Search Results - "Kirov, A. S."

Dendritic spines disappear with chilling but proliferate excessively upon rewarming of mature hippocampus by Kirov, S.A, Petrak, L.J, Fiala, J.C, Harris, K.M

“…More dendritic spine synapses occur on mature neurons in hippocampal slices by 2 h of incubation in vitro, than in perfusion-fixed hippocampus. What conditions…”
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Dense core vesicles resemble active-zone transport vesicles and are diminished following synaptogenesis in mature hippocampal slices by Sorra, K.E., Mishra, A., Kirov, S.A., Harris, K.M.

“…Large dense core vesicles (∼100 nm) contain neuroactive peptides and other co-transmitters. Smaller dense core vesicles (∼80 nm) are known to contain…”
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Recurrent spontaneous spreading depolarizations facilitate acute dendritic injury in the ischemic penumbra by Risher, W Christopher, Ard, Deborah, Yuan, Jianghe, Kirov, Sergei A

“…Spontaneous spreading depolarizations (SDs) occur in the penumbra surrounding ischemic core. These SDs, often referred to as peri-infarct depolarizations,…”
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Specific regulation of NRG1 isoform expression by neuronal activity by Liu, Xihui, Bates, Ryan, Yin, Dong-Min, Shen, Chengyong, Wang, Fay, Su, Nan, Kirov, Sergei A, Luo, Yuling, Wang, Jian-Zhi, Xiong, Wen-Cheng, Mei, Lin

“…Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms…”
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Plastic scintillator response to low-energy photons by Williamson, J F, Dempsey, J F, Kirov, A S, Monroe, J I, Binns, W R, Hedtjärn, H

“…The plastic scintillator (PS) is a promising dosimeter for brachytherapy and other low-energy photon applications because of its high sensitivity and…”
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Partial volume effect correction in PET using regularized iterative deconvolution with variance control based on local topology by Kirov, A S, Piao, J Z, Schmidtlein, C R

“…Correcting positron emission tomography (PET) images for the partial volume effect (PVE) due to the limited resolution of PET has been a long-standing…”
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Retrograde signalling in depolarization-induced suppression of inhibition in rat hippocampal CA1 cells by Alger, B E, Pitler, T A, Wagner, J J, Martin, L A, Morishita, W, Kirov, S A, Lenz, R A

“…1. We have investigated the phenomenon of 'depolarization-induced suppression of inhibition' (DSI) using whole-cell voltage-clamp techniques in Ca1 pyramidal…”
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KRAS mutation effects on the 2-[18F]FDG PET uptake of colorectal adenocarcinoma metastases in the liver by Popovic, M., Talarico, O., van den Hoff, J., Kunin, H., Zhang, Z., Lafontaine, D., Dogan, S., Leung, J., Kaye, E., Czmielewski, C., Mayerhoefer, M. E., Zanzonico, P., Yaeger, R., Schöder, H., Humm, J. L., Solomon, S. B., Sofocleous, C. T., Kirov, A. S.

“…Background Deriving individual tumor genomic characteristics from patient imaging analysis is desirable. We explore the predictive value of 2-[18F]FDG uptake…”
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GeneKeyDB: a lightweight, gene-centric, relational database to support data mining environments by Kirov, S A, Peng, X, Baker, E, Schmoyer, D, Zhang, B, Snoddy, J

“…The analysis of biological data is greatly enhanced by existing or emerging databases. Most existing databases, with few exceptions are not designed to easily…”
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Using an external gating signal to estimate noise in PET with an emphasis on tracer avid tumors by Schmidtlein, C R, Beattie, B J, Bailey, D L, Akhurst, T J, Wang, W, Gönen, M, Kirov, A S, Humm, J L

“…The purpose of this study is to establish and validate a methodology for estimating the standard deviation of voxels with large activity concentrations within…”
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New water equivalent liquid scintillation solutions for 3D dosimetry by Kirov, A. S., Shrinivas, S., Hurlbut, C., Dempsey, J. F., Binns, W. R., Poblete, J. L.

“…Despite recent advances in radiochromic film and gel dosimetry techniques, radiation therapy still lacks an efficient, accurate, and convenient dose…”
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Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated by Harris, Kristen M, Kirov, Sergei A

“…Dendrites of CA1 pyramidal neurons in mature rat hippocampal slices were exposed to different levels of synaptic activation. In some slices, synaptic…”
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Experimental validation of Monte Carlo dose calculations about a high-intensity Ir-192 source for pulsed dose-rate brachytherapy by Valicenti, R K, Kirov, A S, Meigooni, A S, Mishra, V, Das, R K, Williamson, J F

“…Despite widespread use of high-intensity Ir-192 remotely afterloaded sources, no published measured or calculated dose-rate tables for currently used source…”
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Slices Have More Synapses than Perfusion-Fixed Hippocampus from both Young and Mature Rats by Kirov, Sergei A, Sorra, Karin E, Harris, Kristen M

“…Hippocampal slices have long been used to investigate properties of synaptic transmission and plasticity. Here, for the first time, synapses in slices have…”
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SU‐D‐110‐03: A New Phantom Allowing Realistic Non‐Uniform Activity Distributions for PET Quantification by Kirov, A S, Sculley, E, Schmidtlein, C R, Siman, W, Kandel, B, Zdenek, R, Schwar, R, Ayzenberg, G, Yorke, E, Schöder, H, Humm, J L, Amols, H I

“…Purpose: To develop and test the design of a new phantom, which is capable of producing experimental models of realistic activity distributions as observed in…”
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GATE: a simulation toolkit for PET and SPECT by Jan, S, Santin, G, Strul, D, Staelens, S, Assié, K, Autret, D, Avner, S, Barbier, R, Bardiès, M, Bloomfield, P M, Brasse, D, Breton, V, Bruyndonckx, P, Buvat, I, Chatziioannou, A F, Choi, Y, Chung, Y H, Comtat, C, Donnarieix, D, Ferrer, L, Glick, S J, Groiselle, C J, Guez, D, Honore, P F, Kerhoas-Cavata, S, Kirov, A S, Kohli, V, Koole, M, Krieguer, M, van der Laan, D J, Lamare, F, Largeron, G, Lartizien, C, Lazaro, D, Maas, M C, Maigne, L, Mayet, F, Melot, F, Merheb, C, Pennacchio, E, Perez, J, Pietrzyk, U, Rannou, F R, Rey, M, Schaart, D R, Schmidtlein, C R, Simon, L, Song, T Y, Vieira, J M, Visvikis, D, Van de Walle, R, Wieërs, E, Morel, C

“…Monte Carlo simulation is an essential tool in emission tomography that can assist in the design of new medical imaging devices, the optimization of…”
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Towards two-dimensional brachytherapy dosimetry using plastic scintillator: New highly efficient water equivalent plastic scintillator materials by Kirov, A. S., Hurlbut, C., Dempsey, J. F., Shrinivas, S. B., Epstein, J. W., Binns, W. R., Dowkontt, P. F., Williamson, J. F.

“…Plastic scintillator (PS) has been proposed for both one- and two-dimensional (1D and 2D) dose measurements for radiation therapy applications. For low-energy…”
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Measurement and calculation of heterogeneity correction factors for an Ir-192 high dose-rate brachytherapy source behind tungsten alloy and steel shields by Kirov, A S, Williamson, J F, Meigooni, A S, Zhu, Y

“…Shields made of high atomic number material are commonly used in vaginal applicators with high dose-rate (HDR) 192Ir remotely afterloaded brachytherapy…”
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Two-dimensional scatter integration method for brachytherapy dose calculations in 3D geometry by Kirov, A S, Williamson, J F

“…In brachytherapy clinical practice, applicator shielding and tissue heterogeneities are usually not explicitly taken into account. None of the existing dose…”
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TU‐B‐BRC‐01: Promise and Challenges of PET for Target Definition and Treatment Response Evaluation by Jeraj, R, Kirov, AS

“…Positron Emission Tomography (PET) images show physiological and biological information through the in vivo distribution of radioactive, positron‐emitting…”
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