Search Results - "Kirsch, G."

Strategies for optimizing the response of cancer and normal tissues to radiation by Moding, Everett J., Kastan, Michael B., Kirsch, David G.

“…Key Points More than half of all patients with cancer receive radiation therapy. Normal tissue tolerance for radiation limits the dose of radiation that can…”
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Dietary methionine influences therapy in mouse cancer models and alters human metabolism by Gao, Xia, Sanderson, Sydney M., Dai, Ziwei, Reid, Michael A., Cooper, Daniel E., Lu, Min, Richie, John P., Ciccarella, Amy, Calcagnotto, Ana, Mikhael, Peter G., Mentch, Samantha J., Liu, Juan, Ables, Gene, Kirsch, David G., Hsu, David S., Nichenametla, Sailendra N., Locasale, Jason W.

“…Nutrition exerts considerable effects on health, and dietary interventions are commonly used to treat diseases of metabolic aetiology. Although cancer has a…”
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Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database by Nussbaum, Daniel P, MD, Rushing, Christel N, MS, Lane, Whitney O, MD, Cardona, Diana M, MD, Kirsch, David G, Prof, Peterson, Bercedis L, PhD, Blazer, Dan G, MD

“…Summary Background Recruitment into clinical trials for retroperitoneal sarcoma has been challenging, resulting in termination of the only randomised…”
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PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma by Barton, Kelly L, Misuraca, Katherine, Cordero, Francisco, Dobrikova, Elena, Min, Hooney D, Gromeier, Matthias, Kirsch, David G, Becher, Oren J

“…Diffuse intrinsic pontine glioma (DIPG) is an incurable tumor that arises in the brainstem of children. To date there is not a single approved drug to…”
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Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma by Kim, Kyu-Tae, Lee, Hye Won, Lee, Hae-Ock, Song, Hye Jin, Jeong, Da Eun, Shin, Sang, Kim, Hyunho, Shin, Yoojin, Nam, Do-Hyun, Jeong, Byong Chang, Kirsch, David G, Joo, Kyeung Min, Park, Woong-Yang

“…Intratumoral heterogeneity hampers the success of marker-based anticancer treatment because the targeted therapy may eliminate a specific subpopulation of…”
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Bone protection by inhibition of microRNA-182 by Inoue, Kazuki, Deng, Zhonghao, Chen, Yufan, Giannopoulou, Eugenia, Xu, Ren, Gong, Shiaoching, Greenblatt, Matthew B., Mangala, Lingegowda S., Lopez-Berestein, Gabriel, Kirsch, David G., Sood, Anil K., Zhao, Liang, Zhao, Baohong

“…Targeting microRNAs recently shows significant therapeutic promise; however, such progress is underdeveloped in treatment of skeletal diseases with osteolysis,…”
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Neutrophils promote tumor resistance to radiation therapy by Wisdom, Amy J., Hong, Cierra S., Lin, Alexander J., Xiang, Yu, Cooper, Daniel E., Zhang, Jin, Xu, Eric S., Kuo, Hsuan-Cheng, Mowery, Yvonne M., Carpenter, David J., Kadakia, Kushal T., Himes, Jonathon E., Luo, Lixia, Ma, Yan, Williams, Nerissa, Cardona, Diana M., Haldar, Malay, Diao, Yarui, Markovina, Stephanie, Schwarz, Julie K., Kirsch, David G.

“…Nearly two-thirds of cancer patients are treated with radiation therapy (RT), often with the intent to achieve complete and permanent tumor regression (local…”
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Intravital imaging of mouse embryos by Huang, Qiang, Cohen, Malkiel A, Alsina, Fernando C, Devlin, Garth, Garrett, Aliesha, McKey, Jennifer, Havlik, Patrick, Rakhilin, Nikolai, Wang, Ergang, Xiang, Kun, Mathews, Parker, Wang, Lihua, Bock, Cheryl, Ruthig, Victor, Wang, Yi, Negrete, Marcos, Wong, Chi Wut, Murthy, Preetish K L, Zhang, Shupei, Daniel, Andrea R, Kirsch, David G, Kang, Yubin, Capel, Blanche, Asokan, Aravind, Silver, Debra L, Jaenisch, Rudolf, Shen, Xiling

“…Embryonic development is a complex process that is unamenable to direct observation. In this study, we implanted a window to the mouse uterus to visualize the…”
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Dicer1 functions as a haploinsufficient tumor suppressor by Kumar, Madhu S, Pester, Ryan E, Chen, Cindy Y, Lane, Keara, Chin, Christine, Lu, Jun, Kirsch, David G, Golub, Todd R, Jacks, Tyler

“…While the global down-regulation of microRNAs (miRNAs) is a common feature of human tumors, its genetic basis is largely undefined. To explore this question,…”
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Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma by Wisdom, Amy J., Mowery, Yvonne M., Riedel, Richard F., Kirsch, David G.

“…Soft tissue sarcomas (STS) are heterogeneous, mesenchymal malignancies with variable biologic behavior. The primary management for localized STS is surgical…”
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Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study by Ashton, Jeffrey R, Clark, Darin P, Moding, Everett J, Ghaghada, Ketan, Kirsch, David G, West, Jennifer L, Badea, Cristian T

“…To provide additional functional information for tumor characterization, we investigated the use of dual-energy computed tomography for imaging murine lung…”
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Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy by Wisdom, Amy J., Mowery, Yvonne M., Hong, Cierra S., Himes, Jonathon E., Nabet, Barzin Y., Qin, Xiaodi, Zhang, Dadong, Chen, Lan, Fradin, Hélène, Patel, Rutulkumar, Bassil, Alex M., Muise, Eric S., King, Daniel A., Xu, Eric S., Carpenter, David J., Kent, Collin L., Smythe, Kimberly S., Williams, Nerissa T., Luo, Lixia, Ma, Yan, Alizadeh, Ash A., Owzar, Kouros, Diehn, Maximilian, Bradley, Todd, Kirsch, David G.

“…Immunotherapy fails to cure most cancer patients. Preclinical studies indicate that radiotherapy synergizes with immunotherapy, promoting radiation-induced…”
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A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy by Liu, Yang, Ashton, Jeffrey R, Moding, Everett J, Yuan, Hsiangkuo, Register, Janna K, Fales, Andrew M, Choi, Jaeyeon, Whitley, Melodi J, Zhao, Xiaoguang, Qi, Yi, Ma, Yan, Vaidyanathan, Ganesan, Zalutsky, Michael R, Kirsch, David G, Badea, Cristian T, Vo-Dinh, Tuan

“…Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved…”
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Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis by Eisinger-Mathason, T S Karin, Zhang, Minsi, Qiu, Qiong, Skuli, Nicolas, Nakazawa, Michael S, Karakasheva, Tatiana, Mucaj, Vera, Shay, Jessica E S, Stangenberg, Lars, Sadri, Navid, Puré, Ellen, Yoon, Sam S, Kirsch, David G, Simon, M Celeste

“…Intratumoral hypoxia and expression of hypoxia-inducible factor-1α (HIF-1α) correlate with metastasis and poor survival in patients with sarcoma. We show here…”
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Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy by Ashton, Jeffrey R, Castle, Katherine D, Qi, Yi, Kirsch, David G, West, Jennifer L, Badea, Cristian T

“…Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and computed tomography (CT) imaging. AuNPs absorb x-rays and subsequently…”
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Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus by Floyd, Warren, Pierpoint, Matthew, Su, Chang, Patel, Rutulkumar, Luo, Lixia, Deland, Katherine, Wisdom, Amy J, Zhu, Daniel, Ma, Yan, DeWitt, Suzanne Bartholf, Williams, Nerissa T, Lazarides, Alexander L, Somarelli, Jason A, Corcoran, David L, Eward, William C, Cardona, Diana M, Kirsch, David G

“…ATRX is one of the most frequently altered genes in solid tumors, and mutation is especially frequent in soft tissue sarcomas. However, the role of ATRX in…”
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Epidermal growth factor regulates hematopoietic regeneration after radiation injury by Doan, Phuong L, Himburg, Heather A, Helms, Katherine, Russell, J Lauren, Fixsen, Emma, Quarmyne, Mamle, Harris, Jeffrey R, Deoliviera, Divino, Sullivan, Julie M, Chao, Nelson J, Kirsch, David G, Chute, John P

“…John Chute and his colleagues show that the cytokine EGF protects mouse bone marrow hematopoietic stem cells from radiation injury. EGF signaling in these…”
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Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials by Coleman, C Norman, Higgins, Geoff S, Brown, J Martin, Baumann, Michael, Kirsch, David G, Willers, Henning, Prasanna, Pataje G S, Dewhirst, Mark W, Bernhard, Eric J, Ahmed, Mansoor M

“…There is an urgent need to improve reproducibility and translatability of preclinical data to fully exploit opportunities for molecular therapeutics involving…”
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p53 promotes revival stem cells in the regenerating intestine after severe radiation injury by Morral, Clara, Ayyaz, Arshad, Kuo, Hsuan-Cheng, Fink, Mardi, Verginadis, Ioannis I., Daniel, Andrea R., Burner, Danielle N., Driver, Lucy M., Satow, Sloane, Hasapis, Stephanie, Ghinnagow, Reem, Luo, Lixia, Ma, Yan, Attardi, Laura D., Koumenis, Constantinos, Minn, Andy J., Wrana, Jeffrey L., Lee, Chang-Lung, Kirsch, David G.

“…Ionizing radiation induces cell death in the gastrointestinal (GI) epithelium by activating p53. However, p53 also prevents animal lethality caused by…”
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An intravital window to image the colon in real time by Rakhilin, Nikolai, Garrett, Aliesha, Eom, Chi-Yong, Chavez, Katherine Ramos, Small, David M., Daniel, Andrea R., Kaelberer, Melanie M., Mejooli, Menansili A., Huang, Qiang, Ding, Shengli, Kirsch, David G., Bohórquez, Diego V., Nishimura, Nozomi, Barth, Bradley B., Shen, Xiling

“…Intravital microscopy is a powerful technique to observe dynamic processes with single-cell resolution in live animals. No intravital window has been developed…”
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