Search Results - "Kirwan, Jennifer"

Deep Learning-Assisted Peak Curation for Large-Scale LC-MS Metabolomics by Gloaguen, Yoann, Kirwan, Jennifer A, Beule, Dieter

“…Available automated methods for peak detection in untargeted metabolomics suffer from poor precision. We present NeatMS, which uses machine learning based on a…”
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Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative) by Kirwan, Jennifer A, Brennan, Lorraine, Broadhurst, David, Fiehn, Oliver, Cascante, Marta, Dunn, Warwick B, Schmidt, Michael A, Velagapudi, Vidya

“…The metabolome of any given biological system contains a diverse range of low molecular weight molecules (metabolites), whose abundances can be affected by the…”
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Quality assurance and quality control reporting in untargeted metabolic phenotyping: mQACC recommendations for analytical quality management by Kirwan, Jennifer A., Gika, Helen, Beger, Richard D., Bearden, Dan, Dunn, Warwick B., Goodacre, Royston, Theodoridis, Georgios, Witting, Michael, Yu, Li-Rong, Wilson, Ian D.

“…Background Demonstrating that the data produced in metabolic phenotyping investigations (metabolomics/metabonomics) is of good quality is increasingly seen as…”
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Comparing the Extraction Performance in Mouse Plasma of Different Biphasic Methods for Polar and Nonpolar Compounds by Gutmann, Friederike, Fritsche-Guenther, Raphaela, Dias, Daniela B., Kirwan, Jennifer A.

“…Many metabolomic studies are interested in both polar and nonpolar analyses. However, the available sample volume often precludes multiple separate…”
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Inflammation in Children with CKD Linked to Gut Dysbiosis and Metabolite Imbalance by Holle, Johannes, Bartolomaeus, Hendrik, Löber, Ulrike, Behrens, Felix, Bartolomaeus, Theda U P, Anandakumar, Harithaa, Wimmer, Moritz I, Vu, Dai Long, Kuhring, Mathias, Brüning, Ulrike, Maifeld, Andras, Geisberger, Sabrina, Kempa, Stefan, Schumacher, Fabian, Kleuser, Burkhard, Bufler, Philip, Querfeld, Uwe, Kitschke, Stefanie, Engler, Denise, Kuhrt, Leonard D, Drechsel, Oliver, Eckardt, Kai-Uwe, Forslund, Sofia K, Thürmer, Andrea, McParland, Victoria, Kirwan, Jennifer A, Wilck, Nicola, Müller, Dominik

“…CKD is characterized by a sustained proinflammatory response of the immune system, promoting hypertension and cardiovascular disease. The underlying mechanisms…”
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A study protocol to characterise pathophysiological and molecular markers of rheumatic heart disease and degenerative aortic stenosis using multiparametric cardiovascular imaging and multiomics techniques by Mutithu, Daniel W, Aremu, Olukayode O, Mokaila, Dipolelo, Bana, Tasnim, Familusi, Mary, Taylor, Laura, Martin, Lorna J, Heathfield, Laura J, Kirwan, Jennifer A, Wiesner, Lubbe, Adeola, Henry A, Lumngwena, Evelyn N, Manganyi, Rodgers, Skatulla, Sebastian, Naidoo, Richard, Ntusi, Ntobeko A B

“…Rheumatic heart disease (RHD), degenerative aortic stenosis (AS), and congenital valve diseases are prevalent in sub-Saharan Africa. Many knowledge gaps remain…”
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Metabolomics enables precision medicine: “A White Paper, Community Perspective” by Beger, Richard D., Dunn, Warwick, Schmidt, Michael A., Gross, Steven S., Kirwan, Jennifer A., Cascante, Marta, Brennan, Lorraine, Wishart, David S., Oresic, Matej, Hankemeier, Thomas, Broadhurst, David I., Lane, Andrew N., Suhre, Karsten, Kastenmüller, Gabi, Sumner, Susan J., Thiele, Ines, Fiehn, Oliver, Kaddurah-Daouk, Rima

“…Introduction: Background to metabolomics Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present…”
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Mechanical heterogeneity in a soft biomaterial niche controls BMP2 signaling by Brauer, Erik, Herrera, Aaron, Fritsche-Guenther, Raphaela, Görlitz, Sophie, Leemhuis, Hans, Knaus, Petra, Kirwan, Jennifer A., Duda, Georg N., Petersen, Ansgar

“…The extracellular matrix is known to impact cell function during regeneration by modulating growth factor signaling. However, how the mechanical properties and…”
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Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy by Denihan, Niamh M, Kirwan, Jennifer A, Walsh, Brian H, Dunn, Warwick B, Broadhurst, David I, Boylan, Geraldine B, Murray, Deirdre M

“…Elucidating metabolic effects of hypoxic-ischaemic encephalopathy (HIE) may reveal early biomarkers of injury and new treatment targets. This study uses…”
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Serum Starvation Accelerates Intracellular Metabolism in Endothelial Cells by Lorenz, Mario, Fritsche-Guenther, Raphaela, Bartsch, Cornelia, Vietzke, Angelika, Eisenberger, Alina, Stangl, Karl, Stangl, Verena, Kirwan, Jennifer A

“…Periods of low energy supply are challenging conditions for organisms and cells during fasting or famine. Although changes in nutrient levels in the blood are…”
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Analysis of adherent cell culture lysates with low metabolite concentrations using the Biocrates AbsoluteIDQ p400 HR kit by Fritsche-Guenther, Raphaela, Gloaguen, Yoann, Eisenberger, Alina, Kirwan, Jennifer A.

“…The Absolute IDQ p400 HR kit is a commercial product for targeted metabolomics. While the kit has been validated for human plasma and serum, adherent cell…”
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Concepts and Software Package for Efficient Quality Control in Targeted Metabolomics Studies: MeTaQuaC by Kuhring, Mathias, Eisenberger, Alina, Schmidt, Vanessa, Kränkel, Nicolle, Leistner, David M, Kirwan, Jennifer, Beule, Dieter

“…Targeted quantitative mass spectrometry metabolite profiling is the workhorse of metabolomics research. Robust and reproducible data are essential for…”
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Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage by Avery, Ellen G, Bartolomaeus, Hendrik, Rauch, Ariana, Chen, Chia-Yu, N’Diaye, Gabriele, Löber, Ulrike, Bartolomaeus, Theda U P, Fritsche-Guenther, Raphaela, Rodrigues, André F, Yarritu, Alex, Zhong, Cheng, Fei, Lingyan, Tsvetkov, Dmitry, Todiras, Mihail, Park, Joon-Keun, Markó, Lajos, Maifeld, András, Patzak, Andreas, Bader, Michael, Kempa, Stefan, Kirwan, Jennifer A, Forslund, Sofia K, Müller, Dominik N, Wilck, Nicola

“…Abstract Aims Hypertension (HTN) can lead to heart and kidney damage. The gut microbiota has been linked to HTN, although it is difficult to estimate its…”
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Shared and Distinct Gut Microbiota in Spondyloarthritis, Acute Anterior Uveitis, and Crohn's Disease by Essex, Morgan, Rios Rodriguez, Valeria, Rademacher, Judith, Proft, Fabian, Löber, Ulrike, Markó, Lajos, Pleyer, Uwe, Strowig, Till, Marchand, Jérémy, Kirwan, Jennifer A., Siegmund, Britta, Forslund, Sofia K., Poddubnyy, Denis

“…Objective Spondyloarthritis (SpA) is a group of immune‐mediated diseases highly concomitant with nonmusculoskeletal inflammatory disorders, such as acute…”
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Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators by Kühnisch, Jirko, Theisen, Simon, Dartsch, Josephine, Fritsche-Guenther, Raphaela, Kirchner, Marieluise, Obermayer, Benedikt, Bauer, Anna, Kahlert, Anne-Karin, Rothe, Michael, Beule, Dieter, Heuser, Arnd, Mertins, Philipp, Kirwan, Jennifer A, Berndt, Nikolaus, MacRae, Calum A, Hubner, Norbert, Klaassen, Sabine

“…Abstract Aims Mutation of the PRDM16 gene causes human dilated and non-compaction cardiomyopathy. The PRDM16 protein is a transcriptional regulator that…”
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Identification and validation of small molecule analytes in mouse plasma by liquid chromatography–tandem mass spectrometry: A case study of misidentification of a short-chain fatty acid with a ketone body by García-Rivera, Mariel A., Fernández-Ochoa, Álvaro, Brüning, Ulrike, Fritsche-Guenther, Raphaela, Kirwan, Jennifer A.

“…Recently, there has been growing interest in short-chain fatty acids (SCFA) and ketone bodies (KB) due to their potential use as biomarkers of health and…”
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SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology by Malik, Anna R., Szydlowska, Kinga, Nizinska, Karolina, Asaro, Antonino, van Vliet, Erwin A., Popp, Oliver, Dittmar, Gunnar, Fritsche-Guenther, Raphaela, Kirwan, Jennifer A., Nykjaer, Anders, Lukasiuk, Katarzyna, Aronica, Eleonora, Willnow, Thomas E.

“…VPS10P domain receptors emerge as central regulators of intracellular protein sorting in neurons with relevance for various brain pathologies. Here, we…”
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Biobanking for Metabolomics and Lipidomics in Precision Medicine by Kirwan, Jennifer A, Kaddurah-Daouk, Rima, Mitchell, Todd, Pischon, Tobias, Schmidt, Michael A, Velagapudi, Vidya

“…There is a likely trade-off between flexibility and specific requirements related to sample collection and storage. [...]the better it is known a priori what…”
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Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers by O'Boyle, Daragh S., Dunn, Warwick B., O'Neill, Donna, Kirwan, Jennifer A., Broadhurst, David I., Hallberg, Boubou, Boylan, Geraldine B., Murray, Deirdre M.

“…To validate our previously identified candidate metabolites, and to assess the ability of these metabolites to predict hypoxic-ischemic encephalopathy (HIE)…”
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Current Practices in LC-MS Untargeted Metabolomics: A Scoping Review on the Use of Pooled Quality Control Samples by Broeckling, Corey D., Beger, Richard D., Cheng, Leo L., Cumeras, Raquel, Cuthbertson, Daniel J., Dasari, Surendra, Davis, W. Clay, Dunn, Warwick B., Evans, Anne Marie, Fernández-Ochoa, Alvaro, Gika, Helen, Goodacre, Royston, Goodman, Kelli D., Gouveia, Goncalo J., Hsu, Ping-Ching, Kirwan, Jennifer A., Kodra, Dritan, Kuligowski, Julia, Lan, Renny Shang-Lun, Monge, María Eugenia, Moussa, Laura W., Nair, Sindhu G., Reisdorph, Nichole, Sherrod, Stacy D., Ulmer Holland, Candice, Vuckovic, Dajana, Yu, Li-Rong, Zhang, Bo, Theodoridis, Georgios, Mosley, Jonathan D.

“…Untargeted metabolomics is an analytical approach with numerous applications serving as an effective metabolic phenotyping platform to characterize small…”
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