Search Results - "Kirsh, Jacob M"
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Structural Characterization of Fluorescent Proteins Using Tunable Femtosecond Stimulated Raman Spectroscopy
Published in International journal of molecular sciences (26-07-2023)“…The versatile functions of fluorescent proteins (FPs) as fluorescence biomarkers depend on their intrinsic chromophores interacting with the protein…”
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Nitrile Infrared Intensities Characterize Electric Fields and Hydrogen Bonding in Protic, Aprotic, and Protein Environments
Published in Journal of the American Chemical Society (04-05-2022)“…Nitriles are widely used vibrational probes; however, the interpretation of their IR frequencies is complicated by hydrogen bonding (H-bonding) in protic…”
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Critical Evaluation of Polarizable and Nonpolarizable Force Fields for Proteins Using Experimentally Derived Nitrile Electric Fields
Published in Journal of the American Chemical Society (13-03-2024)“…Molecular dynamics (MD) simulations are frequently carried out for proteins to investigate the role of electrostatics in their biological function. The choice…”
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Protein protic and aprotic interactions systematically mapped via IR spectroscopy and polarizable molecular dynamics
Published in Biophysical journal (10-02-2023)Get full text
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Synthesis and Characterization of (pyNO−)2GaCl: A Redox-Active Gallium Complex
Published in Inorganics (01-06-2018)“…We report the synthesis of a gallium complex incorporating redox-active pyridyl nitroxide ligands. The (pyNO−)2GaCl complex was prepared in 85% yield via a…”
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Carbon-deuterium bonds as reporters of electric fields in solvent and protein environments
Published in Biophysical journal (10-02-2023)Get full text
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Nitrile IR intensities directly measure electric fields in protic and non-protic environments
Published in Biophysical journal (11-02-2022)Get full text
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A qualitative study of what motivates and enables climate-engaged physicians in Canada to engage in health-care sustainability, advocacy, and action
Published in The Lancet. Planetary health (01-02-2023)“…Increasing numbers of health-care professionals are aware of the need to deliver low-carbon sustainable health systems. We aimed to explore how physicians can…”
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