Search Results - "Kirken, R.A."

Activation of receptor-associated tyrosine kinase JAK2 by prolactin by RUI, H, KIRKEN, R. A, FARRAR, W. L

“…JAK family tyrosine kinases have recently been implicated in intracellular signal transduction by transmembrane cytokine receptors of the interferon (IFN) and…”
Get full text

Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors by DASILVA, L, HOWARD, O. M. Z, RUI, H, KIRKEN, R. A, FARRAR, W. L

“…Prolactin (PRL) has recently been demonstrated to induce tyrosine phosphorylation and activation of the cytoplasmic tyrosine kinase JAK2 in PRL-dependent Nb2…”
Get full text

Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase by KIRKEN, R. A, RUI, H, MALABARBA, M. G, FARRAR, W. L

“…Janus tyrosine kinase (JAK) has recently been linked to signal transduction by cytokine receptors of the hematopoietin family. We have recently described a…”
Get full text

Inhibition of JAK3 with a novel, selective and orally active small molecule induces therapeutic response in T-cell malignancies by Ross, J A, Spadaro, M, Rosado, D C, Cavallo, F, Kirken, R A, Pericle, F

Get full text

Molecular actions of sirolimus: sirolimus and mTor by Kirken, R.A, Wang, Y.L

“…Recent therapeutic strategies to combat organ allograft rejection have focused on T-cell signaling pathways and the molecules that comprise them. The macrolide…”
Get full text

Targeting Jak3 for immune suppression and allograft acceptance by Kirken, R.A.

Get full text

PNU156804 inhibits Jak3 tyrosine kinase and rat heart allograft rejection by Stepkowski, S.M., Nagy, Z.S., Wang, M.-E., Behbod, F., Erwin-Cohen, R., Kahan, B.D., Kirken, R.A.

Get full text

New approaches to transplant immunosuppression by Kahan, B.D., Kirken, R.A., Stepkowski, S.M.

“…Although considerable progress has been achieved using immunosuppressive drugs that inhibit lymphocyte activation and T-cell cytokine signal transduction…”
Get full text

Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts by Kirken, R.A, Erwin-Cohen, R, Behbod, F, Wang, M.-E, Stepkowski, S.M, Kahan, B.D

Get full text

The role of signals 1, 2, and 3 in induction of transplantation tolerance by Stepkowski, S.M., Nagy, Z.S., Kahan, B.D., Kirken, R.A.

Get full text

The role of Stat5 in the induction of regulatory t cells in transplantation tolerance by Stepkowski, S.M., Kirken, R.A., Nagy, Z.S., Trawick, B.W., Wang, M., Tejpal, N., Wang, M.-E., Tian, L., Clark, J., Kahan, B.D.

Get full text

Tolerance induction by alteration of T cell receptor (TCR) signaling using an allochimeric donor/recipient class I MHC protein by Stepkowski, S.M, Kirken, R.A, Wang, M, Yu, J, Akioka, K, Kahan, B.D

Get full text

Selective inhibition of IL-2 mRNA blocks allograft rejection by limiting T cell clonal expansion by Tian, L, Qu, X, Wang, M.E, Kirken, R.A, Bennett, F.C, Stepkowski, S.M

Get full text

High Yield Purification of a Four Subunit caa3-Type Cytochrome Oxidase from the Thermophilic Bacterium Bacillus PS3 Using Fast Protein Liquid Chromatography by Kirken, R.A., Lincoln, A.J., Fink, P.S., Prochaska, L.J.

“…The thermophilic bacterium, Bacillus PS3, was grown in a vigorously aerated nutrient broth at 65°C with 100 mM glutamic acid serving as a supplemental carbon…”
Get full text

Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit by Kirken, R.A., Rui, H, Evans, G.A., Farrar, W.L.

“…In this paper we have extended previous results on interleukin-2 receptor (IL2-R) signal transduction and focused on the interleukin-2 (IL-2)-stimulated…”
Get full text

Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models by Kirken, Robert A, Evans, Gerald A, Duhé, Roy J, DaSilva, Luis, Malabarba, M.Grazia, Erwin, Rebecca A, Farrar, William L

“…Cytokines, hormones and hematopoietic growth factors transduce biological signals across the cell membrane via a highly conserved family of single…”
Get full text