Search Results - "Kirkland, James L"

Cellular Senescence: A Translational Perspective by Kirkland, James L., Tchkonia, Tamara

“…Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory,…”
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Aging and adipose tissue: potential interventions for diabetes and regenerative medicine by Palmer, Allyson K., Kirkland, James L.

“…Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral insulin resistance, ectopic lipid deposition, and inflammation…”
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Tumor dormancy and disease recurrence by Kirkland, James L.

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The Clinical Potential of Senolytic Drugs by Kirkland, James L., Tchkonia, Tamara, Zhu, Yi, Niedernhofer, Laura J., Robbins, Paul D.

“…Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in…”
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function by Larsson, Lars, Degens, Hans, Li, Meishan, Salviati, Leonardo, Lee, Young Il, Thompson, Wesley, Kirkland, James L, Sandri, Marco

“…Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility, diminishes quality of life, and can lead to fall-related injuries, which…”
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Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions by Tripathi, Utkarsh, Misra, Avanish, Tchkonia, Tamar, Kirkland, James L.

“…•Cellular senescence is a dynamic process and appears to be a heterogenous cell fate.•We hypothesize that senescent cells can be of helper (H) or deleterious…”
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New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms by Tchkonia, Tamar, Palmer, Allyson K, Kirkland, James L

“…Abstract The elderly population is increasing faster than other segments of the population throughout the world. Age is the leading predictor for most chronic…”
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Mechanisms and Metabolic Implications of Regional Differences among Fat Depots by Tchkonia, Tamara, Thomou, Thomas, Zhu, Yi, Karagiannides, Iordanes, Pothoulakis, Charalabos, Jensen, Michael D., Kirkland, James L.

“…Fat distribution is closely linked to metabolic disease risk. Distribution varies with sex, genetic background, disease state, certain drugs and hormones,…”
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Discovery, development, and future application of senolytics: theories and predictions by Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamar, Kirkland, James L.

“…Senescent cells accumulate with aging and at etiological sites of multiple diseases, including those accounting for most morbidity, mortality, and health…”
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Inhibiting Cellular Senescence: A New Therapeutic Paradigm for Age-Related Osteoporosis by Khosla, Sundeep, Farr, Joshua N, Kirkland, James L

“…Abstract Context With the aging of the population and projected increase in osteoporotic fractures coupled with the declining use of osteoporosis medications,…”
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Senescence and apoptosis: dueling or complementary cell fates? by Childs, Bennett G, Baker, Darren J, Kirkland, James L, Campisi, Judith, van Deursen, Jan M

“…In response to a variety of stresses, mammalian cells undergo a persistent proliferative arrest known as cellular senescence. Many senescence‐inducing…”
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Cell senescence, the senescence-associated secretory phenotype, and cancers by Langhi Prata, Larissa G P, Tchkonia, Tamar, Kirkland, James L

“…Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can…”
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty by Stout, Michael B, Justice, Jamie N, Nicklas, Barbara J, Kirkland, James L

“…Advancing age is associated with progressive declines in physiological function that lead to overt chronic disease, frailty, and eventual mortality…”
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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues by Saul, Dominik, Kosinsky, Robyn Laura, Atkinson, Elizabeth J., Doolittle, Madison L., Zhang, Xu, LeBrasseur, Nathan K., Pignolo, Robert J., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Jurk, Diana, Passos, João F., Hickson, LaTonya J., Xue, Ailing, Monroe, David G., Tchkonia, Tamara, Kirkland, James L., Farr, Joshua N., Khosla, Sundeep

“…Although cellular senescence drives multiple age-related co-morbidities through the senescence-associated secretory phenotype, in vivo senescent cell…”
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Identification of HSP90 inhibitors as a novel class of senolytics by Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, McGowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.

“…Aging is the main risk factor for many chronic degenerative diseases and cancer. Increased senescent cell burden in various tissues is a major contributor to…”
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Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity by Palmer, Allyson K, Tchkonia, Tamara, LeBrasseur, Nathan K, Chini, Eduardo N, Xu, Ming, Kirkland, James L

“…Cellular senescence is a fundamental aging mechanism that has been implicated in many age-related diseases and is a significant cause of tissue dysfunction…”
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Senolytics improve physical function and increase lifespan in old age by Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.

“…Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction,…”
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Cellular senescence mediates fibrotic pulmonary disease by Schafer, Marissa J., White, Thomas A., Iijima, Koji, Haak, Andrew J., Ligresti, Giovanni, Atkinson, Elizabeth J., Oberg, Ann L., Birch, Jodie, Salmonowicz, Hanna, Zhu, Yi, Mazula, Daniel L., Brooks, Robert W., Fuhrmann-Stroissnigg, Heike, Pirtskhalava, Tamar, Prakash, Y. S., Tchkonia, Tamara, Robbins, Paul D., Aubry, Marie Christine, Passos, João F., Kirkland, James L., Tschumperlin, Daniel J., Kita, Hirohito, LeBrasseur, Nathan K.

“…Idiopathic pulmonary fibrosis (IPF) is a fatal disease characterized by interstitial remodelling, leading to compromised lung function. Cellular senescence…”
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study by Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.

“…Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis…”
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