Search Results - "Kirton, Stewart B"

Polymers Exhibiting Lower Critical Solution Temperatures as a Route to Thermoreversible Gelators for Healthcare by Cook, Michael T., Haddow, Peter, Kirton, Stewart B., McAuley, William J.

“…The ability to trigger changes to material properties with external stimuli, so‐called “smart” behavior, has enabled novel technologies for a wide range of…”
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New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival by Vilaboa, Nuria, Boré, Alba, Martin-Saavedra, Francisco, Bayford, Melanie, Winfield, Natalie, Firth-Clark, Stuart, Kirton, Stewart B, Voellmy, Richard

“…Comparative modeling of the DNA-binding domain of human HSF1 facilitated the prediction of possible binding pockets for small molecules and definition of…”
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The Influence of Oily Vehicle Composition and Vehicle-Membrane Interactions on the Diffusion of Model Permeants across Barrier Membranes by Najib, Omaima N, Martin, Gary P, Kirton, Stewart B, Botha, Michelle J, Sallam, Al-Sayed, Murnane, Darragh

“…In many instances, one or more components of a pharmaceutical or cosmetic formulation is an oil. The aims of this study were two-fold. First, to examine the…”
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Multivariate Analytical Approaches to Identify Key Molecular Properties of Vehicles, Permeants and Membranes That Affect Permeation through Membranes by Najib, Omaima N, Kirton, Stewart B, Martin, Gary P, Botha, Michelle J, Sallam, Al-Sayed, Murnane, Darragh

“…There has been considerable recent interest in employing computer models to investigate the relationship between the structure of a molecule and its dermal…”
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The benefits of in silico modeling to identify possible small-molecule drugs and their off-target interactions by Zloh, Mire, Kirton, Stewart B

“…The research into the use of small molecules as drugs continues to be a key driver in the development of molecular databases, computer-aided drug design…”
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Revisiting the General Solubility Equation: In Silico Prediction of Aqueous Solubility Incorporating the Effect of Topographical Polar Surface Area by Ali, Jogoth, Camilleri, Patrick, Brown, Marc B, Hutt, Andrew J, Kirton, Stewart B

“…The General Solubility Equation (GSE) is a QSPR model based on the melting point and log P of a chemical substance. It is used to predict the aqueous…”
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NPS detection in prison: A systematic literature review of use, drug form, and analytical approaches by Vaccaro, Giorgia, Massariol, Anna, Guirguis, Amira, Kirton, Stewart B., Stair, Jacqueline L.

“…This paper presents a systematic literature review on the detection of new psychoactive substances (NPS) in prison settings. It includes the most frequently…”
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Thermoresponsive Triblock‐Copolymers of Polyethylene Oxide and Polymethacrylates: Linking Chemistry, Nanoscale Morphology, and Rheological Properties by da Silva, Marcelo Alves, Haddow, Peter, Kirton, Stewart B., McAuley, William J., Porcar, Lionel, Dreiss, Cécile A., Cook, Michael T.

“…Thermoreversible gels switch from a free‐flowing liquid state to an elastic gel mesophase upon warming, displaying the reverse transition upon cooling. While…”
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A drug-incorporated-microparticle-eggshell-membrane-scaffold (DIMES) dressing: A novel biomaterial for localised wound regeneration by Mensah, Rosemond A, Cook, Michael T, Kirton, Stewart B, Hutter, Victoria, Chau, David Yi San

“…[Display omitted] Chronic wounds affect millions of people annually and have emotional and financial implications in addition to health issues. The current…”
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Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells by Camara, Ramatoulie, Ogbeni, Deborah, Gerstmann, Lisa, Ostovar, Mehrnoosh, Hurer, Ellie, Scott, Mark, Mahmoud, Nasir G., Radon, Tomasz, Crnogorac-Jurcevic, Tatjana, Patel, Pryank, Mackenzie, Louise S., Chau, David Y.S., Kirton, Stewart B., Rossiter, Sharon

“…S100P, a calcium-binding protein, is known to advance tumor progression and metastasis in pancreatic and several other cancers. Herein is described the in…”
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The eggshell membrane: A potential biomaterial for corneal wound healing by Mensah, Rosemond A, Jo, Seung Bin, Kim, Hoon, Park, Sung-Min, Patel, Kapil D, Cho, Kyong J, Cook, Michael T, Kirton, Stewart B, Hutter, Victoria, Sidney, Laura E, Alves-Lima, Decio, Lin, Hungyen, Lee, Jung-Hwan, Kim, Hae-Won, Chau, David YS

“…The eggshell membrane (ESM) is an abundant resource with innate complex structure and composition provided by nature. With at least 60 million tonnes of hen…”
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In Silico Prediction of Aqueous Solubility Using Simple QSPR Models: The Importance of Phenol and Phenol-like Moieties by Ali, Jogoth, Camilleri, Patrick, Brown, Marc B, Hutt, Andrew J, Kirton, Stewart B

“…Recently the authors published a robust QSPR model of aqueous solubility which exploited the computationally derived molecular descriptor topographical polar…”
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Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks by Muddle, Joanna, Kirton, Stewart B, Parisini, Irene, Muddle, Andrew, Murnane, Darragh, Ali, Jogoth, Brown, Marc, Page, Clive, Forbes, Ben

“…Dry powder inhalers are increasingly popular for delivering drugs to the lungs for the treatment of respiratory diseases, but are complex products with…”
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Polymer Architecture Effects on Poly(N,N‐Diethyl Acrylamide)‐b‐Poly(Ethylene Glycol)‐b‐Poly(N,N‐Diethyl Acrylamide) Thermoreversible Gels and Their Evaluation as a Healthcare Material by Haddow, Peter J., da Silva, Marcelo A., Kaldybekov, Daulet B., Dreiss, Cecile A., Hoffman, Ewelina, Hutter, Victoria, Khutoryanskiy, Vitaliy V., Kirton, Stewart B., Mahmoudi, Najet, McAuley, William J., Cook, Michael T.

“…Thermoreversible gels which transition between liquid‐like and solid‐like states when warmed have enabled significant novel healthcare technologies…”
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In Silico Investigations into the Selectivity of Psychoactive and New Psychoactive Substances in Monoamine Transporters by Botha, Michelle J., Kirton, Stewart B.

“…New psychoactive substances (NPS) are a group of compounds that mimic the effects of illicit substances. A range of NPS have been shown to interact with the…”
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Detection of newly emerging psychoactive substances using Raman spectroscopy and chemometrics by Calvo-Castro, Jesus, Guirguis, Amira, Samaras, Eleftherios G, Zloh, Mire, Kirton, Stewart B, Stair, Jacqueline L

“…A novel approach for the identification of New Psychoactive Substances (NPS) by means of Raman spectroscopy coupled with Principal Components Analysis (PCA)…”
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Elemental fingerprinting of Hypericum perforatum (St John’s Wort) herb and preparations using ICP-OES and chemometrics by Owen, Jade D., Kirton, Stewart B., Evans, Sara J., Stair, Jacqueline L.

“…[Display omitted] •Evaluation of 54 samples (i.e., herb, capsule and tablet) from worldwide origin.•The elemental profile plus PCA delineated between herb,…”
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Using Structured Chemistry Examinations (SChemEs) As an Assessment Method To Improve Undergraduate Students’ Generic, Practical, and Laboratory-Based Skills by Kirton, Stewart B, Al-Ahmad, Abdullah, Fergus, Suzanne

“…Increase in tuition fees means there will be renewed pressure on universities to provide “value for money” courses that provide extensive training in both…”
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Drowning in diversity? A systematic way of clustering and selecting a representative set of new psychoactive substances by Zloh, Mire, Samaras, Eleftherios G., Calvo-Castro, Jesus, Guirguis, Amira, Stair, Jacqueline L., Kirton, Stewart B.

“…New psychoactive substances (NPS) can be generally described as a set of compounds that have been designed to mimic the effects of illegal recreational drugs,…”
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Establishing the importance of oil-membrane interactions on the transmembrane diffusion of physicochemically diverse compounds by Najib, Omaima N., Martin, Gary P., Kirton, Stewart B., Sallam, Al-Sayed, Murnane, Darragh

“…[Display omitted] The diffusion process through a non-porous barrier membrane depends on the properties of the drug, vehicle and membrane. The aim of the…”
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