Search Results - "Kisby, G E"

Biomarkers of oxidative stress and DNA damage in agricultural workers: A pilot study by Muniz, Juan F., McCauley, Linda, Scherer, J., Lasarev, M., Koshy, M., Kow, Y.W., Nazar-Stewart, Valle, Kisby, G.E.

“…Oxidative stress and DNA damage have been proposed as mechanisms linking pesticide exposure to health effects such as cancer and neurological diseases. A study…”
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A chronology of my graduate career under Dr. Dan Acosta by Kisby, G.E.

“…•Dr. Daniel Acosta, Jr is a scholar and mentor of many graduate students.•Dr. Acosta’s internationally-recognized research program and mentoring approach are…”
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DNA repair modulates the vulnerability of the developing brain to alkylating agents by Kisby, G.E., Olivas, A., Park, T., Churchwell, M., Doerge, D., Samson, L.D., Gerson, S.L., Turker, M.S.

“…Neurons of the developing brain are especially vulnerable to environmental agents that damage DNA (i.e., genotoxicants), but the mechanism is poorly…”
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Proteomic Analysis of the Genotoxicant Methylazoxymethanol (MAM)-Induced Changes in the Developing Cerebellum by Kisby, G. E, Standley, M, Park, T, Olivas, A, Fei, S, Jacob, T, Reddy, A, Lu, X, Pattee, P, Nagalla, S. R

“…The genotoxicant methylazoxymethanol (MAM) is a widely used developmental neurotoxin, and its glucoside is an etiological factor for western Pacific…”
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Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death by Kisby, G.E, Lesselroth, H, Olivas, A, Samson, L, Gold, B, Tanaka, K, Turker, M.S

“…Base-excision (BER) and nucleotide-excision (NER) repair play pivotal roles in protecting the genomes of dividing cells from damage by endogenous and exogenous…”
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Vervets and macaques: Similarities and differences in their responses to l-BMAA by Spencer, P.S., Garner, C.E., Palmer, V.S., Kisby, G.E.

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Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue by Kisby, Glen E, Milne, John, Sweatt, Curtis

“…OXIDATIVE stress is proposed to play a central role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Anti-oxidant enzymes and DNA repair proteins…”
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Molecular networks perturbed in a developmental animal model of brain injury by Kisby, G.E., Standley, M., Lu, X., O'Malley, J., Lin, B., Muniz, J., Luo, N.L., Pattee, P., Back, S.A., Nagalla, S.R.

“…Methylazoxymethanol (MAM) is widely used as a developmental neurotoxin and exposure to its glucoside (i.e., cycasin) is associated with the prototypical…”
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DAMAGE AND REPAIR OF NERVE CELL DNA IN TOXIC STRESS by KISBY, GLEN E., KABEL, HANS, HUGON, JACQUES, SPENCER, PETER

“…It is generally agreed that ALS/PDC is triggered by a disappearing environmental factor peculiar to the lifestyle of people of the western Pacific (i.e., Guam,…”
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Na+‐Dependent and Phlorizin‐Inhibitable Transport of Glucose and Cycasin in Brain Endothelial Cells by Matsuoka, Toshiyuki, Nishizaki, Tomoyuki, Kisby, Glen E.

“…: Although cycasin (methylazoxymethanol β‐d‐glucoside) is proposed to be a significant etiological factor for the prototypical neurodegenerative disorder…”
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In vitro neurotoxic and DNA-damaging properties of nitrogen mustard by Kisby, G. E., Springer, N., Spencer, P. S.

“…Sulfur mustard and nitrogen mustard (HN2) are reported to produce neurobehavioral and neuropathological changes in animals and humans, but the mechanisms are…”
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Content of the neurotoxins cycasin (methylazoxymethanol β-D-glucoside) and BMAA (β-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros by KISBY, G. E, ELLISON, M, SPENCER, P. S

“…Exposure to cycad seed kernel is an etiologic factor for the western Pacific amyotrophic lateral sclerosis (ALS) and parkinsonism-dementia complex (PDC)…”
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Cycad toxin-induced damage of rodent and human pancreatic β-cells by Eizirik, D.L., Kisby, G.E.

“…Environmental toxins may be risk factors for some forms of diabetes mellitus and neurodegenerative diseases. The medicinal and food use of seed from the cycad…”
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Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress by MEIRA, Lisiane B, DEVARAJ, Sridevi, KISBY, Glen E, BURNS, Dennis K, DANIEL, Russel L, HAMMER, Robert E, GRUNDY, Scott, JIALAL, Ishwarlal, FRIEDBERG, Errol C

“…Apurinic/apyrimidinic endonuclease is a key enzyme in the process of base excision repair, required for the repair of spontaneous base damage that arises as a…”
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Potential role of environmental genotoxic agents in diabetes mellitus and neurodegenerative diseases by Eizirik, Décio L., Spencer, Peter, Kisby, Glen E.

“…Epidemiological data suggest that environmental genotoxins are risk factors for some forms of diabetes mellitus and neurodegenerative diseases. The present…”
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Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region by SPENCER, P. S, KISBY, G. E, LUDOLPH, A. C, TETRUD, DR, KURLAND, DR, KOPIN, DR, LANGSTON, DR, DI MONTE, DR, LANG, DR, FORNO, DR

“…The western Pacific parkinsonism-dementia and amyotrophic lateral sclerosis complex is a prototypical neurodegenerative disorder found among inhabitants of…”
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Neurologic diseases associated with use of plant components with toxic potential by Spencer, P S, Ludolph, A C, Kisby, G E

“…Epidemics of neurotoxic disease in developing regions of the world are often associated with dietary dependence on plant components with inherent toxic…”
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Determination of beta-N-methylamino-L-alanine (BMAA) in plant (Cycas circinalis L.) and animal tissue by precolumn derivatization with 9-fluorenylmethyl chloroformate (FMOC) and reversed-phase high-performance liquid chromatography by Kisby, G E, Roy, D N, Spencer, P S

“…A high-performance liquid chromatography (HPLC) method is described for determining subpicomole concentrations of beta-N-methylamino-L-alanine (BMAA) in plant…”
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On the etiology and pathogenesis of chemically induced neurodegenerative disorders by Spencer, P S, Allen, C N, Kisby, G E, Ludolph, A C

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Lathyrism and western Pacific amyotrophic lateral sclerosis: etiology of short and long latency motor system disorders by Spencer, P S, Allen, C N, Kisby, G E, Ludolph, A C, Ross, S M, Roy, D N

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