Search Results - "Kirsanov, Kirill"

Effects of G-Quadruplex-Binding Plant Secondary Metabolites on c-MYC Expression by Zenkov, Roman G., Kirsanov, Kirill I., Ogloblina, Anna M., Vlasova, Olga A., Naberezhnov, Denis S., Karpechenko, Natalia Y., Fetisov, Timur I., Lesovaya, Ekaterina A., Belitsky, Gennady A., Dolinnaya, Nina G., Yakubovskaya, Marianna G.

“…Guanine-rich DNA sequences tending to adopt noncanonical G-quadruplex (G4) structures are over-represented in promoter regions of oncogenes. Ligands…”
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FACT is a sensor of DNA torsional stress in eukaryotic cells by Safina, Alfiya, Cheney, Peter, Pal, Mahadeb, Brodsky, Leonid, Ivanov, Alexander, Kirsanov, Kirill, Lesovaya, Ekaterina, Naberezhnov, Denis, Nesher, Elimelech, Koman, Igor, Wang, Dan, Wang, Jianming, Yakubovskaya, Marianna, Winkler, Duane, Gurova, Katerina

“…Transitions of B-DNA to alternative DNA structures (ADS) can be triggered by negative torsional strain, which occurs during replication and transcription, and…”
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Analysis of Multiple Drug Resistance Mechanism in Different Types of Soft Tissue Sarcomas: Assessment of the Expression of ABC-Transporters, MVP, YB-1, and Analysis of Their Correlation with Chemosensitivity of Cancer Cells by Moiseeva, Natalia I, Laletina, Lidia A, Fetisov, Timur I, Makhmudova, Leyla F, Manikaylo, Angelika E, Fomina, Liliya Y, Burov, Denis A, Lesovaya, Ekaterina A, Bokhyan, Beniamin Y, Zinovieva, Victoria Y, Vilkova, Alice S, Mekheda, Larisa V, Kozlov, Nikolay A, Scherbakov, Alexander M, Kirilin, Evgeny M, Belitsky, Gennady A, Yakubovskaya, Marianna G, Kirsanov, Kirill I

“…Chemotherapy of soft tissue sarcomas (STS) is restricted by low chemosensitivity and multiple drug resistance (MDR). The purpose of our study was the analysis…”
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Synthesis and Anti-Cancer Activity of the Novel Selective Glucocorticoid Receptor Agonists of the Phenylethanolamine Series by Zhidkova, Ekaterina M, Tilova, Leyla R, Fetisov, Timur I, Kirsanov, Kirill I, Kulikov, Evgeny P, Enikeev, Adel D, Budunova, Irina V, Badun, Gennadii A, Chernysheva, Maria G, Shirinian, Valerii Z, Yakubovskaya, Marianna G, Lesovaya, Ekaterina A

“…Glucocorticoids (GCs) are widely used for treating hematological malignancies despite their multiple adverse effects. The biological response to GCs relies on…”
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Synephrine and Its Derivative Compound A: Common and Specific Biological Effects by Dodonova, Svetlana A, Zhidkova, Ekaterina M, Kryukov, Alexey A, Valiev, Timur T, Kirsanov, Kirill I, Kulikov, Evgeny P, Budunova, Irina V, Yakubovskaya, Marianna G, Lesovaya, Ekaterina A

“…This review is focused on synephrine, the principal phytochemical found in bitter orange and other medicinal plants and widely used as a dietary supplement for…”
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Nutritional Sensor REDD1 in Cancer and Inflammation: Friend or Foe? by Zhidkova, Ekaterina M., Lylova, Evgeniya S., Grigoreva, Diana D., Kirsanov, Kirill I., Osipova, Alena V., Kulikov, Evgeny P., Mertsalov, Sergey A., Belitsky, Gennady A., Budunova, Irina, Yakubovskaya, Marianna G., Lesovaya, Ekaterina A.

“…Regulated in Development and DNA Damage Response 1 (REDD1)/DNA Damage-Induced Transcript 4 (DDIT4) is an immediate early response gene activated by different…”
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The long winding road to the safer glucocorticoid receptor (GR) targeting therapies by Lesovaya, Ekaterina A, Chudakova, Daria, Baida, Gleb, Zhidkova, Ekaterina M, Kirsanov, Kirill I, Yakubovskaya, Marianna G, Budunova, Irina V

“…Glucocorticoids (Gcs) are widely used to treat inflammatory diseases and hematological malignancies, and despite the introduction of novel anti-inflammatory…”
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Ru(III) Complexes with Lonidamine-Modified Ligands by Shutkov, Ilya A, Okulova, Yulia N, Tyurin, Vladimir Yu, Sokolova, Elena V, Babkov, Denis A, Spasov, Alexander A, Gracheva, Yulia A, Schmidt, Claudia, Kirsanov, Kirill I, Shtil, Alexander A, Redkozubova, Olga M, Shevtsova, Elena F, Milaeva, Elena R, Ott, Ingo, Nazarov, Alexey A

“…A series of bifunctional Ru(III) complexes with lonidamine-modified ligands (lonidamine is a selective inhibitor of aerobic glycolysis in cancer cells) was…”
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Perspectives of Cell Sensitivity/Resistance Assay in Soft Tissue Sarcomas Chemotherapy by Fetisov, Timur I, Khazanova, Sofya A, Shtompel, Polina A, Trapeznikova, Ekaterina S, Zinovieva, Victoria Y, Marshall, Valeria I, Lovenger, Anastasia A, Rogozhin, Dmitriy V, Anastasia, Tararykova A, Bokhyan, Beniamin Yu, Belitsky, Gennady A, Yakubovskaya, Marianna G, Kirsanov, Kirill I

“…Treatment of highly malignant soft tissue sarcomas (STSs) requires multicomponent therapy including surgery, radiotherapy, and chemotherapy. Despite the…”
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HeLa TI cell-based assay as a new approach to screen for chemicals able to reactivate the expression of epigenetically silenced genes by Maksimova, Varvara, Shalginskikh, Natalya, Vlasova, Olga, Usalka, Olga, Beizer, Anastasia, Bugaeva, Polina, Fedorov, Dmitry, Lizogub, Olga, Lesovaya, Ekaterina, Katz, Richard, Belitsky, Gennady, Kirsanov, Kirill, Yakubovskaya, Marianna

“…Chemicals reactivating epigenetically silenced genes target diverse classes of enzymes, including DNMTs, HDACs, HMTs and BET protein family members. They can…”
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Molecular Mechanisms of Anticancer Activity of N-Glycosides of Indolocarbazoles LCS-1208 and LCS-1269 by Zenkov, Roman G, Vlasova, Olga A, Maksimova, Varvara P, Fetisov, Timur I, Karpechenko, Natalia Y, Ektova, Lidiya V, Eremina, Vera A, Popova, Valeriia G, Usalka, Olga G, Lesovaya, Ekaterina A, Belitsky, Gennady A, Yakubovskaya, Marianna G, Kirsanov, Kirill I

“…Novel indolocarbazole derivatives named LCS were synthesized by our research group. Two of them were selected as the most active anticancer agents in vivo. We…”
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Insights into the Mechanism of Curaxin CBL0137 Epigenetic Activity: The Induction of DNA Demethylation and the Suppression of BET Family Proteins by Maksimova, Varvara, Popova, Valeriia, Prus, Anzhelika, Lylova, Evgeniya, Usalka, Olga, Sagitova, Guzel, Zhidkova, Ekaterina, Makus, Julia, Trapeznikova, Ekaterina, Belitsky, Gennady, Yakubovskaya, Marianna, Kirsanov, Kirill

“…The development of malignant tumors is caused by a complex combination of genetic mutations and epigenetic alterations, the latter of which are induced by…”
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TRAIN (Transcription of Repeats Activates INterferon) in response to chromatin destabilization induced by small molecules in mammalian cells by Leonova, Katerina, Safina, Alfiya, Nesher, Elimelech, Sandlesh, Poorva, Pratt, Rachel, Burkhart, Catherine, Lipchick, Brittany, Gitlin, Ilya, Frangou, Costakis, Koman, Igor, Wang, Jianmin, Kirsanov, Kirill, Yakubovskaya, Marianna G, Gudkov, Andrei V, Gurova, Katerina

“…Cellular responses to the loss of genomic stability are well-established, while how mammalian cells respond to chromatin destabilization is largely unknown. We…”
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Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity by Nichugovskiy, Artemiy, Maksimova, Varvara, Trapeznikova, Ekaterina, Eshtukova-Shcheglova, Elizaveta, Ivanov, Igor, Yakubovskaya, Marianna, Kirsanov, Kirill, Cheshkov, Dmitry, Tron, Gian Cesare, Maslov, Mikhail

“…Natural polyamines (PAs) are involved in the processes of proliferation and differentiation of cancer cells. Lipophilic synthetic polyamines (LPAs) induce the…”
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A Brief Overview of the Paradoxical Role of Glucocorticoids in Breast Cancer by Zhidkova, Ekaterina M, Lylova, Evgeniya S, Savinkova, Alena V, Mertsalov, Sergey A, Kirsanov, Kirill I, Belitsky, Gennady A, Yakubovskaya, Marianna G, Lesovaya, Ekaterina A

“…Glucocorticoids (GCs) are stress hormones that play multiple roles in the regulation of cancer cell differentiation, apoptosis, and proliferation. Some types…”
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High Temperature and Humidity Effect on Biochemical Characteristics of Organically-Grown Parsnip Roots Compared to Garlic Bulbs by Golubkina, Nadezhda, Zayachkovsky, Vladimir, Stepanov, Viktor, Deryagina, Valentina, Rizhova, Nataly, Kirsanov, Kirill, Caruso, Gianluca

“…Functional food with high concentrations of monosaccharides and antioxidants is important for quick replenishment of energy reserves and rehabilitation after…”
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A Novel Approach to Safer Glucocorticoid Receptor-Targeted Anti-lymphoma Therapy via REDD1 (Regulated in Development and DNA Damage 1) Inhibition by Lesovaya, Ekaterina A, Savinkova, Alena V, Morozova, Olga V, Lylova, Evgeniya S, Zhidkova, Ekaterina M, Kulikov, Evgeny P, Kirsanov, Kirill I, Klopot, Anna, Baida, Gleb, Yakubovskaya, Marianna G, Gordon, Leo I, Readhead, Ben, Dudley, Joel T, Budunova, Irina

“…Glucocorticoids are widely used for therapy of hematologic malignancies. Unfortunately, chronic treatment with glucocorticoids commonly leads to adverse…”
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Genetic and Molecular Heterogeneity of Synovial Sarcoma and Associated Challenges in Therapy by Lesovaya, Ekaterina A, Fetisov, Timur I, Bokhyan, Beniamin Yu, Maksimova, Varvara P, Kulikov, Evgeny P, Belitsky, Gennady A, Kirsanov, Kirill I, Yakubovskaya, Marianna G

“…Synovial sarcoma (SS) is one of the most common types of pediatric soft tissue sarcoma (STS) being far less frequent in adults. This STS type is characterized…”
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Soft Tissue Sarcoma Study: Association of Genetic Alterations in the Apoptosis Pathways with Chemoresistance to Doxorubicin by Kirilin, Evgeny M, Fetisov, Timur I, Moiseeva, Natalia I, Lesovaya, Ekaterina A, Laletina, Lidia A, Makhmudova, Leyla F, Manikaylo, Angelika E, Fomina, Liliya Y, Burov, Denis A, Bokhyan, Beniamin Yu, Zinovieva, Victoria Y, Vilkova, Alice S, Mekheda, Larisa V, Kozlov, Nikolay A, Scherbakov, Alexander M, Belitsky, Gennady A, Švedas, Vytas, Kirsanov, Kirill I, Yakubovskaya, Marianna G

“…Soft tissue sarcomas (STS) are heterogeneous cancers with more than 100 histological subtypes, different in molecular alterations, which make its personalized…”
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Toxicological Properties of 7-Methylguanine, and Preliminary Data on its Anticancer Activity by Kirsanov, Kirill, Fetisov, Timur, Antoshina, Elena, Trukhanova, Lubov, Gor’kova, Tatiana, Vlasova, Olga, Khitrovo, Irina, Lesovaya, Ekaterina, Kulbachevskaya, Nataliya, Shcherbakova, Tatiana, Belitsky, Gennady, Yakubovskaya, Marianna, Švedas, Vytas, Nilov, Dmitry

“…7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase…”
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