Search Results - "Kirpich, A."

Real-time forecasts of the COVID-19 epidemic in China from February 5th to February 24th, 2020 by Roosa, K., Lee, Y., Luo, R., Kirpich, A., Rothenberg, R., Hyman, J.M., Yan, P., Chowell, G.

“…The initial cluster of severe pneumonia cases that triggered the COVID-19 epidemic was identified in Wuhan, China in December 2019. While early cases of the…”
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Gut–liver axis, nutrition, and non-alcoholic fatty liver disease by Kirpich, Irina A., Marsano, Luis S., McClain, Craig J.

“…Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases involving hepatic fat accumulation, inflammation with the potential progression to…”
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Oxidized linoleic acid metabolites induce liver mitochondrial dysfunction, apoptosis, and NLRP3 activation in mice by Schuster, Susanne, Johnson, Casey D., Hennebelle, Marie, Holtmann, Theresa, Taha, Ameer Y., Kirpich, Irina A., Eguchi, Akiko, Ramsden, Christopher E., Papouchado, Bettina G., McClain, Craig J., Feldstein, Ariel E.

“…Circulating oxidized linoleic acid (LA) metabolites (OXLAMs) are increased in patients with nonalcoholic steatohepatitis (NASH) and their levels correlate with…”
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Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease by Kirpich, Irina A, Petrosino, Joseph, Ajami, Nadim, Feng, Wenke, Wang, Yuhua, Liu, Yanlong, Beier, Juliane I, Barve, Shirish S, Yin, Xinmin, Wei, Xiaoli, Zhang, Xiang, McClain, Craig J

“…Alcoholic liver disease (ALD) ranks among major causes of morbidity and mortality. Diet and crosstalk between the gut and liver are important determinants of…”
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Decreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury by Warner, Dennis R., Warner, Jeffrey B., Hardesty, Josiah E., Song, Ying L., King, Taylor N., Kang, Jing X., Chen, Chih-Yu, Xie, Shanfu, Yuan, Fang, Prodhan, Md Aminul Islam, Ma, Xipeng, Zhang, Xiang, Rouchka, Eric C., Maddipati, Krishna Rao, Whitlock, Joan, Li, Eric C., Wang, Gary P., McClain, Craig J., Kirpich, Irina A.

“…Ethanol (EtOH)-induced alterations in intestinal homeostasis lead to multi-system pathologies, including liver injury. ω-6 PUFAs exert pro-inflammatory…”
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Rodent Models of Alcoholic Liver Disease: Role of Binge Ethanol Administration by Ghosh Dastidar, Shubha, Warner, Jeffrey B, Warner, Dennis R, McClain, Craig J, Kirpich, Irina A

“…Both chronic and acute (binge) alcohol drinking are important health and economic concerns worldwide and prominent risk factors for the development of…”
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Hepatic Proteomic Changes Associated with Liver Injury Caused by Alcohol Consumption in Fpr2 - / - Mice by Hardesty, Josiah E, Warner, Jeffrey B, Wilkey, Daniel W, Phinney, Brett S, Salemi, Michelle R, Merchant, Michael L, McClain, Craig J, Warner, Dennis R, Kirpich, Irina A

“…Alcohol-associated liver disease (ALD) is a prevalent medical problem with limited effective treatment strategies. Although many biological processes…”
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The Type of Dietary Fat Modulates Intestinal Tight Junction Integrity, Gut Permeability, and Hepatic Toll-Like Receptor Expression in a Mouse Model of Alcoholic Liver Disease by Kirpich, Irina A., Feng, Wenke, Wang, Yuhua, Liu, Yanlong, Barker, David F., Barve, Shirish S., McClain, Craig J.

“…Background:  Interactions between the gut, immune system, and the liver, as well as the type of fat in the diet, are critical components of alcoholic liver…”
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Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study by Kirpich, Irina A, Solovieva, Natalia V, Leikhter, Svetlana N, Shidakova, Natalia A, Lebedeva, Oxsana V, Sidorov, Pavel I, Bazhukova, Tatjana A, Soloviev, Andrej G, Barve, Shirish S, McClain, Craig J, Cave, Matt

“…Abstract The effects of chronic alcohol consumption on the bowel flora and the potential therapeutic role of probiotics in alcohol-induced liver injury have…”
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Effects of diets enriched in linoleic acid and its peroxidation products on brain fatty acids, oxylipins, and aldehydes in mice by Ramsden, Christopher E., Hennebelle, Marie, Schuster, Susanne, Keyes, Gregory S., Johnson, Casey D., Kirpich, Irina A., Dahlen, Jeff E., Horowitz, Mark S., Zamora, Daisy, Feldstein, Ariel E., McClain, Craig J., Muhlhausler, Beverly S., Makrides, Maria, Gibson, Robert A., Taha, Ameer Y.

“…Linoleic acid (LA) is abundant in modern industrialized diets. Oxidized LA metabolites (OXLAMs) and reactive aldehydes, such as 4-hydroxy-2-nonenal (4-HNE),…”
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Ethanol and unsaturated dietary fat induce unique patterns of hepatic ω-6 and ω-3 PUFA oxylipins in a mouse model of alcoholic liver disease by Warner, Dennis R, Liu, Huilin, Ghosh Dastidar, Shubha, Warner, Jeffrey B, Prodhan, Md Aminul Islam, Yin, Xinmin, Zhang, Xiang, Feldstein, Ariel E, Gao, Bin, Prough, Russell A, McClain, Craig J, Kirpich, Irina A

“…Alcoholic liver disease (ALD), a significant health problem, progresses through the course of several pathologies including steatosis, steatohepatitis,…”
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Ileum Gene Expression in Response to Acute Systemic Inflammation in Mice Chronically Fed Ethanol: Beneficial Effects of Elevated Tissue n-3 PUFAs by Hardesty, Josiah E, Warner, Jeffrey B, Song, Ying L, Rouchka, Eric C, McClain, Craig J, Warner, Dennis R, Kirpich, Irina A

“…Chronic alcohol consumption leads to disturbances in intestinal function which can be exacerbated by inflammation and modulated by different factors, e.g.,…”
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Fpr2 -/- Mice Developed Exacerbated Alcohol-Associated Liver Disease by Hardesty, Josiah E, Warner, Jeffrey B, Song, Ying L, Floyd, Alison, McClain, Craig J, Warner, Dennis R, Kirpich, Irina A

“…Alcohol-associated liver disease (ALD) is the most common chronic liver disease and carries a significant healthcare burden. ALD has no long-term treatment…”
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Human Beta Defensin 2 Ameliorated Alcohol-Associated Liver Disease in Mice by Warner, Jeffrey B, Larsen, Ida S, Hardesty, Josiah E, Song, Ying L, Warner, Dennis R, McClain, Craig J, Sun, Rui, Deng, Zhongbin, Jensen, Benjamin A H, Kirpich, Irina A

“…Alcohol-associated liver disease (ALD) is a prevalent liver disorder and significant global healthcare burden with limited effective therapeutic options. The…”
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Polychlorinated biphenyls altered gut microbiome in CAR and PXR knockout mice exhibiting toxicant-associated steatohepatitis by Wahlang, Banrida, Alexander, Nicholas C., Li, Xiaohong, Rouchka, Eric C., Kirpich, Irina A., Cave, Matthew C.

“…[Display omitted] •Aroclor1260 worsened diet-induced steatohepatitis in CAR and PXR knockout mice.•CAR and PXR ablation increased gut microbiome diversity and…”
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Improved experimental data processing for UHPLC–HRMS/MS lipidomics applied to nonalcoholic fatty liver disease by Patterson, R. E., Kirpich, A. S., Koelmel, J. P., Kalavalapalli, S., Morse, A. M., Cusi, K., Sunny, N. E., McIntyre, L. M., Garrett, T. J., Yost, R. A.

“…Introduction Untargeted metabolomics workflows include numerous points where variance and systematic errors can be introduced. Due to the diversity of the…”
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Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury by Osna, Natalia A, Carter, Wayne G, Ganesan, Murali, Kirpich, Irina A, McClain, Craig J, Petersen, Dennis R, Shearn, Colin T, Tomasi, Maria L, Kharbanda, Kusum K

“…It is likely that the majority of proteins will undergo post-translational modification, be it enzymatic or non-enzymatic. These modified protein(s) regulate…”
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Alcoholic Liver Disease: Update on the Role of Dietary Fat by Kirpich, Irina A, Miller, Matthew E, Cave, Matthew C, Joshi-Barve, Swati, McClain, Craig J

“…Alcoholic liver disease (ALD) spans a spectrum of liver pathology, including fatty liver, alcoholic steatohepatitis, and cirrhosis. Accumulating evidence…”
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Linoleic Acid‐Derived Oxylipins Differentiate Early Stage Alcoholic Hepatitis From Mild Alcohol‐Associated Liver Injury by Warner, Dennis, Vatsalya, Vatsalya, Zirnheld, Kara H., Warner, Jeffrey B., Hardesty, Josiah E., Umhau, John C., McClain, Craig J., Maddipati, Krishnarao, Kirpich, Irina A.

“…Alcohol‐associated liver disease (ALD) is a spectrum of liver disorders ranging from steatosis to steatohepatitis, fibrosis, and cirrhosis. Alcohol‐associated…”
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Alcoholic and non-alcoholic steatohepatitis by Neuman, Manuela G., French, Samuel W., French, Barbara A., Seitz, Helmut K., Cohen, Lawrence B., Mueller, Sebastian, Osna, Natalia A., Kharbanda, Kusum K., Seth, Devanshi, Bautista, Abraham, Thompson, Kyle J., McKillop, Iain H., Kirpich, Irina A., McClain, Craig J., Bataller, Ramon, Nanau, Radu M., Voiculescu, Mihai, Opris, Mihai, Shen, Hong, Tillman, Brittany, Li, Jun, Liu, Hui, Thomes, Paul G., Ganesan, Murali, Malnick, Steve

“…This paper is based upon the “Charles Lieber Satellite Symposia” organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings,…”
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