Search Results - "Kiselyov, Alexander S"

Novel inhibitors of VEGF receptors-1 and -2 based on azole-5-carboxamide templates by Kiselyov, Alexander S., Milligan, Daniel, Ouyang, Xiaohu

“…We have developed a series of novel potent 1-(2-(pyridin-4-yl)ethyl)-1 H-azole-5-carboxamides active against kinases VEGFR-2 and -1. Both specific and dual…”
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Arylphthalazines. Part 2: 1-(Isoquinolin-5-yl)-4-arylamino phthalazines as potent inhibitors of VEGF receptors I and II by Duncton, Matthew A.J., Piatnitski, Evgueni L., Katoch-Rouse, Reeti, Smith, Leon M., Kiselyov, Alexander S., Milligan, Daniel L., Balagtas, Chris, Wong, Wai C., Kawakami, Joel, Doody, Jacqueline F.

“…The synthesis and structure–activity relationships for a sub-class of arylphthalazine derivatives which have found use as inhibitors of VEGF receptors I and II…”
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Virtual and biomolecular screening converge on a selective agonist for GPR30 by Oprea, Tudor I, Prossnitz, Eric R, Bologa, Cristian G, Revankar, Chetana M, Young, Susan M, Edwards, Bruce S, Arterburn, Jeffrey B, Kiselyov, Alexander S, Parker, Matthew A, Tkachenko, Sergey E, Savchuck, Nikolay P, Sklar, Larry A

“…Estrogen is a hormone critical in the development, normal physiology and pathophysiology of numerous human tissues. The effects of estrogen have traditionally…”
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Chemistry of N-fluoropyridinium salts by Kiselyov, Alexander S

“…This tutorial review deals with developments in the chemistry of N-fluoropyridinium salts in the past decade, including both synthetic and mechanistic aspects…”
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Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery by Poceviciute, Roberta, Mitchell, Kenneth, Nikolakopoulou, Angeliki Maria, Cho, Suehyun K., Ma, Xiaobo, Chen, Phillip, Figueroa, Samantha, Sarmiento, Ethan J., Singh, Aryan, Hartstein, Oren, Loudon, William G., Cros, Florent, Kiselyov, Alexander S.

“…Viral vectors are an active area of research and development to treat diseases of the central nervous system (CNS). However, systemic delivery of…”
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DNA triple-helix specific intercalators as antigene enhancers: Unfused aromatic cations by Wilson, W. David, Tanious, Farial A, Mizan, Shaikh, Yao, Shijie, Kiselyov, Alexander S, Zon, Gerald, Strekowski, Lucjan

“…Triple-helical structures involving the interaction of an oligonucleotide third strand with a duplex nucleic acid sequence have recently gained attention as a…”
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3,4-Disubstituted isothiazoles: Novel potent inhibitors of VEGF receptors 1 and 2 by Kiselyov, Alexander S., Semenova, Marina, Semenov, Victor V.

“…Novel derivatives of isothiazoles are described as potent ATP-competitive inhibitors of vascular endothelial growth factor receptors I and II (VEGFR-1/2)…”
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(1,2,3-Triazol-4-yl)benzenamines: Synthesis and activity against VEGF receptors 1 and 2 by Kiselyov, Alexander S., Semenova, Marina, Semenov, Victor V.

“…Both synthesis and activity of the novel derivatives of (1,2,3-triazol-4-yl)benzenamines are described. Selected molecules of these series are potent and…”
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One-pot synthesis of polysubstituted pyrimidines by Kiselyov, Alexander S.

“…[Display omitted] A series of polysubstituted pyrimidines were synthesized from in situ generated α,β-unsaturated imines and the corresponding amidine or…”
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The o-Amino-Trifluoromethyl Functionality as a Novel Synthon for 4-Fluoroquinolines by Strekowski, Lucjan, Kiselyov, Alexander S, Hojjat, Maryam

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Oxadiazole derivatives as a novel class of antimitotic agents: Synthesis, inhibition of tubulin polymerization, and activity in tumor cell lines by Ouyang, Xiaohu, Piatnitski, Evgueni L., Pattaropong, Vatee, Chen, Xiaoling, He, Hai-Ying, Kiselyov, Alexander S., Velankar, Avdhoot, Kawakami, Joel, Labelle, Marc, Smith, Leon, Lohman, Julia, Lee, Sui Ping, Malikzay, Asra, Fleming, James, Gerlak, Jason, Wang, Ying, Rosler, Robin L., Zhou, Kai, Mitelman, Stan, Camara, Margarita, Surguladze, David, Doody, Jacqueline F., Tuma, M. Carolina

“…The synthesis, SAR studies, and pharmacokinetic properties of oxadiazole based tubulin inhibitor class are reported. This class of compounds binds to the…”
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Efficient Syntheses of the anti- and syn-Diol Epoxide Metabolites of the Carcinogenic Polycyclic Aromatic Hydrocarbon Benzo[g]chrysene by Kiselyov, Alexander S, Lee, Hongmee, Harvey, Ronald G

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Arylphthalazines as potent, and orally bioavailable inhibitors of VEGFR-2 by Duncton, Matthew A.J., Piatnitski Chekler, Eugene L., Katoch-Rouse, Reeti, Sherman, Dan, Wong, Wai C., Smith, Leon M., Kawakami, Joel K., Kiselyov, Alexander S., Milligan, Daniel L., Balagtas, Chris, Hadari, Yaron R., Wang, Ying, Patel, Sheetal N., Rolster, Robin L., Tonra, James R., Surguladze, David, Mitelman, Stan, Kussie, Paul, Bohlen, Peter, Doody, Jacqueline F.

“…A series of arylphthalazine derivatives were synthesized and evaluated as antagonists of VEGF receptor II (VEGFR-2). IM-094482 57, which was prepared in two…”
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Discovery of Dual VEGFR-2 and Tubulin Inhibitors with in Vivo Efficacy by Chekler, Eugene L. Piatnitski, Kiselyov, Alexander S, Ouyang, Xiaohu, Chen, Xiaoling, Pattaropong, Vatee, Wang, Ying, Tuma, M. Carolina, Doody, Jacqueline F

“…In an effort to develop potent, orally bioavailable compounds for the treatment of neoplastic diseases, we developed a class of dual VEGFR-2 kinase and tubulin…”
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Design and chemical synthesis of [1,2,4]triazol[1,5- c]pyrimidin-5-yl amines, a novel class of VEGFR-2 kinase inhibitors by Kiselyov, Alexander S., Piatnitski Chekler, Eugene L., Chernisheva, Natalia B., Salamandra, Lev K., Semenov, Victor V.

“…The Letter describes a facile approach to 7,8-dihydro[1,2,4]triazol[1,5- c]pyrimidin-5-yl amines, a novel class of potent inhibitors of vascular endothelial…”
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1-[4-(1 H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1 H-benzoimidazol-2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors by Pan, Weitao, Miao, Hua-Quan, Xu, Yong-Jiang, Navarro, Elizabeth C., Tonra, James R., Corcoran, Erik, Lahiji, Armin, Kussie, Paul, Kiselyov, Alexander S., Wong, Wai C., Liu, Hu

“…The development of small molecule heparanase inhibitor 7a (IC 50 = 0.27 μM) is reported. A novel class of 1-[4-(1 H-benzoimidazol-2-yl)-phenyl]-3-[4-(1…”
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Hetaryl imidazoles: A novel dual inhibitors of VEGF receptors I and II by Kiselyov, Alexander S., Semenova, Marina, Semenov, Victor V.

“…Novel potent derivatives of hetaryl imidazoles are described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display…”
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Synthesis and structure–activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors by Ouyang, Xiaohu, Chen, Xiaoling, Piatnitski, Evgueni L., Kiselyov, Alexander S., He, Hai-Ying, Mao, Yunyu, Pattaropong, Vatee, Yu, Yang, Kim, Ki H., Kincaid, John, Smith, Leon, Wong, Wai C., Lee, Sui Ping, Milligan, Daniel L., Malikzay, Asra, Fleming, James, Gerlak, Jason, Deevi, Dhanvanthri, Doody, Jacqueline F., Chiang, Hui-Hsien, Patel, Sheetal N., Wang, Ying, Rolser, Robin L., Kussie, Paul, Labelle, Marc, Tuma, M. Carolina

“…The synthesis and SAR studies on triazole-containing tubulin inhibitor class are reported. A novel triazole-containing chemical series was shown to inhibit…”
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4-(Azolylphenyl)-phthalazin-1-amines: Novel Inhibitors of VEGF Receptors I and II by Kiselyov, Alexander S., Semenov, Victor V., Milligan, Daniel

“…Novel potent derivatives of phthalazine are described as ATP‐competitive inhibitors of vascular endothelial growth factor receptors I and II (VEGFR‐1/2). A…”
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Arylphthalazines: Identification of a new phthalazine chemotype as inhibitors of VEGFR kinase by Piatnitski, Evgueni L., Duncton, Matthew A.J., Kiselyov, Alexander S., Katoch-Rouse, Reeti, Sherman, Dan, Milligan, Daniel L., Balagtas, Chris, Wong, Wai C., Kawakami, Joel, Doody, Jacqueline F.

“…The synthesis and structure–activity relationships for a new class of arylphthalazine derivatives, which have found use as inhibitors of VEGFR-2 kinase, are…”
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