Search Results - "Kirsch, Ralph E."

Rodent nutritional model of non-alcoholic steatohepatitis: Species, strain and sex difference studies by KIRSCH, RICHARD, CLARKSON, VIVIAN, SHEPHARD, ENID G, MARAIS, DAVID A, JAFFER, MOHAMED A, WOODBURNE, VIVIENNE E, KIRSCH, RALPH E, HALL, PAULINE DE LA M

“…Background and Aim:  The methionine choline‐deficient (MCD) diet leads to steatohepatitis in rodents. The aim of the present study was to investigate species,…”
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Clinical Recognition of Glaucomatous Cupping by Kirsch, Ralph E., Anderson, Douglas R.

“…[...]available were the patients' clinical records, which contained narrative descriptions and disk diagrams. Since completing the formal study more than a…”
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A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria by Meissner, Peter N, Dailey, Tamara A, Hift, Richard J, Ziman, Mel, Corrigall, Anne V, Roberts, Andrew G, Meissner, Doreen M, Kirsch, Ralph E, Dailey, Harry A

“…Variegate porphyria (VP), a low-penetrant autosomal dominant inherited disorder of haem metabolism, is characterised by photosensitivity (Fig. 1) and a…”
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Kinetic and physical characterisation of recombinant wild-type and mutant human protoporphyrinogen oxidases by Maneli, Mbulelo H., Corrigall, Anne V., Klump, Horst H., Davids, Lester M., Kirsch, Ralph E., Meissner, Peter N.

“…The effects of various protoporphyrinogen oxidase (PPOX) mutations responsible for variegate porphyria (VP), the roles of the arginine-59 residue and the…”
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Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study by Lemmer, Eric R., Vessey, Carina J., Gelderblom, Wentzel C. A., Shephard, Enid G., Van Schalkwyk, Dirk J., Van Wijk, Rochelle A., Marasas, Walter F. O., Kirsch, Ralph E., Hall, Pauline de la M.

“…Fumonisin B1 (FB1) is a naturally occurring mycotoxin produced by Fusarium verticillioides. Dietary exposure to FB1 has been linked to human cancer in certain…”
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Threshold effect of liver iron content on hepatic inflammation and fibrosis in hepatitis B and C by Beinker, Nele K., Voigt, Michael D, Arendse, Michael, Smit, Julian, Stander, Ilse A., Kirsch, Ralph E.

“…Background/Aims: In hepatitis C, iron depletion may improve serum aminotransferases and the response to interferon, but it is not known whether inflammation…”
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Fibrinogen is degraded and internalized during incubation with neutrophils, and fibrinogen products localize to electron lucent vesicles by Kirsch, Richard, Jaffer, Mohamed A, Woodburne, Vivienne E, Sewell, Trevor, Kelly, Sharon L, Kirsch, Ralph E, Shephard, Enid G

“…A biologically relevant relationship exists between neutrophils and coagulation processes. Several studies have focused on the ability of neutrophil proteases…”
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Fibrin and fibrinogen-related antigens in patients with stable and unstable coronary artery disease by Kruskal, J B, Commerford, P J, Franks, J J, Kirsch, R E

“…Coronary-artery thrombosis may be important in the pathogenesis of unstable angina at rest. To study this possibility, we measured the serum concentrations of…”
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Patients with stable uncomplicated cirrhosis have normal neutrophil function by Kirsch, Richard, Woodburne, Vivienne E, Shephard, Enid G, Kirsch, Ralph E

“…Background: Neutrophil function has been reported to be abnormal in patients with cirrhosis. In order to evaluate the relative contribution of hepatocellular…”
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The effects of dietary iron overload on fumonisin B1-induced cancer promotion in the rat liver by Lemmer, Eric R, Gelderblom, Wentzel C.A, Shephard, Enid G, Abel, Stefan, Seymour, Beverley L, Peter Cruse, J, Kirsch, Ralph E, Marasas, Walter F.O, de la M. Hall, Pauline

“…The present study was performed to determine whether excess hepatic iron modulates the cancer-initiating and promoting properties of FB1. Thirty-eight male…”
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Identification and characterisation of a deletion (537delAT) in the protoporphyrinogen oxidase gene in a South African variegate porphyria family by Corrigall, Anne V., Hift, Richard J., Hancock, Valerie, Meissner, Doreen, Davids, Lester, Kirsch, Ralph E., Meissner, Peter N.

“…Variegate porphyria is an autosomal dominant disorder of haem metabolism resulting from a partial decrease in protoporphyrinogen oxidase activity. Variegate…”
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Inhibition of T cell mitogenesis by a novel anti-CD45R monoclonal antibody by Robson, S C, Siegel, J B, Kirsch, R E

“…CD45 consists of a major family of membrane glycoproteins which have protein tyrosine phosphatase activity and regulate early activation events, progression…”
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Catalysis of angiotensin I hydrolysis by human angiotensin-converting enzyme: effect of chloride and pH by Ehlers, Mario R. W, Kirsch, Ralph E

“…The catalysis of the hydrolysis of angiotensin I, an important natural substrate, by human angiotensin-converting enzyme (ACE) was examined in detail as a…”
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Treatment of acute myocardial infarction with streptokinase does not appear to modulate circulating neutrophil function by Adams, S A, Froese, S P, Green, B K, Commerford, P J, Kirsch, R E, Shephard, E G, Robson, S C

“…The administration of thrombolytic therapy is the most common method of achieving patency of the occluded coronary artery in patients with acute myocardial…”
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Evidence that the GBV-C/hepatitis G virus is primarily a lymphotropic virus by Tucker, Timothy J., Smuts, Heidi E.M., Eedes, Christopher, Knobel, Gideon D., Eickhaus, Peter, Robson, Simon C., Kirsch, Ralph E.

“…GB virus‐C and the hepatitis G virus (GBV‐C/HGV) are variants of the same positive sense RNA flavivirus, initially thought to be associated with hepatitis. The…”
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Histopathology and gene expression changes in rat liver during feeding of fumonisin B1, a carcinogenic mycotoxin produced by Fusarium moniliforme by Lemmer, Eric R., de la Motte Hall, Pauline, Omori, Nobuhiko, Omori, Masako, Shephard, Enid G., Gelderblom, Wentzel C.A., Cruse, J. Peter, Barnard, Rochelle A., Marasas, Walter F.O., Kirsch, Ralph E., Thorgeirsson, Snorri S.

“…Fumonisin B1 (FB1) is a carcinogenic mycotoxin produced by the fungus Fusarium moniliforme in corn. Feeding of FB1 to rats causes acute liver injury, chronic…”
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Variegate porphyria by Kirsch, R E, Meissner, P N, Hift, R J

“…Variegate porphyria is an autosomal dominant inherited trait resulting in decreased activity of protoporphyrinogen oxidase. It is characterized clinically by…”
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Isolation from human fetal liver of cells co-expressing CD34 haematopoietic stem cell and CAM 5.2 pancytokeratin markers by Lemmer, Eric R., Shephard, Enid G., Blakolmer, Karin, Kirsch, Ralph E., Robson, Simon C.

“…Background/Aims: Ductal plate and bile duct cells in developing human liver express haemotopoietic stem cell markers, such as c-kit and CD34, in association…”
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The lens by Kirsch, R E

“…The subjects to be reviewed are as follows: (1) Anatomy, histology, and pathology. (2) Genetic and congenital anomalies. (3) Cataract. (Under cataract we shall…”
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Molecular characterization of the 5′ non-coding region of South African GBV-C/HGV isolates: Major deletion and evidence for a fourth genotype by Tucker, Timothy J., Smuts, Heidi, Eickhaus, Peter, Robson, Simon C., Kirsch, Ralph E.

“…GB virus C/hepatitis G virus (GBV‐C/HGV) has been characterised as a novel flavivirus, and to date three known genotypes have been cloned. Greater genetic…”
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