Search Results - "Kirk, Ian P."

From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis by SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G

“…Starting from adenosine triphosphate (ATP), the identification of a novel series of P2Y(12) receptor antagonists and exploitation of their SAR is described…”
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The C6‐2B glioma cell P2YAC receptor is pharmacologically and molecularly identical to the platelet P2Y12 receptor by Jin, Jianguo, Tomlinson, Wendy, Kirk, Ian P, Kim, Young B, Humphries, Robert G, Kunapuli, Satya P

“…P2Y receptor activation in many cell types leads to phospholipase C activation and accumulation of inositol phosphates, while in blood platelets, C6‐2B glioma…”
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Adenosine A2a receptor-mediated modulation of striatal [3H]GABA and [3H]acetylcholine release by Kirk, I P, Richardson, P J

“…The ability of adenosine agonists to modulate K(+)-evoked gamma-[3H]aminobutyric acid ([3H]GABA) and acetylcholine (ACh) release from rat striatal synaptosomes…”
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Inhibition by KF17837 of adenosine A2A receptor‐mediated modulation of striatal GABA and ACh release by Kurokawa, Masako, Kirk, Ian P., Kirkpatrick, Karen A., Kase, Hiroshi, Richardson, Peter J.

“…1 The effect of the A2A adenosine receptor agonist, 2‐p‐(‐2‐carboxyethyl)phenethyl‐amino‐5′‐N‐ethylcarboxamidoadenosine (CGS 21680) on the potassium evoked…”
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The C6‐2B glioma cell P2Y AC receptor is pharmacologically and molecularly identical to the platelet P2Y 12 receptor by Jin, Jianguo, Tomlinson, Wendy, Kirk, Ian P, Kim, Young B, Humphries, Robert G, Kunapuli, Satya P

“…P2Y receptor activation in many cell types leads to phospholipase C activation and accumulation of inositol phosphates, while in blood platelets, C6‐2B glioma…”
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From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis by Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.

“…Starting with ATP, the identification of novel P2Y 12 receptor antagonists are described. The leading compound, 17 (AZD6140), is currently in a phase III…”
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Inhibition of striatal GABA release by the adenosine A2a receptor is not mediated by increases in cyclic AMP by Kirk, I P, Richardson, P J

“…The adenosine A2a receptor inhibition of potassium (15 mM)-evoked GABA release from striatal nerve terminals has been examined. High extracellular calcium…”
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Further characterization of [3H]‐CGS 21680 binding sites in the rat striatum and cortex by Kirk, Ian P., Richardson, Peter J.

“…1 The putative high affinity binding site for the adenosine A2A receptor agonist 2‐p‐(2‐carboxyethyl)phenethyl‐amino‐5′‐N‐ ethylcarboxamidoadenosine (CGS…”
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Inhibition by KF17837 of adenosine A 2A receptor‐mediated modulation of striatal GABA and ACh release by Kurokawa, Masako, Kirk, Ian P., Kirkpatrick, Karen A., Kase, Hiroshi, Richardson, Peter J.

“…The effect of the A 2A adenosine receptor agonist, 2‐ p ‐(‐2‐carboxyethyl)phenethyl‐amino‐5′‐N‐ethylcarboxamidoadenosine (CGS 21680) on the potassium evoked…”
Get full text