Search Results - "Kirkcaldie, Matthew T"

Focal demyelination in Alzheimer’s disease and transgenic mouse models by Mitew, Stanislaw, Kirkcaldie, Matthew T. K., Halliday, Glenda M., Shepherd, Claire E., Vickers, James C., Dickson, Tracey C.

“…We have investigated alterations in myelin associated with Aβ plaques, a major pathological hallmark of Alzheimer’s disease (AD), in human tissue and relevant…”
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Cytoskeletal changes during development and aging in the cortex of neurofilament light protein knockout mice by Liu, Yao, Staal, Jerome A., Canty, Alison J., Kirkcaldie, Matthew T. K., King, Anna E., Bibari, Olivier, Mitew, Stan T., Dickson, Tracey C., Vickers, James C.

“…The neurofilament light (NFL) subunit is considered as an obligate subunit polymer for neuronal intermediate filaments comprising the neurofilament (NF)…”
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Altered synapses and gliotransmission in Alzheimer's disease and AD model mice by Mitew, Stanislaw, Kirkcaldie, Matthew T.K, Dickson, Tracey C, Vickers, James C

“…Abstract Amyloid-β (Aβ) plaque accumulation in Alzheimer's disease (AD) is associated with glutamatergic synapse loss, but less is known about its effect on…”
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Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury by Pankhurst, Michael W, Gell, David A, Butler, Chris W, Kirkcaldie, Matthew T K, West, Adrian K, Chung, Roger S

“…Experiments with transgenic over-expressing, and null mutant mice have determined that metallothionein-I and -II (MT-I/II) are protective after brain injury…”
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Accurate and Unbiased Quantitation of Amyloid-β Fluorescence Images Using ImageSURF by O'Mara, Aidan R, Collins, Jessica M, King, Anna E, Vickers, James C, Kirkcaldie, Matthew T K

“…Images of amyloid-β pathology characteristic of Alzheimer's disease are difficult to consistently and accurately segment, due to diffuse deposit boundaries and…”
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Automatic Detection of Amyloid Beta Plaques in Somatosensory Cortex of an Alzheimer's Disease Mouse Using Deep Learning by Yoon, Heemoon, Park, Mira, Yeom, Soonja, Kirkcaldie, Matthew T. K., Summons, Peter, Lee, Sang-Hee

“…Identification of amyloid beta (<inline-formula> <tex-math notation="LaTeX">\text{A}\beta </tex-math></inline-formula>) plaques in the cerebral cortex in…”
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Changes in TDP-43 expression in development, aging, and in the neurofilament light protein knockout mouse by Liu, Yao, Atkinson, Rachel A.K, Fernandez-Martos, Carmen M, Kirkcaldie, Matthew T.K, Cui, Hao, Vickers, James C, King, Anna E

“…Abstract The transactive response DNA-binding protein 43 (TDP-43) has been identified as a neurofilament light ( NF-L ) messenger RNA (mRNA)-binding protein…”
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Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT)-I/II null mutant mice by Pankhurst, Michael W, Bennett, William, Kirkcaldie, Matthew T K, West, Adrian K, Chung, Roger S

“…Metallothionein-I and -II (MT-I/II) is produced by reactive astrocytes in the injured brain and has been shown to have neuroprotective effects. The…”
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Excitotoxicity in ALS: Overstimulation, or overreaction? by King, Anna E., Woodhouse, Adele, Kirkcaldie, Matthew T.K., Vickers, James C.

“…Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results in motor dysfunction and death, generally from respiratory…”
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Neurofilament heavy phosphorylated epitopes as biomarkers in ageing and neurodegenerative disease by De Paoli, Laura F., Kirkcaldie, Matthew T. K., King, Anna E., Collins, Jessica M.

“…Abstract From the day we are born, the nervous system is subject to insult, disease and degeneration. Aberrant phosphorylation states in neurofilaments, the…”
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The third wave: Intermediate filaments in the maturing nervous system by Kirkcaldie, Matthew T.K., Dwyer, Samuel T.

“…Intermediate filaments are critical for the extreme structural specialisations of neurons, providing integrity in dynamic environments and efficient…”
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Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net by Bucher, Ellie A., Collins, Jessica M., King, Anna E., Vickers, James C., Kirkcaldie, Matthew T. K.

“…The calcium binding protein parvalbumin is expressed in interneurons of two main morphologies, the basket and chandelier cells, which target perisomatic…”
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ImageSURF: An ImageJ Plugin for Batch Pixel-Based Image Segmentation Using Random Forests by O'Mara, Aidan, King, Anna E, Vickers, James C, Kirkcaldie, Matthew T. K

“…Image segmentation is a necessary step in automated quantitative imaging. ImageSURF is a macro-compatible ImageJ2/FIJI plugin for pixel-based image…”
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Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments by Siedler, Declan G, Chuah, Meng Inn, Kirkcaldie, Matthew T K, Vickers, James C, King, Anna E

“…Traumatic brain injury (TBI) from penetrating or closed forces to the cranium can result in a range of forms of neural damage, which culminate in mortality or…”
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The axon as a physical structure in health and acute trauma by Kirkcaldie, Matthew T.K., Collins, Jessica M.

“…•Cytoskeletal components and internal structure of the axon are reviewed in detail.•Current theories of neurofilament interactions are used to reconceptualise…”
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The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease by Collins, Jessica M., King, Anna E., Woodhouse, Adele, Kirkcaldie, Matthew T.K., Vickers, James C.

“…Traumatic brain injury is a risk factor for Alzheimer's disease (AD), however the effect of such neural damage on the onset and progression of beta-amyloid…”
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Transition to shift work: Sleep patterns, activity levels, and physiological health of early-career paramedics by Betson, Jason R., Kirkcaldie, Matthew T.K., Zosky, Graeme R., Ross, Renee M.

“…The physiological impact of transitioning from full-time study to work in occupations that involve high-stress environments and shift work may plausibly impact…”
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Axonopathy and cytoskeletal disruption in degenerative diseases of the central nervous system by Vickers, James C, King, Anna E, Woodhouse, Adele, Kirkcaldie, Matthew T, Staal, Jerome A, McCormack, Graeme H, Blizzard, Catherine A, Musgrove, Ruth E.J, Mitew, Stanislaw, Liu, Yao, Chuckowree, Jyoti A, Bibari, Olivier, Dickson, Tracey C

“…Abstract There has been growing interest in the axon as the initial focus of pathological change in a number of neurodegenerative diseases of the central…”
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Neurites containing the neurofilament-triplet proteins are selectively vulnerable to cytoskeletal pathology in Alzheimer's disease and transgenic mouse models by Mitew, Stanislaw, Kirkcaldie, Matthew T K, Dickson, Tracey C, Vickers, James C

“…Amyloid-β plaque accumulation in Alzheimer's disease (AD) is associated with dystrophic neurite (DN) formation and synapse loss in principal neurons, but…”
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Coherenceand cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net by Bucher, Ellie A, Collins, Jessica M, King, Anna E, Vickers, James C, Kirkcaldie Matthew T K

“…The calcium binding protein parvalbumin is expressed in interneurons of two main morphologies, the basket and chandelier cells, which target perisomatic…”
Get full text