Search Results - "Kirk, Joseph A."

Structure and assembly of the S-layer in C. difficile by Lanzoni-Mangutchi, Paola, Banerji, Oishik, Wilson, Jason, Barwinska-Sendra, Anna, Kirk, Joseph A., Vaz, Filipa, O’Beirne, Shauna, Baslé, Arnaud, El Omari, Kamel, Wagner, Armin, Fairweather, Neil F., Douce, Gillian R., Bullough, Per A., Fagan, Robert P., Salgado, Paula S.

“…Many bacteria and archaea possess a two-dimensional protein array, or S-layer, that covers the cell surface and plays crucial roles in cell physiology. Here,…”
Get full text

Characteristics of the Clostridium difficile cell envelope and its importance in therapeutics by Kirk, Joseph A., Banerji, Oishik, Fagan, Robert P.

“…Summary Clostridium difficile infection (CDI) is a challenging threat to human health. Infections occur after disruption of the normal microbiota, most…”
Get full text

An intact S-layer is advantageous to Clostridioides difficile within the host by Ormsby, Michael J, Vaz, Filipa, Kirk, Joseph A, Barwinska-Sendra, Anna, Hallam, Jennifer C, Lanzoni-Mangutchi, Paola, Cole, John, Chaudhuri, Roy R, Salgado, Paula S, Fagan, Robert P, Douce, Gillian R

“…Clostridioides difficile is responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin…”
Get full text

Spatial organization of Clostridium difficile S-layer biogenesis by Oatley, Peter, Kirk, Joseph A., Ma, Shuwen, Jones, Simon, Fagan, Robert P.

“…Surface layers (S-layers) are protective protein coats which form around all archaea and most bacterial cells. Clostridium difficile is a Gram-positive…”
Get full text

An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacterium by Fuchs, Manuela, Lamm-Schmidt, Vanessa, Sulzer, Johannes, Ponath, Falk, Jenniches, Laura, Kirk, Joseph A., Fagan, Robert P., Barquist, Lars, Vogel, Jörg, Faber, Franziska

“…The gram-positive human pathogen Clostridioides difficile has emerged as the leading cause of antibiotic-associated diarrhea. However, little is known about…”
Get full text

Heat shock increases conjugation efficiency in Clostridium difficile by Kirk, Joseph A., Fagan, Robert P.

“…Clostridium difficile infection has increased in incidence and severity over the past decade, and poses a unique threat to human health. However, genetic…”
Get full text

New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability by Kirk, Joseph A, Gebhart, Dana, Buckley, Anthony M, Lok, Stephen, Scholl, Dean, Douce, Gillian R, Govoni, Gregory R, Fagan, Robert P

“…There is a medical need for antibacterial agents that do not damage the resident gut microbiota or promote the spread of antibiotic resistance. We recently…”
Get more information

A cortex-specific penicillin-binding protein contributes to heat resistance in Clostridioides difficile spores by Alabdali, Yasir Adil Jabbar, Oatley, Peter, Kirk, Joseph A., Fagan, Robert P.

“…Sporulation is a complex cell differentiation programme shared by many members of the Firmicutes, the end result of which is a highly resistant, metabolically…”
Get full text

Clostridioides difficile S-Layer Protein A (SlpA) Serves as a General Phage Receptor by Royer, Alexia L M, Umansky, Andrew A, Allen, Marie-Maude, Garneau, Julian R, Ospina-Bedoya, Maicol, Kirk, Joseph A, Govoni, Gregory, Fagan, Robert P, Soutourina, Olga, Fortier, Louis-Charles

“…Therapeutic bacteriophages (phages) are being considered as alternatives in the fight against Clostridioides difficile infections. To be efficient, phages…”
Get full text

An intact S-layer is advantageous to Clostridioides difficile within the host by Michael J. Ormsby, Filipa Vaz, Joseph A. Kirk, Anna Barwinska-Sendra, Jennifer C. Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R. Chaudhuri, Paula S. Salgado, Robert P. Fagan, Gillian R Douce

“…Clostridioides difficile is responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin…”
Get full text

Clostridium difficile: cell surface biogenesis by O’Beirne, Shauna, Kirk, Joseph A., Fagan, Robert P.

“…On the C. difficile cell surface is a proteinaceous paracrystalline array, known as the S-layer. The S-layer of C. difficile is composed of two proteins: the…”
Get full text