Search Results - "Kirton, Hannah M"

Epac2-Rap1 Signaling Regulates Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias by Yang, Zhaokang, Kirton, Hannah M, Al-Owais, Moza, Thireau, Jérôme, Richard, Sylvain, Peers, Chris, Steele, Derek S

“…In the heart, β -adrenergic signaling involves cyclic adenosine monophosphate (cAMP) acting via both protein kinase-A (PKA) and exchange protein directly…”
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Flecainide induces a sustained countercurrent dependent effect on RyR2 in permeabilized WT ventricular myocytes but not in intact cells by Steer, Emma J, Yang, Zhaokang, Al-Owais, Moza M, Kirton, Hannah M, White, Edward, Steele, Derek S

“…While flecainide is now an accepted treatment for arrhythmias associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), its mechanism of…”
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Super-Resolution Analysis of the Origins of the Elementary Events of ER Calcium Release in Dorsal Root Ganglion Neurons by Hurley, Miriam E, Shah, Shihab S, Sheard, Thomas M D, Kirton, Hannah M, Steele, Derek S, Gamper, Nikita, Jayasinghe, Izzy

“…Coordinated events of calcium (Ca ) released from the endoplasmic reticulum (ER) are key second messengers in excitable cells. In pain-sensing dorsal root…”
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Action potential responses to changes in stimulation frequency and isoproterenol in rat ventricular myocytes by Howlett, Luke A., Kirton, Hannah M., Al‐Owais, Moza M., Steele, Derek, Lancaster, Matthew K.

“…Purpose Current understanding of ventricular action potential adaptation to physiological stress is generally based on protocols using non‐physiological rates…”
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A correlative super-resolution protocol to visualise structural underpinnings of fast second-messenger signalling in primary cell types by Hurley, Miriam E., Sheard, Thomas M.D., Norman, Ruth, Kirton, Hannah M., Shah, Shihab S., Pervolaraki, Eleftheria, Yang, Zhaokang, Gamper, Nikita, White, Ed, Steele, Derek, Jayasinghe, Izzy

“…•The imaging protocol visualises intracellular calcium signals and their sources.•It correlates calcium spark TIRF images with DNA-PAINT images of RyR…”
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Three-Dimensional and Chemical Mapping of Intracellular Signaling Nanodomains in Health and Disease with Enhanced Expansion Microscopy by Sheard, Thomas M. D, Hurley, Miriam E, Colyer, John, White, Ed, Norman, Ruth, Pervolaraki, Eleftheria, Narayanasamy, Kaarjel K, Hou, Yufeng, Kirton, Hannah M, Yang, Zhaokang, Hunter, Liam, Shim, Jung-uk, Clowsley, Alexander H, Smith, Andrew J, Baddeley, David, Soeller, Christian, Colman, Michael A, Jayasinghe, Izzy

“…Nanodomains are intracellular foci which transduce signals between major cellular compartments. One of the most ubiquitous signal transducers, the ryanodine…”
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A key role for peroxynitrite‐mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide–induced proarrhythmic early afterdepolarizations by Al‐Owais, Moza M., Hettiarachchi, Nishani T., Kirton, Hannah M., Hardy, Matthew E., Boyle, John P., Scragg, Jason L., Steele, Derek S., Peers, Chris

“…Exposure to CO causes early afterdepolarization arrhythmias. Previous studies in rats have indicated that arrhythmias arose as a result of augmentation of the…”
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The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the β1-adrenergic signaling pathway by Yang, Zhaokang, Kirton, Hannah M, MacDougall, David A, Boyle, John P, Deuchars, James, Frater, Brenda, Ponnambalam, Sreenivasan, Hardy, Matthew E, White, Edward, Calaghan, Sarah C, Peers, Chris, Steele, Derek S

“…Ca(2+) release from the Golgi apparatus regulates key functions of the organelle, including vesicle trafficking. We found that the Golgi apparatus was the…”
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Transient overexpression of genes in neurons using nucleofection by Kirton, Hannah M, Pettinger, Louisa, Gamper, Nikita

“…Nucleofection is a transfection method used to introduce substrates such as cDNA plasmids into primary cells or other cell lines. The method can be…”
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Competitive Interactions of Kv7 Channel Carboxy-Termini with PIP2 and Calmodulin by Kirton, Hannah M.

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Conditions that Promote Golgi Ca2+ Release Facilitate Trafficking of VEGFR-1 to the Surface Membrane in Rat Ventricular Myocytes by Kirton, Hannah M., Yang, Zhaokang, Steele, Derek S.

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The EPAC2 Inhibitor ESI-05 Prolongs the Action Potential and Increases Susceptibility to EAD Arrhythmias by Kirton, Hannah M., Al-Owais, Moza, Peers, Chris, Steele, Derek S.

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Optical Superresolution Analysis of Intracellular Calcium Handling Proteins and Correlating Calcium Signal Morphology by Hurley, Miriam E., Sheard, Thomas M., Norman, Ruth, Kirton, Hannah M., Shah, Shihab S., Pervolaraki, Eleftheria, Yang, Zhaokang, Steele, Derek S., Gamper, Nikita, White, Ed, Jayasinghe, Izzy

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Phosphodiesterase Inhibition Leads to Activation of Epac and Stimulation of Ca2+ Release from both the Golgi Apparatus and the SR by Kirton, Hannah M., Yang, Zhaokang, Steele, Derek S.

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Epac2-Rap1 Signaling Influences Reactive Oxygen Species Production and Susceptibility to Cardiac Arrhythmias by Yang, Zhaokang, Kirton, Hannah M., Al-Owais, Moza, Peers, Chris, Steele, Derek S.

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Bin-1 Expression in Normal Rat Cardiac Myocytes and in Myocytes with Reduced T-Tubule Density Due to Cell Culture or Heart Failure by Kirton, Hannah M., Hardy, Matthew, White, Edward, Steele, Derek

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