Search Results - "Kirk, C.J"

Non-genomic effects of endocrine disrupters: Inhibition of estrogen sulfotransferase by phenols and chlorinated phenols by Harris, R.M., Kirk, C.J., Waring, R.H.

“…Phenols are used world-wide and their presence in the environment is a cause of increasing concern. Despite evidence to suggest that, in general, they bind…”
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Use of Isosorbide Dinitrate/Hydralazine in the Pediatric Cardiac Population by Frandsen, E.L., Kirk, C.J., Law, Y.M., Musa, N., Files, M.D.

“…The combination of isosorbide dinitrate/hydralazine (ISDN/HYD) offers direct arterial and venous vasodilation without adversely affecting renal function. It is…”
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Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells by Franke, N E, Niewerth, D, Assaraf, Y G, van Meerloo, J, Vojtekova, K, van Zantwijk, C H, Zweegman, S, Chan, E T, Kirk, C J, Geerke, D P, Schimmer, A D, Kaspers, G J L, Jansen, G, Cloos, J

“…Proteasome inhibition is a novel treatment for several hematological malignancies. However, resistance to the proteasome inhibitor bortezomib (BTZ, Velcade) is…”
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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects by Hurchla, M A, Garcia-Gomez, A, Hornick, M C, Ocio, E M, Li, A, Blanco, J F, Collins, L, Kirk, C J, Piwnica-Worms, D, Vij, R, Tomasson, M H, Pandiella, A, San Miguel, J F, Garayoa, M, Weilbaecher, K N

“…Proteasome inhibitors (PIs), namely bortezomib, have become a cornerstone therapy for multiple myeloma (MM), potently reducing tumor burden and inhibiting…”
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A novel Bruton’s tyrosine kinase inhibitor CC-292 in combination with the proteasome inhibitor carfilzomib impacts the bone microenvironment in a multiple myeloma model with resultant antimyeloma activity by Eda, H, Santo, L, Cirstea, D D, Yee, A J, Scullen, T A, Nemani, N, Mishima, Y, Waterman, P R, Arastu-Kapur, S, Evans, E, Singh, J, Kirk, C J, Westlin, W F, Raje, N S

“…Bruton’s tyrosine kinase (Btk) modulates B-cell development and activation and has an important role in antibody production. Interestingly, Btk may also affect…”
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Structure and colour properties in the Egyptian Blue Family, M1−xM′xCuSi4O10, as a function of M, M′ where M, M′=Ca, Sr and Ba by Kendrick, E., Kirk, C.J., Dann, S.E.

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Phytoestrogens and xenoestrogens: The contribution of diet and environment to endocrine disruption by Waring, R.H., Ayers, S., Gescher, A.J., Glatt, H.-R., Meinl, W., Jarratt, P., Kirk, C.J., Pettitt, T., Rea, D., Harris, R.M.

“…Some endocrine disrupting compounds such as phthalates and phenols act non-genomically by inhibiting the sulfotransferase (SULT 1E1 and SULT 1A1) isoforms…”
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Structure and colour properties in the Egyptian Blue Family, M 1− x M′ x CuSi 4O 10, as a function of M, M′ where M, M′ = Ca, Sr and Ba by Kendrick, E., Kirk, C.J., Dann, S.E.

“…Solid solutions in the Egyptian Blue Family, M 1− x M′ x CuSi 4O 10, where M, M′ are the alkali-earth cations Ca, Sr and Ba, have been successfully synthesised…”
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Estrogenic Alkylphenols Induce Cell Death by Inhibiting Testis Endoplasmic Reticulum Ca2+ Pumps by Hughes, P.J., McLellan, H., Lowes, D.A., Kahn, S.Zafar, Bilmen, J.G., Tovey, S.C., Godfrey, R.E., Michell, R.H., Kirk, C.J., Michelangeli, F.

“…Industrial alkylphenols in the environment may act as “xenoestrogens” to disrupt testicular development and decrease male fertility. Amongst possible targets…”
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Hepatic action of vasopressin: Lack of a role for adenosine-3′,5′-cyclic monophosphate by Kirk, C.J., Hems, D.A.

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Carotid Artery Patency and Neurodevelopmental Outcomes After Decannulation in Pediatric Extracorporeal Life Support by Kwon, Eustina G., Anderson, Jamie E., DiGeronimo, Robert, Kirk, Christa C.J., Billimoria, Zeenia C., Rothstein, David H., Stark, Rebecca, McMullan, D. Michael, Brogan, Thomas V., Riehle, Kimberly J., Rice–Townsend, Samuel E.

“…Decannulation from veno-arterial extracorporeal life support may involve ligation or repair of the carotid artery; however, differences in outcomes are not…”
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Substrate characterisation of a recombinant sulfotransferase SULT1 and mRNA expression in chub ( Leuciscus cephalus) tissues by Assem, F.L., Kirk, C.J., Chipman, J.K.

“…We have studied the role and regulation of sulfonation of xenobiotics and endogenous substrates in Leuciscus cephalus, an abundant and environmentally relevant…”
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Interactions between the frequency of viral infections and IFN-γ production in the first year of life by DaSilva, D.F., Roberg, K.A., Carlson-Dakes, K.T., Tisler, C.J., Shen, K., Shult, P.A., Kirk, C.J., Gangnon, R.E., Gern, J.E., Lemanske, R.F.

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Development of a novel nasal lavage device to obtain nasopharyngeal mucus samples for viral identificaion in infancy by Anderson, E.L., Roberg, K.A., Carlson-Dakes, K.T., DaSilva, D.F., Shult, P.A., Kirk, C.J., Evans, M., Li, Z., Gangnon, R., Gern, J.E., Lemanske, R.F.

“…To develop a patient-acceptable technique for nasal lavage (NL) during infancy to identify viral pathogens producing wheezing illnesses. In prospective…”
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Increased frequency and severity of viral infections during infancy is associated with recurrent wheezing in the first three years of life by Da Silva, D.F.G., Roberg, K.A., Tisler, C.J., Anderson, E.L., Hiemke, H.J., Pappas, T.E., Shult, P.A., Kirk, C.J., Gangnon, R.E., Li, Z., Evans, M.D., Gern, J.E., Lemanske, R.F.

“…The frequency and nature of viral infections during infancy may contribute to the subsequent development of various wheezing phenotypes and/or asthma. The…”
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A dietary study to investigate the effects of Soya milk ingestion on steroid hormone biosynthesis in women with a high risk of developing breast cancer compared to those at normal risk by Ayers, S.J, Harris, R.M, Rea, D.W, Wood, D.M, Bottomley, L, Waring, R.H, Williamson, J, Lee, M, Kirk, C.J

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632 Frequency and etiology of respiratory tract illnesses in infants with a maternal history of allergies and/or asthma by Roberg, K.A, Carlson-Dakes, K.T, Anklam, K.S, Adler, K.J, Line, M.R, Ellerman, S.A, Yoshihara, D, Sund, M, DaSilva, D.F, Zeng, L, Kosorok, M.R, Schult, P.A, Kirk, C.J, Gern, J.E, Lemanske, R.F

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Inositol 1,2,3-trisphosphate is a product of InsP6 dephosphorylation in WRK-1 rat mammary epithelial cells and exhibits transient concentration changes during the cell cycle by Barker, C J, Wright, J, Kirk, C J, Michell, R H

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Mechanisms of phospholipase C activation: a comparison with the adenylate cyclase system by Guillon, G, Balestre, M N, Mouillac, B, Berrada, R, Kirk, C J

“…Many hormones, neurotransmitters or other signaling molecules exert their biological activities through the stimulation of a specific phospholipase C. Once…”
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