Search Results - "Kirkham, Charmaine"

Adaptation of Nontypeable Haemophilus influenzae in Human Airways in COPD: Genome Rearrangements and Modulation of Expression of HMW1 and HMW2 by Murphy, Timothy F, Kirkham, Charmaine, D'Mello, Adonis, Sethi, Sanjay, Pettigrew, Melinda M, Tettelin, Hervé

“…Chronic obstructive pulmonary disease (COPD) is a common debilitating disorder that is the third most common cause of death globally. Chronic lower airway…”
Get full text

ATP-Binding Cassette (ABC) Transporters of the Human Respiratory Tract Pathogen, Moraxella catarrhalis: Role in Virulence by Murphy, Timothy F, Brauer, Aimee L, Johnson, Antoinette, Kirkham, Charmaine

“…Moraxella catarrhalis is a human respiratory tract pathogen that causes otitis media (middle ear infections) in children and respiratory tract infections in…”
Get full text

Role of the Zinc Uptake ABC Transporter of Moraxella catarrhalis in Persistence in the Respiratory Tract by Murphy, Timothy F, Brauer, Aimee L, Kirkham, Charmaine, Johnson, Antoinette, Koszelak-Rosenblum, Mary, Malkowski, Michael G

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Rhinovirus increases Moraxella catarrhalis adhesion to the respiratory epithelium by Dissanayake, Eishika, Brockman-Schneider, Rebecca A, Stubbendieck, Reed M, Helling, Britney A, Zhang, Zhumin, Bochkov, Yury A, Kirkham, Charmaine, Murphy, Timothy F, Ober, Carole, Currie, Cameron R, Gern, James E

“…Rhinovirus causes many types of respiratory illnesses, ranging from minor colds to exacerbations of asthma. is an opportunistic pathogen that is increased in…”
Get full text

Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of pili by Murphy, Timothy F, Kirkham, Charmaine

“…Nontypeable Haemophilus influenzae is an important cause of otitis media in children and lower respiratory tract infection in adults with chronic obstructive…”
Get full text

A clonal group of nontypeable Haemophilus influenzae with two IgA proteases is adapted to infection in chronic obstructive pulmonary disease by Murphy, Timothy F, Lesse, Alan J, Kirkham, Charmaine, Zhong, Huachun, Sethi, Sanjay, Munson, Jr, Robert S

“…Strains of nontypeable Haemophilus influenzae show enormous genetic heterogeneity and display differential virulence potential in different clinical settings…”
Get full text

Mining the Moraxella catarrhalis Genome: Identification of Potential Vaccine Antigens Expressed during Human Infection by Ruckdeschel, Elizabeth A, Kirkham, Charmaine, Lesse, Alan J, Hu, Zihua, Murphy, Timothy F

“…Moraxella catarrhalis is an important cause of respiratory infections in adults and otitis media in children. Developing an effective vaccine would reduce the…”
Get full text

Construction of a Mutant and Characterization of the Role of the Vaccine Antigen P6 in Outer Membrane Integrity of Nontypeable Haemophilus influenzae by Murphy, Timothy F, Kirkham, Charmaine, Lesse, Alan J

“…Outer membrane protein P6 is the subject of investigation as a vaccine antigen to prevent infections caused by nontypeable Haemophilus influenzae, which causes…”
Get full text

Human Immune Response to Outer Membrane Protein CD of Moraxella catarrhalis in Adults with Chronic Obstructive Pulmonary Disease by MURPHY, Timothy F, KIRKHAM, Charmaine, LIU, Dai-Fang, SETHI, Sanjay

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Analysis of Antigenic Structure and Human Immune Response to Outer Membrane Protein CD of Moraxella catarrhalis by MURPHY, T. F, KIRKHAM, C, DENARDIN, E, SETHI, S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Conservation of Outer Membrane Protein E among Strains of Moraxella catarrhalis by MURPHY, Timothy F, BRAUER, Aimee L, YUSKIW, Norine, MCNAMARA, Erin R, KIRKHAM, Charmaine

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Immunoglobulin A Protease Variants Facilitate Intracellular Survival in Epithelial Cells By Nontypeable Haemophilus influenzae That Persist in the Human Respiratory Tract in Chronic Obstructive Pulmonary Disease by Murphy, Timothy F., Kirkham, Charmaine, Gallo, Mary C., Yang, Yang, Wilding, Gregory E., Pettigrew, Melinda M.

“…Nontypeable Haemophilus influenzae (NTHi) expresses 4 IgA protease variants with distinct cleavage specificities. Two IgA protease variants (B1 and B2) mediate…”
Get full text

Expression of IgA Proteases by Haemophilus influenzae in the Respiratory Tract of Adults With Chronic Obstructive Pulmonary Disease by Murphy, Timothy F., Kirkham, Charmaine, Jones, Megan M., Sethi, Sanjay, Kong, Yong, Pettigrew, Melinda M.

“…Background. Immunoglobulin (Ig) A proteases of Haemophilus influenzae are highly specific endopeptidases that cleave the hinge region of human IgA1 and also…”
Get full text

The major heat-modifiable outer membrane protein CD is highly conserved among strains of Branhamella catarrhalis by Murphy, T F, Kirkham, C, Lesse, A J

“…The outer membrane of Branhamella catarrhalis contains a major, heat-modifiable outer membrane protein called CD which has epitopes on the surface of the…”
Get more information

Antimicrobial activity of antisense peptide-peptide nucleic acid conjugates against non-typeable Haemophilus influenzae in planktonic and biofilm forms by Otsuka, Taketo, Brauer, Aimee L, Kirkham, Charmaine, Sully, Erin K, Pettigrew, Melinda M, Kong, Yong, Geller, Bruce L, Murphy, Timothy F

“…Antisense peptide nucleic acids (PNAs) are synthetic polymers that mimic DNA/RNA and inhibit bacterial gene expression in a sequence-specific manner. To assess…”
Get full text

Changes in IgA Protease Expression Are Conferred by Changes in Genomes during Persistent Infection by Nontypeable Haemophilus influenzae in Chronic Obstructive Pulmonary Disease by Gallo, Mary C, Kirkham, Charmaine, Eng, Samantha, Bebawee, Remon S, Kong, Yong, Pettigrew, Melinda M, Tettelin, Hervé, Murphy, Timothy F

“…Nontypeable (NTHi) is an exclusively human pathobiont that plays a critical role in the course and pathogenesis of chronic obstructive pulmonary disease…”
Get full text

Sulfate-binding protein, CysP, is a candidate vaccine antigen of Moraxella catarrhalis by Murphy, Timothy F, Kirkham, Charmaine, Johnson, Antoinette, Brauer, Aimee L, Koszelak-Rosenblum, Mary, Malkowski, Michael G

“…Highlights • A new vaccine antigen of the human pathogen Moraxella catarrhalis is identified. • The sulfate binding protein, CysP, induces potentially…”
Get full text

Role of the oligopeptide permease ABC Transporter of Moraxella catarrhalis in nutrient acquisition and persistence in the respiratory tract by Jones, Megan M, Johnson, Antoinette, Koszelak-Rosenblum, Mary, Kirkham, Charmaine, Brauer, Aimee L, Malkowski, Michael G, Murphy, Timothy F

“…Moraxella catarrhalis is a strict human pathogen that causes otitis media in children and exacerbations of chronic obstructive pulmonary disease in adults,…”
Get full text

Substrate binding protein SBP2 of a putative ABC transporter as a novel vaccine antigen of Moraxella catarrhalis by Otsuka, Taketo, Kirkham, Charmaine, Johnson, Antoinette, Jones, Megan M, Murphy, Timothy F

“…Moraxella catarrhalis is a common respiratory tract pathogen that causes otitis media in children and infections in adults with chronic obstructive pulmonary…”
Get full text

The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis by Otsuka, Taketo, Kirkham, Charmaine, Brauer, Aimee, Koszelak-Rosenblum, Mary, Malkowski, Michael G, Murphy, Timothy F

“…Moraxella catarrhalis is an exclusively human pathogen that is an important cause of otitis media in children and lower respiratory tract infections in adults…”
Get full text