Search Results - "Kis, Olena"

Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates by Kis, Olena, Kaedbey, Rayan, Chow, Signy, Danesh, Arnavaz, Dowar, Mark, Li, Tiantian, Li, Zhihua, Liu, Jessica, Mansour, Mark, Masih-Khan, Esther, Zhang, Tong, Bratman, Scott V., Oza, Amit M., Kamel-Reid, Suzanne, Trudel, Suzanne, Pugh, Trevor J.

“…The requirement for bone-marrow aspirates for genomic profiling of multiple myeloma poses an obstacle to enrolment and retention of patients in clinical…”
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P694: Case report: Unraveling a complex chromosomal rearrangement case using optical genome mapping by Ozcan, Zuhal, Shaw, Brandon, Kis, Olena, Fang, Xiaolan, Roberson, Jacquelyn, Washburn, Travis, Nyhuis, Mary

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pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions by Kis, Olena, Zastre, Jason A, Ramaswamy, Manisha, Bendayan, Reina

“…Human intestinal epithelium expresses a number of drug efflux and influx transporters that can restrict and/or facilitate intestinal drug uptake during…”
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Interactions between phytochemical components of Sutherlandia frutescens and the antiretroviral, atazanavir in vitro: implications for absorption and metabolism by Müller, Adrienne C, Patnala, Srinivas, Kis, Olena, Bendayan, Reina, Kanfer, Isadore

“…African traditional medicinal plants, such as Sutherlandia frutescens have the potential to interact pharmacokinetically with the protease inhibitor class of…”
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Sensitive tumour detection and classification using plasma cell-free DNA methylomes by Shen, Shu Yi, Singhania, Rajat, Fehringer, Gordon, Chakravarthy, Ankur, Roehrl, Michael H. A., Chadwick, Dianne, Zuzarte, Philip C., Borgida, Ayelet, Wang, Ting Ting, Li, Tiantian, Kis, Olena, Zhao, Zhen, Spreafico, Anna, Medina, Tiago da Silva, Wang, Yadon, Roulois, David, Ettayebi, Ilias, Chen, Zhuo, Chow, Signy, Murphy, Tracy, Arruda, Andrea, O’Kane, Grainne M., Liu, Jessica, Mansour, Mark, McPherson, John D., O’Brien, Catherine, Leighl, Natasha, Bedard, Philippe L., Fleshner, Neil, Liu, Geoffrey, Minden, Mark D., Gallinger, Steven, Goldenberg, Anna, Pugh, Trevor J., Hoffman, Michael M., Bratman, Scott V., Hung, Rayjean J., De Carvalho, Daniel D.

“…The use of liquid biopsies for cancer detection and management is rapidly gaining prominence 1 . Current methods for the detection of circulating tumour DNA…”
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The complexities of antiretroviral drug–drug interactions: role of ABC and SLC transporters by Kis, Olena, Robillard, Kevin, Chan, Gary N.Y, Bendayan, Reina

“…Treatment of human immunodeficiency virus (HIV) infection involves a combination of several antiviral agents belonging to different pharmacological classes…”
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Sclerosing TSC1 mutated renal cell carcinoma: An unusual pattern mimicking MITF family translocation renal cell carcinoma by Williamson, Sean R., Cardili, Leonardo, Whiteley, Lisa J., Sanchez, Jessica, Kis, Olena

“…The tuberous sclerosis genes and MTOR are increasingly being found to have important roles in novel subtypes of renal cancer, particularly emerging entities…”
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HIV-1 Alters Intestinal Expression of Drug Transporters and Metabolic Enzymes: Implications for Antiretroviral Drug Disposition by Kis, Olena, Sankaran-Walters, Sumathi, Hoque, M Tozammel, Walmsley, Sharon L, Dandekar, Satya, Bendayan, Reina

“…This study investigated the effects of HIV-1 infection and antiretroviral therapy (ART) on the expression of intestinal drug efflux transporters, i.e.,…”
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In Vitro and In Situ Evaluation of pH-Dependence of Atazanavir Intestinal Permeability and Interactions with Acid-Reducing Agents by Kis, Olena, Walmsley, Sharon L., Bendayan, Reina

“…Purpose The objectives of this study were to evaluate the effects of intestinal lumen pH, food intake, and acid-reducing agents on the intestinal permeability…”
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Spitz-Type Proliferative Nodules Arising Within a Large Congenital Melanocytic Nevus Harboring a Novel LMNA-RAF1 Fusion by Vellaichamy, Gautham, Poulik, Janet, Palanisamy, Nallasivam, Kis, Olena, Fang, Xiaolan, Al-Obaidy, Khaleel I, Shwayder, Tor A, Friedman, Ben J

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Raltegravir permeability across blood-tissue barriers and the potential role of drug efflux transporters by Hoque, M Tozammel, Kis, Olena, De Rosa, María F, Bendayan, Reina

“…The objectives of this study were to investigate raltegravir transport across several blood-tissue barrier models and the potential interactions with drug…”
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Role of Drug Efflux and Uptake Transporters in Atazanavir Intestinal Permeability and Drug-Drug Interactions by Kis, Olena, Zastre, Jason A., Hoque, Md. Tozammel, Walmsley, Sharon L., Bendayan, Reina

“…ABSTRACT Purpose To investigate the role of membrane-associated drug transporters in regulating the intestinal absorption of the HIV-1 protease inhibitor,…”
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Targeted-Capture Sequencing of the Immunoglobulin Locus to Detect V(D)J Rearrangements and Recurrent Illegitimate Translocations in Multiple Myeloma by Chow, Signy, Mulder, David, Kis, Olena, Trudel, Suzanne, Pugh, Trevor

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31 - Targeted-Capture Sequencing of the Immunoglobulin Locus to Detect V(D)J Rearrangements and Recurrent Illegitimate Translocations in Multiple Myeloma by Chow, Signy, Mulder, David, Kis, Olena, Trudel, Suzanne, Pugh, Trevor

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Drug transporters at brain barriers: expression and regulation by neurological disorders by Ashraf, Tamima, Kis, Olena, Banerjee, Nilasha, Bendayan, Reina

“…Drug transport in the central nervous system can be highly regulated by the expression of numerous influx and efflux transport proteins not only at the…”
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Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing by Chow, Signy, Kis, Olena, Mulder, David T, Danesh, Arnavaz, Bruce, Jeff, Wang, Ting Ting, Reece, Donna, Bhalis, Nizar, Neri, Paola, Sabatini, Peter Jb, Keats, Jonathan, Trudel, Suzanne, Pugh, Trevor J

“…Multiple myeloma is a plasma cell neoplasm characterized by clonal immunoglobulin V(D)J signatures and oncogenic immunoglobulin gene translocations. Additional…”
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Biomarker Driven Phase II Clinical Trial of Trametinib in Relapsed/Refractory Multiple Myeloma with Sequential Addition of the AKT Inhibitor, GSK2141795 at Time of Disease Progression to Overcome Treatment Failure: A Trial of the Princess Margaret Phase II Consortium by Trudel, Suzanne, Bahlis, Nizar J., Venner, Christopher P., Hay, Annette E, Kis, Olena, Chow, Signy, Li, Zhi Hua, Wei, Ellen Nong, Wang, Lisa, Tran, Christine, Udagani, Smitha, Blattler, Chantale, Pugh, Trevor J., Chen, Helen X, Oza, Amit

“…Activating mutations of the MAPK pathway are reported in over half of myeloma tumors. Experience with MEK inhibitors in solid tumors suggest that although…”
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Abstract 615: Noninvasive diagnosis of actionable mutations by deep sequencing of circulating tumor DNA in multiple myeloma by Kaedbey, Rayan, Kis, Olena, Danesh, Arnavaz, Dowar, Mark, Li, Tiantian, Li, Zhihua, Liu, Jessica, Mansour, Mark, Sukhai, Mahadeo, Zhang, Tong, Kamel-Reid, Suzanne, Pugh, Trevor J., Trudel, Suzanne

“…Abstract Background: Genome sequencing of multiple myeloma (MM) tumors has revealed recurrent mutations that serve as a fertile ground for targeted therapies…”
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Complexity of Antiretroviral Drug-Drug Interactions in the Intestine: Role of Membrane-Associated Drug Transporters by Kis, Olena

“…Complex antiretroviral therapy has introduced new obstacles in the treatment of HIV infection such as management of drug-induced toxicities and drug-drug…”
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Targeted Sequencing of Circulating Cell-free DNA in Multiple Myeloma Allows Analysis of Somatic Mutations, Copy Number Aberrations, and Translocations by Kis, Olena, Chow, Signy, Kaedbey, Rayan, Danesh, Arnavaz, Dowar, Mark, Li, Tiantian, Li, Zhihua, Liu, Jessica, Masih-Khan, Esther, Mulder, David, Zhang, Tong, Bratman, Scott, Oza, Amit, Kamel-Reid, Suzanne, Pugh, Trevor, Trudel, Suzanne

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