Search Results - "Kirpichnikov, M"

Prospects of Optogenetic Prosthesis of the Degenerative Retina of the Eye by Ostrovsky, M. A., Kirpichnikov, M. P.

“…The review discusses the prospects of using rhodopsin as an optogenetic tool for prosthetics of degenerative (blind) eye retina and the principles of…”
Get full text

Accumulation of β-Amyloid Leads to a Decrease in Lynx1 and Lypd6B Expression in the Hippocampus and Increased Expression of Proinflammatory Cytokines in the Hippocampus and Blood Serum by Bychkov, M. L., Kirichenko, A. V., Paramonov, A. S., Kirpichnikov, M. P., Lukmanova, E. N.

“…Alzheimer’s disease is a rapidly progressive neurodegenerative disease, the development of which is associated with the accumulation of β-amyloid oligomers,…”
Get full text

Human secreted proteins SLURP‐1 and SLURP‐2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors by Lyukmanova, E N, Bychkov, M L, Sharonov, G V, Efremenko, A V, Shulepko, M A, Kulbatskii, D S, Shenkarev, Z O, Feofanov, A V, Dolgikh, D A, Kirpichnikov, M P

“…Background and Purpose Nicotinic acetylcholine receptors (nAChRs) are a promising target for development of new anticancer therapies. Here we have investigated…”
Get full text

Distinct impact of targeted actin cytoskeleton reorganization on mechanical properties of normal and malignant cells by Efremov, Yu.M., Dokrunova, A.A., Efremenko, A.V., Kirpichnikov, M.P., Shaitan, K.V., Sokolova, O.S.

“…The actin cytoskeleton is substantially modified in cancer cells because of changes in actin-binding protein abundance and functional activity. As a…”
Get full text

Erratum to: Advances in Structural Research Using Electron Microscopy in Russia (Results of the Fourth International Conference RICCEM-2023) by Sokolova, O. S., Stanishneva-Konovalova, T. B., Kirpichnikov, M. P.

“…An Erratum to this paper has been published: https://doi.org/10.3103/S0096392524800022…”
Get full text

Advances in Structural Research Using Electron Microscopy in Russia (Results of the Fourth International Conference RICCEM-2023) by Sokolova, O. S., Stanishneva-Konovalova, T. B., Kirpichnikov, M. P.

“…The IV Russian International Conference on Cryo-Electron Microscopy (RICCEM-2023) was held at the Faculty of Biology of Lomonosov Moscow State University in a…”
Get full text

Application of Polyhydroxyalkanoates in Medicine and the Biological Activity of Natural Poly(3-Hydroxybutyrate) by Bonartsev, A P, Bonartseva, G A, Reshetov, I V, Kirpichnikov, M P, Shaitan, K V

“…Biodegradable and biocompatible polymers, polyhydroxyalkanoates (PHAs), are actively used in medicine to produce a wide range of medical devices and dosage…”
Get full text

Optimization of recombinant antibody production based on the vector design and the level of metabolites for generation of Ig- producing stable cell lines by Toporova, V. A, Argentova, V. V, Aliev, T. K, Panina, A. A, Dolgikh, D. A, Kirpichnikov, M. P

“…Background The biopharmaceutical industry is significantly growing worldwide, and the Chinese hamster ovary (CHO) cells are used as a main expression host for…”
Get full text

Aspartate–Histidine Interaction in the Retinal Schiff Base Counterion of the Light-Driven Proton Pump of Exiguobacterium sibiricum by Balashov, S. P, Petrovskaya, L. E, Lukashev, E. P, Imasheva, E. S, Dioumaev, A. K, Wang, J. M, Sychev, S. V, Dolgikh, D. A, Rubin, A. B, Kirpichnikov, M. P, Lanyi, J. K

“…One of the distinctive features of eubacterial retinal-based proton pumps, proteorhodopsins, xanthorhodopsin, and others, is hydrogen bonding of the key…”
Get full text

Application of the Johnson–Kendall–Roberts model in AFM-based mechanical measurements on cells and gel by Efremov, Yu.M., Bagrov, D.V., Kirpichnikov, M.P., Shaitan, K.V.

“…[Display omitted] •The JKR model was applied for analysis of the AFM force curves with adhesion.•The approach and retraction curves obtained on cells and PA…”
Get full text

Mechanical properties of fibroblasts depend on level of cancer transformation by Efremov, Yu.M., Lomakina, M.E., Bagrov, D.V., Makhnovskiy, P.I., Alexandrova, A.Y., Kirpichnikov, M.P., Shaitan, K.V.

“…Recently, it was revealed that tumor cells are significantly softer than normal cells. Although this phenomenon is well known, it is connected with many…”
Get full text

Recombinant SLURP-1 Inhibits Growth and Migration of U251 MG Glioma by Cell Cycle Arrest and Modulation of MAPK and AKT Signaling Pathways by Shulepko, M. A., Bychkov, M. L., Kirpichnikov, M. P., Lyukmanova, E. N.

“…A recombinant analog of the human SLURP-1 protein, rSLURP-1, effectively inhibits the growth of carcinomas by interaction with the α7-type nicotinic…”
Get full text

Safe Use of Genetic Technologies by Kirpichnikov, M. P., Kudryavtsev, A. M.

“…The prospects and problems of the development of modern genetic technologies are analyzed, and pressing issues of updating the regulatory framework for the…”
Get full text

Nonselective Expression of Short-Wavelength Cone Opsin Improves Learning in Mice with Retinal Degeneration in a Visually Guided Task by Idzhilova, O. S., Kolotova, D. E., Smirnova, G. R., Abonakour, A., Dolgikh, D. A., Petrovskaya, L. E., Kirpichnikov, M. P., Ostrovsky, M. A., Malyshev, A. Yu

“…The study explored the potential of an animal opsin nonselectively expressed in various neuronal elements of the degenerative retina to restore the impaired…”
Get full text

PARP1 Inhibitors: antitumor drug design by Malyuchenko, N V, Kotova, E Yu, Kulaeva, O I, Kirpichnikov, M P, Studitskiy, V M

“…The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear…”
Get full text

Efficient screening of ligand-receptor complex formation using fluorescence labeling and size-exclusion chromatography by Kulbatskii, D.S., Shulepko, M.A., Sluchanko, N.N., Yablokov, E.O., Kamyshinsky, R.A., Chesnokov, Y.M., Kirpichnikov, M.P., Lyukmanova, E.N.

“…Evidence of a complex formation is a crucial step in the structural studies of ligand-receptor interactions. Here we presented a simple and fast approach for…”
Get full text

Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of U251 MG and A172 Glioma Cells by Shulepko, M. A., Bychkov, M. L., Lyukmanova, E. N., Kirpichnikov, M. P.

“…The alpha7 nicotinic acetylcholine receptor (α7-nAChR) is considered a promising pharmacological target for the carcinoma therapy. We have previously shown…”
Get full text

A minimum set of stable blocks for rational design of polypeptide chains by Nekrasov, Alexei N., Alekseeva, Ludmila G., Pogosyan, Rudolf А., Dolgikh, Dmitry A., Kirpichnikov, M.P., de Brevern, Alexandre G., Anashkina, Anastasia A.

“…The aim of this work was to find a minimal set of structurally stable pentapeptides, which allows forming a polypeptide chain of a required 3D structure. To…”
Get full text

A New Efficient Method for Production of Recombinant Antitumor Cytokine TRAIL and Its Receptor-Selective Variant DR5-B by Yagolovich, A. V., Artykov, A. A., Dolgikh, D. A., Kirpichnikov, M. P., Gasparian, M. E.

“…The cytokine TRAIL induces apoptosis in tumor cells of various origin without affecting normal cells. Clinical trials of TRAIL-receptor (DR4 and DR5) agonists…”
Get full text

CombLabel: rational design of optimized sequence-specific combinatorial labeling schemes. Application to backbone assignment of membrane proteins with low stability by Myshkin, M. Yu, Dubinnyi, M. A., Kulbatskii, D. S., Lyukmanova, E. N., Kirpichnikov, M. P., Shenkarev, Z. O.

“…Assignment of backbone resonances is a necessary initial step in every protein NMR investigation. Standard assignment procedure is based on the set of 3D…”
Get full text