Search Results - "Kirst, Herbert A"

The spinosyn family of insecticides: realizing the potential of natural products research by Kirst, Herbert A

“…The spinosyns are a large family of unprecedented compounds produced from fermentation of two species of Saccharopolyspora . Their core structure is a…”
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12th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds (ICCA-12) by Kirst, Herbert A

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Prologue to the Special Issue on Synthesis by Kirst, Herbert A, Takahashi, Yoshikazu

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Developing new antibacterials through natural product research by Kirst, Herbert A

“…Natural products have long been instrumental for discovering antibiotics, but many pharmaceutical companies abandoned this field and new antibiotics declined…”
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Engineering Conferences International (ECI) Natural Products Discovery and Production II: Celebrating the Successes of Traditional and Novel Culture Sources Whistler, British Columbia, Canada June 22≈26, 2008 by Kirst, Herbert A

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Circumventing resistance to anti-infective agents by Kirst, Herbert A

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13th International Conference on the Chemistry of Antibiotics and Other Bioactive Compounds (ICCA-13) by Kirst, Herbert A

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New macrolide, lincosaminide and streptogramin B antibiotics by Kirst, Herbert A

“…New antibiotics are needed to overcome microbial resistance and to improve on the therapeutic index and clinical effectiveness of existing agents. This review…”
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Recent derivatives from smaller classes of fermentation-derived antibacterials by Kirst, Herbert A

“…New antibiotics, without cross-resistance to existing agents, are needed to treat infections caused by increasingly resistant pathogens and to improve the…”
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Synthesis and evaluation of a series of 1,4-Diarylbutadienes for anticoccidial activity by Gage, Jennifer L, Kirst, Herbert A, O'Neil, Deirdre, David, Bridget A, Smith, Charles K, Naylor, Sharon A

“…During the course of a collaborative screening program, a set of 1-phenyl-4-pyridyl-butadienes was found to exhibit in vitro activity against Eimeria tenella…”
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Antibiotics versus resistant bacteria: a continual challenge by Kirst, Herbert A

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11th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds (ICCA-11) Donostia-San Sebastian, Spain 29 September-2 October 2009 by Kirst, Herbert A

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Synthesis and in vitro antimicrobial activity of 3-keto 16-membered macrolides derived from tylosin by Creemer, Lawrence C, Toth, John E, Kirst, Herbert A

“…Several series of 14-membered ketolides derived from erythromycin exhibit useful antimicrobial activity against macrolide-resistant bacteria. To determine if…”
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Engineering Conferences International (ECI) Natural Products Discovery and Production II by Kirst, Herbert A

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Historical yearly usage of vancomycin by Kirst, H A, Thompson, D G, Nicas, T I

“…The reasons for the emergence and spread of vancomycin-resistant enterococci are not yet fully understood. Nevertheless, various hypotheses and proposals which…”
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Synthesis and in Vitro Evaluation of New Wortmannin Esters:  Potent Inhibitors of Phosphatidylinositol 3-Kinase by Creemer, Lawrence C, Kirst, Herbert A, Vlahos, Chris J, Schultz, Richard M

“…New C-11 esters of the fermentation product wortmannin have been synthesized, with some of them further derivatized at C-17. The new esters show greater…”
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Synthesis and insecticidal activity of spinosyn analogs functionally altered at the 2'-,3'- and 4'-positions of the rhamnose moiety by Creemer, L C, Kirst, H A, Paschal, J W, Worden, T V

“…In an effort to increase the insecticidal activity of the spinosyn family of naturally occurring macrolides, the 2'-, 3'- and 4'-O-desmethyl-O-acetyl analogs…”
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Biological activity of the spinosyns, new fermentation derived insect control agents, on tobacco budworm (Lepidoptera: Noctuidae) larvae by Sparks, T.C, Thompson, G.D, Kirst, H.A, Hertlein, M.B, Larson, L.L, Worden, T.V, Thibault, S.T

“…The spinosyns are a new class of fermentation-derived tetracyclic-macrolide insect control agents that are active against lepidopterous pests such as the…”
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Genetic engineering of aminodeoxyhexose biosynthesis in Streptomyces fradiae by Cundliffe, Eric, Butler, Andrew R, Kiehl, Douglas E, Kirst, Herbert A, Bate, Neil

“…The antibacterial properties of macrolide antibiotics (such as erythromycin, tylosin, and narbomycin) depend ultimately on the glycosylation of otherwise…”
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Structure of the new spiroketal-macrolide A82548A by Kirst, H A, Larsen, S H, Paschal, J W, Occolowitz, J L, Creemer, L C, Steiner, J L, Lobkovsky, E, Clardy, J

“…A new member of the spiroketal-containing macrolide class of fermentation-derived natural products was isolated from mycelial extracts of Streptomyces…”
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