Search Results - "Kirshenbaum, Kent"

Folded biomimetic oligomers for enantioselective catalysis by Maayan, Galia, Ward, Michael D, Kirshenbaum, Kent

“…Many naturally occurring biopolymers (i.e., proteins, RNA, DNA) owe their unique properties to their well-defined three-dimensional structures. These…”
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Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition by Battigelli, Alessia, Kim, Jae Hong, Dehigaspitiya, Dilani C, Proulx, Caroline, Robertson, Ellen J, Murray, Daniel J, Rad, Behzad, Kirshenbaum, Kent, Zuckermann, Ronald N

“…Glycoproteins adhered on the cellular membrane play a pivotal role in a wide range of cellular functions. Their importance is particularly relevant in the…”
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Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes by Andreev, Konstantin, Martynowycz, Michael W., Huang, Mia L., Kuzmenko, Ivan, Bu, Wei, Kirshenbaum, Kent, Gidalevitz, David

“…Hydrophobic interactions govern specificity for natural antimicrobial peptides. No such relationship has been established for synthetic peptoids that mimic…”
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Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer by Schneider, Jeffrey A., Craven, Timothy W., Kasper, Amanda C., Yun, Chi, Haugbro, Michael, Briggs, Erica M., Svetlov, Vladimir, Nudler, Evgeny, Knaut, Holger, Bonneau, Richard, Garabedian, Michael J., Kirshenbaum, Kent, Logan, Susan K.

“…New chemical inhibitors of protein–protein interactions are needed to propel advances in molecular pharmacology. Peptoids are peptidomimetic oligomers with the…”
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Discovery of Stable and Selective Antibody Mimetics from Combinatorial Libraries of Polyvalent, Loop-Functionalized Peptoid Nanosheets by Kim, Jae Hong, Kim, Samuel C, Kline, Mark A, Grzincic, Elissa M, Tresca, Blakely W, Cardiel, Joshua, Karbaschi, Mohsen, Dehigaspitiya, Dilani C, Chen, Yulin, Udumula, Venkatareddy, Jian, Tengyue, Murray, Daniel J, Yun, Lisa, Connolly, Michael D, Liu, Jianfang, Ren, Gang, Chen, Chun-Long, Kirshenbaum, Kent, Abate, Adam R, Zuckermann, Ronald N

“…The ability of antibodies to bind a wide variety of analytes with high specificity and high affinity makes them ideal candidates for therapeutic and diagnostic…”
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De novo structure prediction and experimental characterization of folded peptoid oligomers by Butterfoss, Glenn L., Yoo, Barney, Jaworski, Jonathan N., Chorny, Ilya, Dill, Ken A., Zuckermann, Ronald N., Bonneau, Richard, Kirshenbaum, Kent, Voelz, Vincent A.

“…Peptoid molecules are biomimetic oligomers that can fold into unique three-dimensional structures. As part of an effort to advance computational design of…”
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A Preliminary Survey of the Peptoid Folding Landscape by Butterfoss, Glenn L, Renfrew, P. Douglas, Kuhlman, Brian, Kirshenbaum, Kent, Bonneau, Richard

“…We present an analysis of the conformational preferences of N-substituted glycine peptoid oligomers. We survey the backbone conformations observed in…”
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Biomimetic peptoid oligomers as dual-action antifreeze agents by Huang, Mia L, Ehre, David, Jiang, Qi, Hu, Chunhua, Kirshenbaum, Kent, Ward, Michael D

“…The ability of natural peptides and proteins to influence the formation of inorganic crystalline materials has prompted the design of synthetic compounds for…”
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A Rotamer Library to Enable Modeling and Design of Peptoid Foldamers by Renfrew, P. Douglas, Craven, Timothy W, Butterfoss, Glenn L, Kirshenbaum, Kent, Bonneau, Richard

“…Peptoids are a family of synthetic oligomers composed of N-substituted glycine units. Along with other “foldamer” systems, peptoid oligomer sequences can be…”
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Altered steady state and activity-dependent de novo protein expression in fragile X syndrome by Bowling, Heather, Bhattacharya, Aditi, Zhang, Guoan, Alam, Danyal, Lebowitz, Joseph Z., Bohm-Levine, Nathaniel, Lin, Derek, Singha, Priyangvada, Mamcarz, Maggie, Puckett, Rosemary, Zhou, Lili, Aryal, Sameer, Sharp, Kevin, Kirshenbaum, Kent, Berry-Kravis, Elizabeth, Neubert, Thomas A., Klann, Eric

“…Whether fragile X mental retardation protein (FMRP) target mRNAs and neuronal activity contributing to elevated basal neuronal protein synthesis in fragile X…”
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Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts by Kraja, Iv, Bing, Renjie, Hiwatashi, Nao, Rousseau, Bernard, Nalband, Danielle, Kirshenbaum, Kent, Branski, Ryan C.

“…Objective An obstacle to clinical use of RNA‐based gene suppression is instability and inefficiency of current delivery modalities. Nanoparticle delivery…”
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Intrinsic bioconjugation for site-specific protein PEGylation at N-terminal serine by Levine, Paul M, Craven, Timothy W, Bonneau, Richard, Kirshenbaum, Kent

“…Recently developed chemical ligation protocols were elaborated for rapid N-terminal protein PEGylation. We introduce a PEG-salicylaldehyde ester and…”
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Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrPSc and Targeting PrPSc for Lysosomal Degradation by Pankiewicz, Joanna E., Sanchez, Sandrine, Kirshenbaum, Kent, Kascsak, Regina B., Kascsak, Richard J., Sadowski, Martin J.

“…PrP Sc is an infectious and disease-specific conformer of the prion protein, which accumulation in the CNS underlies the pathology of prion diseases. PrP Sc…”
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Viral Nanoparticles Donning a Paramagnetic Coat:  Conjugation of MRI Contrast Agents to the MS2 Capsid by Anderson, Elizabeth A, Isaacman, Steven, Peabody, David S, Wang, Edwin Y, Canary, James W, Kirshenbaum, Kent

“…A nanoparticle magnetic resonance imaging (MRI) contrast agent was developed by conjugation of more than 500 gadolinium chelate groups onto a viral capsid. The…”
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Nanoparticle delivery of RNA‐based therapeutics to alter the vocal fold tissue response to injury by Hiwatashi, Nao, Kraja, Iv, Benedict, Peter A., Dion, Gregory R., Bing, Renjie, Rousseau, Bernard, Amin, Milan R., Nalband, Danielle M., Kirshenbaum, Kent, Branski, Ryan C.

“…Objectives/Hypothesis Our laboratory and others hypothesized that Smad3 is a principle mediator of the fibrotic phenotype in the vocal folds (VFs), and we…”
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Conformational Rearrangements by Water-Soluble Peptoid Foldamers by Shin, Sung Bin Y, Kirshenbaum, Kent

“…Peptoids are a family of N-substituted glycine oligomers that are capable of forming stable helical structures. We seek peptoid monomers that can establish a…”
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Adding diverse noncanonical backbones to rosetta: enabling peptidomimetic design by Drew, Kevin, Renfrew, P Douglas, Craven, Timothy W, Butterfoss, Glenn L, Chou, Fang-Chieh, Lyskov, Sergey, Bullock, Brooke N, Watkins, Andrew, Labonte, Jason W, Pacella, Michael, Kilambi, Krishna Praneeth, Leaver-Fay, Andrew, Kuhlman, Brian, Gray, Jeffrey J, Bradley, Philip, Kirshenbaum, Kent, Arora, Paramjit S, Das, Rhiju, Bonneau, Richard

“…Peptidomimetics are classes of molecules that mimic structural and functional attributes of polypeptides. Peptidomimetic oligomers can frequently be…”
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N-Naphthyl Peptoid Foldamers Exhibiting Atropisomerism by Paul, Bishwajit, Butterfoss, Glenn L, Boswell, Mikki G, Huang, Mia L, Bonneau, Richard, Wolf, Christian, Kirshenbaum, Kent

“…We introduce peptoid oligomers incorporating N-(1)-naphthyl glycine monomers. Axial chirality was established due to restricted rotation about the C–N(aryl)…”
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Heterocyclic amines for the construction of peptoid oligomers bearing multi-dentate ligands by Maayan, Galia, Yoo, Barney, Kirshenbaum, Kent

“…Peptoids are oligomers of N-substituted glycine that can be readily assembled using haloacetic acids and primary amines as synthons. Here, we report the…”
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Conformational preferences of peptide-peptoid hybrid oligomers by Butterfoss, Glenn L., Drew, Kevin, Renfrew, P. Douglas, Kirshenbaum, Kent, Bonneau, Richard

“…ABSTRACT Peptomers are oligomeric molecules composed of both α‐amino acids and N‐substituted glycine monomers, thus creating a hybrid of peptide and peptoid…”
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