Search Results - "Kirkwood, Alfredo"

Mechanisms of Homeostatic Synaptic Plasticity in vivo by Lee, Hey-Kyoung, Kirkwood, Alfredo

“…Synapses undergo rapid activity-dependent plasticity to store information, which when left uncompensated can lead to destabilization of neural function. It has…”
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Light Affects Mood and Learning through Distinct Retina-Brain Pathways by Fernandez, Diego Carlos, Fogerson, P. Michelle, Lazzerini Ospri, Lorenzo, Thomsen, Michael B., Layne, Robert M., Severin, Daniel, Zhan, Jesse, Singer, Joshua H., Kirkwood, Alfredo, Zhao, Haiqing, Berson, David M., Hattar, Samer

“…Light exerts a range of powerful biological effects beyond image vision, including mood and learning regulation. While the source of photic information…”
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Self-organized criticality occurs in non-conservative neuronal networks during 'up' states by Niebur, Ernst, Millman, Daniel, Mihalas, Stefan, Kirkwood, Alfredo

“…During sleep, under anaesthesia and in vitro, cortical neurons in sensory, motor, association and executive areas fluctuate between so-called up and down…”
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Aberrant light directly impairs mood and learning through melanopsin-expressing neurons by LeGates, Tara A., Altimus, Cara M., Wang, Hui, Lee, Hey-Kyoung, Yang, Sunggu, Zhao, Haiqing, Kirkwood, Alfredo, Weber, E. Todd, Hattar, Samer

“…Mice subjected to an aberrant daily light cycle that still maintain the circadian timing system are shown to exhibit increased depression-like behaviours and…”
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Distinct Eligibility Traces for LTP and LTD in Cortical Synapses by He, Kaiwen, Huertas, Marco, Hong, Su Z., Tie, XiaoXiu, Hell, Johannes W., Shouval, Harel, Kirkwood, Alfredo

“…In reward-based learning, synaptic modifications depend on a brief stimulus and a temporally delayed reward, which poses the question of how synaptic activity…”
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Endocannabinoid Signaling Contributes to Experience-Induced Increase of Synaptic Release Sites From Parvalbumin Interneurons in Mouse Visual Cortex by Huang, Shiyong, Kirkwood, Alfredo

“…During postnatal development of visual cortex between eye-opening to puberty, visual experience promotes gradually increase in the strength of inhibitory…”
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Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits by Bridi, Michelle C.D., Zong, Fang-Jiao, Min, Xia, Luo, Nancy, Tran, Trinh, Qiu, Jiaqian, Severin, Daniel, Zhang, Xue-Ting, Wang, Guanglin, Zhu, Zheng-Jiang, He, Kai-Wen, Kirkwood, Alfredo

“…A balance between synaptic excitation and inhibition (E/I balance) maintained within a narrow window is widely regarded to be crucial for cortical processing…”
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Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period by Gu, Yu, Tran, Trinh, Murase, Sachiko, Borrell, Andrew, Kirkwood, Alfredo, Quinlan, Elizabeth M

“…Maturation of excitatory drive onto fast-spiking interneurons (FS INs) in the visual cortex has been implicated in the control of the timing of the critical…”
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AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex by Lee, Hey-Kyoung, Kirkwood, Alfredo

“…► Many forms of synaptic plasticity depend on AMPAR regulation. ► Different forms of synaptic plasticity often tap into similar mechanisms of AMPAR regulation…”
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Daily oscillations of neuronal membrane capacitance by Severin, Daniel, Moreno, Cristián, Tran, Trinh, Wesselborg, Christian, Shirley, Sofia, Contreras, Altagracia, Kirkwood, Alfredo, Golowasch, Jorge

“…Capacitance of biological membranes is determined by the properties of the lipid portion of the membrane as well as the morphological features of a cell. In…”
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Norepinephrine potentiates and serotonin depresses visual cortical responses by transforming eligibility traces by Hong, Su Z., Mesik, Lukas, Grossman, Cooper D., Cohen, Jeremiah Y., Lee, Boram, Severin, Daniel, Lee, Hey-Kyoung, Hell, Johannes W., Kirkwood, Alfredo

“…Reinforcement allows organisms to learn which stimuli predict subsequent biological relevance. Hebbian mechanisms of synaptic plasticity are insufficient to…”
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Metabotropic Glutamate Receptors Induce a Form of LTP Controlled by Translation and Arc Signaling in the Hippocampus by Wang, Hui, Ardiles, Alvaro O, Yang, Sunggu, Tran, Trinh, Posada-Duque, Rafael, Valdivia, Gonzalo, Baek, Min, Chuang, Yang-An, Palacios, Adrian G, Gallagher, Michela, Worley, Paul, Kirkwood, Alfredo

“…Activity-dependent bidirectional modifications of excitatory synaptic strength are essential for learning and storage on new memories. Research on…”
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The Maturation of GABAergic Transmission in Visual Cortex Requires Endocannabinoid-Mediated LTD of Inhibitory Inputs during a Critical Period by Jiang, Bin, Huang, Shiyong, de Pasquale, Roberto, Millman, Daniel, Song, Lihua, Lee, Hey-Kyoung, Tsumoto, Tadaharu, Kirkwood, Alfredo

“…Endocannabinoids are widely regarded as negative modulators of presynaptic release. Here, we present evidence that in visual cortex endocannabinoids are…”
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Obligatory Role for the Immediate Early Gene NARP in Critical Period Plasticity by Gu, Yu, Huang, Shiyong, Chang, Michael C., Worley, Paul, Kirkwood, Alfredo, Quinlan, Elizabeth M.

“…The immediate early gene neuronal activity-regulated pentraxin (NARP) is an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) binding…”
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Neuromodulators Control the Polarity of Spike-Timing-Dependent Synaptic Plasticity by Seol, Geun Hee, Ziburkus, Jokubas, Huang, ShiYong, Song, Lihua, Kim, In Tae, Takamiya, Kogo, Huganir, Richard L., Lee, Hey-Kyoung, Kirkwood, Alfredo

“…Near coincidental pre- and postsynaptic action potentials induce associative long-term potentiation (LTP) or long-term depression (LTD), depending on the order…”
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Postsynaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer’s disease by Ardiles, Álvaro O, Tapia-Rojas, Cheril C, Mandal, Madhuchhanda, Alexandre, Frédéric, Kirkwood, Alfredo, Inestrosa, Nibaldo C, Palacios, Adrian G

“…Alzheimer’s disease (AD) is an age-related neurodegenerative disorder associated with progressive memory loss, severe dementia, and hallmark neuropathological…”
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Editorial: Insights in synaptic neuroscience 2022 by Lamsa, Karri P, Kirkwood, Alfredo, Sjöström, P Jesper

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Two distinct mechanisms for experience-dependent homeostasis by Bridi, Michelle C. D., de Pasquale, Roberto, Lantz, Crystal L., Gu, Yu, Borrell, Andrew, Choi, Se-Young, He, Kaiwen, Tran, Trinh, Hong, Su Z., Dykman, Andrew, Lee, Hey-Kyoung, Quinlan, Elizabeth M., Kirkwood, Alfredo

“…Models of firing rate homeostasis such as synaptic scaling and the sliding synaptic plasticity modification threshold predict that decreasing neuronal activity…”
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Sequential Development of Long-Term Potentiation and Depression in Different Layers of the Mouse Visual Cortex by Jiang, Bin, Trevino, Mario, Kirkwood, Alfredo

“…Visual deprivation affects the responses of layer IV cells more prominently during early postnatal development, whereas responses in layer II/III remain…”
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Potential Adaptive Function for Altered Long-Term Potentiation Mechanisms in Aging Hippocampus by Boric, Katica, Munoz, Pablo, Gallagher, Michela, Kirkwood, Alfredo

“…Age-dependent alterations in the induction of long-term potentiation (LTP) are well documented, providing a likely neural basis for memory decline associated…”
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