss, Folma

“…Autophagy defends cells against proliferation of bacteria such as Salmonella in the cytosol. After escape from a damaged Salmonella‐containing vacuole (SCV)…”
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Autophagy Is Essential for Preimplantation Development of Mouse Embryos by Tsukamoto, Satoshi, Kuma, Akiko, Murakami, Mirei, Kishi, Chieko, Yamamoto, Akitsugu, Mizushima, Noboru

“…After fertilization, maternal proteins in oocytes are degraded and new proteins encoded by the zygotic genome are synthesized. We found that autophagy, a…”
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A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells by Mizushima, Noboru, Kc, Wumesh, Lennerz, Jochen K, Cadwell, Ken, Li, Ellen, Brown, Sarah L, Liu, John Y, Kishi, Chieko, Stone, Christian D, Xavier, Ramnik J, Sleckman, Barry P, Hunt, Steven, Virgin IV, Herbert W, Loh, Joy, Miyoshi, Hiroyuki, Stappenbeck, Thaddeus S, Brunt, Elizabeth M, Carrero, Javier A

“…Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele…”
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Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells by Kishi-Itakura, Chieko, Koyama-Honda, Ikuko, Itakura, Eisuke, Mizushima, Noboru

“…Autophagy is mediated by a unique organelle, the autophagosome. Autophagosome formation involves a number of autophagy-related (ATG) proteins and complicated…”
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Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy by Itakura, Eisuke, Kishi-Itakura, Chieko, Koyama-Honda, Ikuko, Mizushima, Noboru

“…Mitochondria can be degraded by autophagy in a process termed mitophagy. The Parkinson-disease-associated ubiquitin ligase Parkin can trigger mitophagy of…”
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Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform by Zachari, Maria, Gudmundsson, Sigurdur R., Li, Ziyue, Manifava, Maria, Cugliandolo, Fiorella, Shah, Ronak, Smith, Matthew, Stronge, James, Karanasios, Eleftherios, Piunti, Caterina, Kishi-Itakura, Chieko, Vihinen, Helena, Jokitalo, Eija, Guan, Jun-Lin, Buss, Folma, Smith, Andrew M., Walker, Simon A., Eskelinen, Eeva-Liisa, Ktistakis, Nicholas T.

“…The dynamics and coordination between autophagy machinery and selective receptors during mitophagy are unknown. Also unknown is whether mitophagy depends on…”
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Loss of functional MYO1C/myosin 1c, a motor protein involved in lipid raft trafficking, disrupts autophagosome-lysosome fusion by Brandstaetter, Hemma, Kishi-Itakura, Chieko, Tumbarello, David A, Manstein, Dietmar J, Buss, Folma

“…MYO1C, a single-headed class I myosin, associates with cholesterol-enriched lipid rafts and facilitates their recycling from intracellular compartments to the…”
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Autophagy-related Atg8 localizes to the apicoplast of the human malaria parasite Plasmodium falciparum by Kitamura, Kei, Kishi-Itakura, Chieko, Tsuboi, Takafumi, Sato, Shigeharu, Kita, Kiyoshi, Ohta, Nobuo, Mizushima, Noboru

“…Autophagy is a membrane-mediated degradation process, which is governed by sequential functions of Atg proteins. Although Atg proteins are highly conserved in…”
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Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells by Kishi-Itakura, Chieko, Koyama-Honda, Ikuko, Itakura, Eisuke, Mizushima, Noboru

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Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG by Itakura, Eisuke, Kishi, Chieko, Inoue, Kinji, Mizushima, Noboru

“…Class III phosphatidylinositol 3-kinase (PI3-kinase) regulates multiple membrane trafficking. In yeast, two distinct PI3-kinase complexes are known: complex I…”
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Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy by Hosokawa, Nao, Hara, Taichi, Kaizuka, Takeshi, Kishi, Chieko, Takamura, Akito, Miura, Yutaka, Iemura, Shun-ichiro, Natsume, Tohru, Takehana, Kenji, Yamada, Naoyuki, Guan, Jun-Lin, Oshiro, Noriko, Mizushima, Noboru

“…Autophagy is an intracellular degradation system, by which cytoplasmic contents are degraded in lysosomes. Autophagy is dynamically induced by nutrient…”
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Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane by Yoshii, Saori R., Kishi, Chieko, Ishihara, Naotada, Mizushima, Noboru

“…Upon mitochondrial depolarization, Parkin, a Parkinson disease-related E3 ubiquitin ligase, translocates from the cytosol to mitochondria and promotes their…”
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The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes by Itakura, Eisuke, Kishi-Itakura, Chieko, Mizushima, Noboru

“…The lysosome is a degradative organelle, and its fusion with other organelles is strictly regulated. In contrast to fusion with the late endosome, the…”
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The Use of Correlative Light-Electron Microscopy (CLEM) to Study PINK1/Parkin-Mediated Mitophagy by Kishi-Itakura, Chieko, Buss, Folma

“…In this chapter we describe the use of correlative light-electron microscopy (CLEM) to study, in cultured cells, the turnover of damaged mitochondria by…”
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Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria by Kruppa, Antonina J., Kishi-Itakura, Chieko, Masters, Thomas A., Rorbach, Joanna E., Grice, Guinevere L., Kendrick-Jones, John, Nathan, James A., Minczuk, Michal, Buss, Folma

“…Mitochondrial quality control is essential to maintain cellular homeostasis and is achieved by removing damaged, ubiquitinated mitochondria via Parkin-mediated…”
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Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform by Zachari, Maria, Gudmundsson, Sigurdur R, Li, Ziyue, Manifava, Maria, Cugliandolo, Fiorella, Shah, Ronak, Smith, Matthew, Stronge, James, Karanasios, Eleftherios, Piunti, Caterina, Kishi-Itakura, Chieko, Vihinen, Helena, Jokitalo, Eija, Guan, Jun-Lin, Buss, Folma, Smith, Andrew M, Walker, Simon A, Eskelinen, Eeva-Liisa, Ktistakis, Nicholas T

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GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis by Goodwin, Jonathan M, Walkup, 4th, Ward G, Hooper, Kirsty, Li, Taoyingnan, Kishi-Itakura, Chieko, Ng, Aylwin, Lehmberg, Timothy, Jha, Archana, Kommineni, Sravya, Fletcher, Katherine, Garcia-Fortanet, Jorge, Fan, Yaya, Tang, Qing, Wei, Menghao, Agrawal, Asmita, Budhe, Sagar R, Rouduri, Sreekanth R, Baird, Dan, Saunders, Jeff, Kiselar, Janna, Chance, Mark R, Ballabio, Andrea, Appleton, Brent A, Brumell, John H, Florey, Oliver, Murphy, Leon O

“…Adaptive changes in lysosomal capacity are driven by the transcription factors TFEB and TFE3 in response to increased autophagic flux and endolysosomal stress,…”
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