Search Results - "Kirkland, J. L."

Senolytic drugs: from discovery to translation by Kirkland, J. L., Tchkonia, T.

“…Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were…”
Get full text

Muscle‐specific differences in expression and phosphorylation of the Janus kinase 2/Signal Transducer and Activator of Transcription 3 following long‐term mechanical ventilation and immobilization in rats by Salah, H., Fury, W., Gromada, J., Bai, Y., Tchkonia, T., Kirkland, J. L., Larsson, L.

“…Aim Muscle wasting is one of the factors most strongly predicting mortality and morbidity in critically ill intensive care unit (ICU). This muscle wasting…”
Get full text

Proceedings of the Canadian Frailty Network Workshop: Identifying Biomarkers of Frailty to Support Frailty Risk Assessment, Diagnosis and Prognosis. Toronto, January 15, 2018 by Muscedere, J, Kim, P M, Afilalo, J, Balion, C, Baracos, V E, Bowdish, D, Cesari, M, Erusalimsky, J D, Fülöp, T, Heckman, G, Howlett, S E, Khadaroo, R G, Kirkland, J L, Rodriguez Mañas, L, Marzetti, E, Paré, G, Raina, P, Rockwood, K, Sinclair, A, Skappak, C, Verschoor, C, Walter, S

“…The Canadian Frailty Network (CFN), a pan-Canadian not-for-profit organization funded by the Government of Canada through the Networks of Centres of Excellence…”
Get full text

MOLECULAR PATHOLOGY ENDPOINTS USEFUL FOR AGING STUDIES by Niedernhofer, L.J, Kirkland, J.L, Ladiges, W

“…Highlights • Designing clinical trials against fundamental processes of aging is challenging. • There is no measure of biological age, thus proxy measures are…”
Get full text

Senolytic Therapy to Modulate the Progression of Alzheimer’s Disease (SToMP-AD): A Pilot Clinical Trial by Gonzales, Mitzi M., Garbarino, V. R., Marques Zilli, E., Petersen, R. C., Kirkland, J. L., Tchkonia, T., Musi, N., Seshadri, S., Craft, S., Orr, Miranda E.

“…Preclinical studies indicate an age-associated accumulation of senescent cells across multiple organ systems. Emerging evidence suggests that tau protein…”
Get full text

Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease by Lin, Y., Postma, D. F., Steeneken, L. S., Melo dos Santos, L. S., Kirkland, J. L., Espindola‐Netto, J. M., Tchkonia, T., Borghesan, M., Bouma, H. R., Demaria, M.

“…Accurate biomarkers for predicting COVID‐19 severity have remained an unmet need due to an incomplete understanding of virus pathogenesis and heterogeneity…”
Get full text

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice by Strong, Randy, Miller, Richard A, Astle, Clinton M, Baur, Joseph A, de Cabo, Rafael, Fernandez, Elizabeth, Guo, Wen, Javors, Martin, Kirkland, James L, Nelson, James F, Sinclair, David A, Teter, Bruce, Williams, David, Zaveri, Nurulain, Nadon, Nancy L, Harrison, David E

“…The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or…”
Get full text

Preadipocyte Function and Aging: Links Between Age-Related Changes in Cell Dynamics and Altered Fat Tissue Function by Kirkland, James L., Dobson, Deborah E.

“…OBJECTIVE: To review recent findings about changes with age in the replication and differentiation of preadipocytes, the progenitor cells in fat tissue that…”
Get full text

Inflammatory characteristics of adipose tissue collected by surgical excision vs needle aspiration by Santosa, S, Swain, J, Tchkonia, T, Kirkland, J L, Jensen, M D

“…Subcutaneous adipose tissue can be obtained for research during an elective, clinically indicated operation by standard surgical excision approaches and by…”
Get full text

Age, anatomic site, and the replication and differentiation of adipocyte precursors by Kirkland, J L, Hollenberg, C H, Gillon, W S

“…The effects of donor age and anatomic site on cellular replication and differentiation were studied in adipocyte precursors cloned from epididymal and…”
Get full text

Effects of fat depot site on differentiation-dependent gene expression in rat preadipocytes by Kirkland, J L, Hollenberg, C H, Gillon, W S

“…Variability in physiological characteristics among adipose depots could be caused, in part, by mechanisms intrinsic to cells comprising the depots. To evaluate…”
Get more information

Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes by Brown, N F, Hill, J K, Esser, V, Kirkland, J L, Corkey, B E, Foster, D W, McGarry, J D

“…The outer mitochondrial membrane enzyme carnitine palmitoyltransferase I (CPT I) represents the initial and regulated step in the beta-oxidation of fatty…”
Get full text

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study by Singh, M, Jensen, M D, Lerman, A, Kushwaha, S, Rihal, C S, Gersh, B J, Behfar, A, Tchkonia, T, Thomas, R J, Lennon, R J, Keenan, L R, Moore, A G, Kirkland, J L

“…Rapamycin, an mTOR inhibitor affects senescence through suppression of senescence-associated secretory phenotype (SASP). We studied the safety and feasibility…”
Get more information

Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model by Akkad, Hazem, Cacciani, Nicola, Llano‐Diez, Monica, Corpeno Kalamgi, Rebeca, Tchkonia, Tamara, Kirkland, James L., Larsson, Lars

“…Aim Critical illness myopathy (CIM) is a consequence of modern critical care, leading to skeletal muscle atrophy/paralysis with negative consequences for…”
Get full text

Patterns Of Urine Flow And Electrolyte Excretion In Healthy Elderly People by Kirkland, J. L., Lye, Michael, Levy, D. W., Banerjee, A. K.

“…Twenty four young (mean age 29.2 years, range 25-35) and 21 elderly (mean age 66.5, range 60-80) healthy subjects collected their urine in timed aliquots over…”
Get full text

Phorbol ester inhibition of estrogen-induced uterine deoxyribonucleic acid synthesis by KIRKLAND, J. L, MURTHY, L, THOMAZY, V, HYDER, S. M, STANCEL, G. M

“…Protein kinase C (PKC) is a key regulatory enzyme in the control of growth and differentiated function in many cell types. Recently it has become clear that…”
Get full text

A Case of a Laboratory Animal Feed with High Estrogenic Activity and Its Impact on in Vivo Responses to Exogenously Administered Estrogens by Boettger-Tong, Holly, Murthy, Lata, Chiappetta, Constance, Kirkland, John L., Goodwin, Bradford, Adlercreutz, Herman, Stancel, George M., Mäkelä, Sari

“…We recently noted that immature rats failed to exhibit a normal uterine response to exogenously administered estradiol as assessed by both biochemical…”
Get full text

Tamoxifen stimulates expression of the c-fos proto-oncogene in rodent uterus by Kirkland, J L, Murthy, L, Stancel, G M

“…Estrogens regulate the in vivo expression of the c-fos proto-oncogene in rat uterus, and this regulation appears to occur at the transcriptional level. This…”
Get more information

Increasing vimentin expression associated with differentiation of human and rat preadipocytes by Teichert-Kuliszewska, K, Hamilton, B S, Roncari, D A, Kirkland, J L, Gillon, W S, Deitel, M, Hollenberg, C H

“…Alterations in the cytoskeletal apparatus constitute some of the earliest changes during assumption of an adipogenic phenotype. We examined three major…”
Get more information

Varying capacities for replication of rat adipocyte precursor clones and adipose tissue growth by WANG, H, KIRKLAND, J. L, HOLLENBERG, C. H

“…Rat adipocyte precursor populations contain clones varying in capacity for replication. In this study we explored factors controlling the frequency of clones…”
Get full text