Search Results - "Kirschner, Daniel A."

Claudin-11 Tight Junctions in Myelin Are a Barrier to Diffusion and Lack Strong Adhesive Properties by Denninger, Andrew R., Breglio, Andrew, Maheras, Kathleen J., LeDuc, Geraldine, Cristiglio, Viviana, Demé, Bruno, Gow, Alexander, Kirschner, Daniel A.

“…The radial component is a network of interlamellar tight junctions (TJs) unique to central nervous system myelin. Ablation of claudin-11, a TJ protein, results…”
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Constitutively Active Akt Induces Enhanced Myelination in the CNS by Flores, Ana I, Narayanan, S. Priyadarshini, Morse, Emily N, Shick, H. Elizabeth, Yin, Xinghua, Kidd, Grahame, Avila, Robin L, Kirschner, Daniel A, Macklin, Wendy B

“…The serine/threonine kinase Akt regulates multiple cellular functions. The current studies identify a new role for Akt in CNS myelination. In earlier studies…”
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Myelin organization in the nodal, paranodal, and juxtaparanodal regions revealed by scanning x-ray microdiffraction by Inouye, Hideyo, Liu, Jiliang, Makowski, Lee, Palmisano, Marilena, Burghammer, Manfred, Riekel, Christian, Kirschner, Daniel A

“…X-ray diffraction has provided extensive information about the arrangement of lipids and proteins in multilamellar myelin. This information has been limited to…”
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The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study by Cantu’, Laura, Colombo, Laura, Stoilova, Tatiana, Demé, Bruno, Inouye, Hideyo, Booth, Rachel, Rondelli, Valeria, Di Fede, Giuseppe, Tagliavini, Fabrizio, Del Favero, Elena, Kirschner, Daniel A., Salmona, Mario

“…We have described a novel C-to-T mutation in the APP gene that corresponds to an alanine to valine substitution at position 673 in APP (A673V), or position 2…”
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The Formation of Straight and Twisted Filaments from Short Tau Peptides by Goux, Warren J., Kopplin, Lauren, Nguyen, Anh D., Leak, Kathryn, Rutkofsky, Marni, Shanmuganandam, Vasanthi D., Sharma, Deepak, Inouye, Hideyo, Kirschner, Daniel A.

“…We studied fibril formation in a family of peptides based on PHF6 (VQIVYK), a short peptide segment found in the microtubule binding region of tau protein…”
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Exploiting Sphingo- and Glycerophospholipid Impairment to Select Effective Drugs and Biomarkers for CMT1A by Visigalli, Davide, Capodivento, Giovanna, Basit, Abdul, Fernández, Roberto, Hamid, Zeeshan, Pencová, Barbora, Gemelli, Chiara, Marubbi, Daniela, Pastorino, Cecilia, Luoma, Adrienne M., Riekel, Christian, Kirschner, Daniel A., Schenone, Angelo, Fernández, José A., Armirotti, Andrea, Nobbio, Lucilla

“…In Charcot-Marie-Tooth type 1A (CMT1A), Schwann cells exhibit a preponderant transcriptional deficiency of genes involved in lipid biosynthesis. This perturbed…”
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Structure of Core Domain of Fibril-Forming PHF/Tau Fragments by Inouye, Hideyo, Sharma, Deepak, Goux, Warren J., Kirschner, Daniel A.

“…Short peptide sequences within the microtubule binding domain of the protein Tau are proposed to be core nucleation sites for formation of amyloid fibrils…”
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Metabolically-incorporated deuterium in myelin localized by neutron diffraction and identified by mass spectrometry by Baumann, Anne, Denninger, Andrew R., Domin, Marek, Demé, Bruno, Kirschner, Daniel A.

“…Myelin is a natural and dynamic multilamellar membrane structure that continues to be of significant biological and neurological interest, especially with…”
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Evolution of a neuroprotective function of central nervous system myelin by Yin, Xinghua, Baek, Rena C, Kirschner, Daniel A, Peterson, Alan, Fujii, Yasuhisa, Nave, Klaus-Armin, Macklin, Wendy B, Trapp, Bruce D

“…The central nervous system (CNS) of terrestrial vertebrates underwent a prominent molecular change when a tetraspan membrane protein, myelin proteolipid…”
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Kinetic Theory of Fibrillogenesis of Amyloid β -protein by Lomakin, Aleksey, Teplow, David B., Kirschner, Daniel A., Benedek, George B.

“…Prior quasielastic light scattering (QLS) studies of fibrillogenesis of synthetic amyloid β -protein (Aβ )-(1-40) at low pH have suggested a kinetic model in…”
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Myelin structure is unaltered in chemotherapy-induced peripheral neuropathy by Gilardini, Alessandra, Avila, Robin L., Oggioni, Norberto, Rodriguez-Menendez, Virginia, Bossi, Mario, Canta, Annalisa, Cavaletti, Guido, Kirschner, Daniel A.

“…► Chemotherapy-induced peripheral neuropathy (CIPN) may affect internodal myelin. ► We examine sciatic nerves in rat models of three commonly used anticancer…”
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Evolution of myelin ultrastructure and the major structural myelin proteins by Inouye, Hideyo, Kirschner, Daniel A

“…Abstract Myelin sheaths, as the specialized tissue wrapping the nerve fibers in the central and peripheral nervous systems (CNS and PNS), are responsible for…”
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Plasmalogen phospholipids protect internodal myelin from oxidative damage by Luoma, Adrienne M., Kuo, Fonghsu, Cakici, Ozgur, Crowther, Michelle N., Denninger, Andrew R., Avila, Robin L., Brites, Pedro, Kirschner, Daniel A.

“…Reactive oxygen species (ROS) are implicated in a range of degenerative conditions, including aging, neurodegenerative diseases, and neurological disorders…”
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Peripheral nervous system plasmalogens regulate Schwann cell differentiation and myelination by da Silva, Tiago Ferreira, Eira, Jessica, Lopes, André T, Malheiro, Ana R, Sousa, Vera, Luoma, Adrienne, Avila, Robin L, Wanders, Ronald J A, Just, Wilhelm W, Kirschner, Daniel A, Sousa, Mónica M, Brites, Pedro

“…Rhizomelic chondrodysplasia punctata (RCDP) is a developmental disorder characterized by hypotonia, cataracts, abnormal ossification, impaired motor…”
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The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles by Snow, Alan D., Castillo, Gerardo M., Nguyen, Beth P., Choi, Paula Y., Cummings, Joel A., Cam, Judy, Hu, Qubai, Lake, Thomas, Pan, Weihong, Kastin, Abba J., Kirschner, Daniel A., Wood, Steven G., Rockenstein, Edward, Masliah, Eliezer, Lorimer, Stephen, Tanzi, Rudolph E., Larsen, Lesley

“…Brain aging and Alzheimer’s disease both demonstrate the accumulation of beta-amyloid protein containing “plaques” and tau protein containing “tangles” that…”
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A Single Intravenous rAAV Injection as Late as P20 Achieves Efficacious and Sustained CNS Gene Therapy in Canavan Mice by Ahmed, Seemin Seher, Li, Huapeng, Cao, Chunyan, Sikoglu, Elif M, Denninger, Andrew R, Su, Qin, Eaton, Samuel, Liso Navarro, Ana A, Xie, Jun, Szucs, Sylvia, Zhang, Hongwei, Moore, Constance, Kirschner, Daniel A, Seyfried, Thomas N, Flotte, Terence R, Matalon, Reuben, Gao, Guangping

“…Canavan’s disease (CD) is a fatal pediatric leukodystrophy caused by mutations in aspartoacylase (AspA) gene. Currently, there is no effective treatment for…”
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A Bacteriophage Capsid Protein Provides a General Amyloid Interaction Motif (GAIM) That Binds and Remodels Misfolded Protein Assemblies by Krishnan, Rajaraman, Tsubery, Haim, Proschitsky, Ming Y., Asp, Eva, Lulu, Michal, Gilead, Sharon, Gartner, Myra, Waltho, Jonathan P., Davis, Peter J., Hounslow, Andrea M., Kirschner, Daniel A., Inouye, Hideyo, Myszka, David G., Wright, Jason, Solomon, Beka, Fisher, Richard A.

“…Misfolded protein aggregates, characterized by a canonical amyloid fold, play a central role in the pathobiology of neurodegenerative diseases. Agents that…”
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Differential effects of Phe19 and Phe20 on fibril formation by amyloidogenic peptide A beta 16-22 (Ac-KLVFFAE-NH2) by Inouye, Hideyo, Gleason, Katherine A, Zhang, Dong, Decatur, Sean M, Kirschner, Daniel A

“…The sequence KLVFFAE (A beta 16-22) in Alzheimer's beta-amyloid is thought to be a core beta-structure that could act as a template for folding other parts of…”
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Differential effects of phe19 and phe20 on fibril formation by amyloidogenic peptide Aβ16-22 (Ac-KLVFFAE-NH2) by Inouye, Hideyo, Gleason, Katherine A., Zhang, Dong, Decatur, Sean M., Kirschner, Daniel A.

“…The sequence KLVFFAE (Aβ16–22) in Alzheimer's β‐amyloid is thought to be a core β‐structure that could act as a template for folding other parts of the…”
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Myelin structure in unfixed, single nerve fibers: Scanning X-ray microdiffraction with a beam size of 200nm by Inouye, Hideyo, Kuo, Fong-Hsu, Denninger, Andrew R., Weinhausen, Britta, Burghammer, Manfred, Kirschner, Daniel A.

“…Previous raster-scanning with a 1μm X-ray beam of individual, myelinated fibers from glutaraldehyde-fixed rat sciatic nerve revealed a spatially-dependent…”
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