Search Results - "Kirk, A.D"

Costimulation Blockade Alters Germinal Center Responses and Prevents Antibody‐Mediated Rejection by Kim, E. J., Kwun, J., Gibby, A. C., Hong, J. J., Farris, A. B., Iwakoshi, N. N., Villinger, F., Kirk, A. D., Knechtle, S. J.

“…De novo donor‐specific antibody (DSA) after organ transplantation promotes antibody‐mediated rejection (AMR) and causes late graft loss. Previously, we…”
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The Role of Donor‐Specific HLA Alloantibodies in Liver Transplantation by O'Leary, J. G., Demetris, A. J., Friedman, L. S., Gebel, H. M., Halloran, P. F., Kirk, A. D., Knechtle, S. J., McDiarmid, S. V., Shaked, A., Terasaki, P. I., Tinckam, K. J., Tomlanovich, S. J., Wood, K. J., Woodle, E. S., Zachary, A. A., Klintmalm, G. B.

“…The impact of donor‐specific HLA alloantibodies (DSA) on short‐ and long‐term liver transplant outcome is not clearly defined. While it is clear that not all…”
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Superiority of Rapamycin Over Tacrolimus in Preserving Nonhuman Primate Treg Half‐Life and Phenotype After Adoptive Transfer by Singh, K., Stempora, L., Harvey, R. D., Kirk, A. D., Larsen, C. P., Blazar, B. R., Kean, L. S.

“…Many critical issues remain concerning how best to deploy adoptive regulatory T cell (Treg) immunotherapy to the clinic. These include a determination of their…”
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CD40‐Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates by Thompson, P., Cardona, K., Russell, M., Badell, I. R., Shaffer, V., Korbutt, G., Rayat, G. R., Cano, J., Song, M., Jiang, W., Strobert, E., Rajotte, R., Pearson, T., Kirk, A. D., Larsen, C. P.

“…The widespread clinical implementation of alloislet transplantation as therapy for type 1 diabetes has been hindered by the lack of suitable islet donors…”
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Islet Xenotransplantation Using Gal‐Deficient Neonatal Donors Improves Engraftment and Function by Thompson, P., Badell, I. R., Lowe, M., Cano, J., Song, M., Leopardi, F., Avila, J., Ruhil, R., Strobert, E., Korbutt, G., Rayat, G., Rajotte, R., Iwakoshi, N., Larsen, C. P., Kirk, A. D.

“…Significant deficiencies in understanding of xenospecific immunity have impeded the success of preclinical trials in xenoislet transplantation. Although…”
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Class II Alloantibody and Mortality in Simultaneous Liver‐Kidney Transplantation by O'Leary, J. G., Gebel, H. M., Ruiz, R., Bray, R. A., Marr, J. D., Zhou, X. J., Shiller, S. M., Susskind, B. M., Kirk, A. D., Klintmalm, G. B.

“…Hyperacute kidney rejection is unusual in crossmatch positive recipients of simultaneous liver–kidney transplants (SLKT). However, recent data suggest that…”
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High CTLA‐4 Expression on Th17 Cells Results in Increased Sensitivity to CTLA‐4 Coinhibition and Resistance to Belatacept by Krummey, S. M., Cheeseman, J. A., Conger, J. A., Jang, P. S., Mehta, A. K., Kirk, A. D., Larsen, C. P., Ford, M. L.

“…The CD28/cytotoxic T‐lymphocyte antigen 4 (CTLA‐4) blocker belatacept selectively inhibits alloreactive T cell responses but is associated with a high…”
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Monocyte Infiltration and Kidney Allograft Dysfunction During Acute Rejection by Girlanda, R., Kleiner, D. E., Duan, Z., Ford, E. A. S., Wright, E. C., Mannon, R. B., Kirk, A. D.

“…Multiple cell types infiltrate acutely rejecting renal allografts. Typically, monocytes and T cells predominate. Although T cells are known to be required for…”
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Nondepleting Anti‐CD40‐Based Therapy Prolongs Allograft Survival in Nonhuman Primates by Badell, I. R., Thompson, P. W., Turner, A. P., Russell, M. C., Avila, J. G., Cano, J. A., Robertson, J. M., Leopardi, F. V., Strobert, E. A., Iwakoshi, N. N., Reimann, K. A., Ford, M. L., Kirk, A. D., Larsen, C. P.

“…Costimulation blockade of the CD40/CD154 pathway has been effective at preventing allograft rejection in numerous transplantation models. This strategy has…”
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Dual Islet Transplantation Modeling of the Instant Blood‐Mediated Inflammatory Reaction by Martin, B. M., Samy, K. P., Lowe, M. C., Thompson, P. W., Cano, J., Farris, A. B., Song, M., Dove, C. R., Leopardi, F. V., Strobert, E. A., Jenkins, J. B., Collins, B. H., Larsen, C. P., Kirk, A. D.

“…Islet xenotransplantation is a potential treatment for diabetes without the limitations of tissue availability. Although successful experimentally, early islet…”
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CTLA4Ig Prevents Alloantibody Formation Following Nonhuman Primate Islet Transplantation Using the CD40‐Specific Antibody 3A8 by Badell, I. R., Russell, M. C., Cardona, K., Shaffer, V. O., Turner, A. P., Avila, J. G., Cano, J. A., Leopardi, F. V., Song, M., Strobert, E. A., Ford, M. L., Pearson, T. C., Kirk, A. D., Larsen, C. P.

“…Islet transplantation to treat type 1 diabetes has been limited in part by toxicities of current immunosuppression and recipient humoral sensitization…”
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Patterns of De Novo Allo B Cells and Antibody Formation in Chronic Cardiac Allograft Rejection After Alemtuzumab Treatment by Kwun, J., Oh, B. C., Gibby, A. C., Ruhil, R., Lu, V. T., Kim, D. W., Page, E. K., Bulut, O. P., Song, M. Q., Farris, A. B., Kirk, A. D., Knechtle, S. J., Iwakoshi, N. N.

“…Even though the etiology of chronic rejection (CR) is multifactorial, donor specific antibody (DSA) is considered to have a causal effect on CR development…”
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Antibody‐Mediated Rejection—An Ounce of Prevention Is Worth a Pound of Cure by Bradley, J. A., Baldwin, W. M., Bingaman, A., Ellenrieder, C., Gebel, H. M., Glotz, D., Kirk, A. D.

“…The presence of preformed, donor‐specific alloantibodies inpatients undergoing renal transplantation is associated with a high risk of hyperacute and acute…”
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A Novel Monoclonal Antibody to CD40 Prolongs Islet Allograft Survival by LOWE, M, BADELL, I. R, ADAMS, A. B, KIRK, A. D, LARSEN, C. P, REIMANN, K. A, THOMPSON, P, MARTIN, B, LEOPARDI, F, STROBERT, E, PRICE, A. A, ABDULKERIM, H. S, WANG, R, IWAKOSHI, N. N

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Exhausted T Helper Cells in Lung Transplantation Portend Worse Outcome by Chao, F.-Y, Lockard, C, Force, S.D, Fernandez, F, Pickens, A, Bag, R, Lawrence, E.C, Kirk, A.D, Neujahr, D.C

“…Purpose In chronic viral infections, CD4 exhaustion correlates with poor containment of virus. We predicted that high levels of CD4 exhaustion would be…”
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Evidence for Kidney Rejection After Combined Bone Marrow and Renal Transplantation Despite Ongoing Whole‐Blood Chimerism in Rhesus Macaques by Ramakrishnan, S. K., Page, A., Farris, A. B., Singh, K., Leopardi, F., Hamby, K., Sen, S., Polnett, A., Deane, T., Song, M., Stempora, L., Strobert, E., Kirk, A. D., Larsen, C. P., Kean, L. S.

“…Although there is evidence linking hematopoietic chimerism induction and solid organ transplant tolerance, the mechanistic requirements for chimerism‐induced…”
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Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report by Cendales, L., Bray, R., Gebel, H., Brewster, L., Elbein, R., Farthing, D., Song, M., Parker, D., Stillman, A., Pearson, T., Kirk, A.D.

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150: Flow Cytometric Parameters of CD8 Lavage Cells in Detection of Acute Cellular Rejection in Lung Transplant by Neujahr, D.C, Mohammed, A, Ulukpo, O, Pelaez, A, Ramirez, A, Lawrence, E.C, Force, S.D, Gal, A.A, Larsen, C.P, Kirk, A.D

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455: Surgical Repair of Gastroesophageal Reflux in Lung Transplant Recipients Is Associated with Decreased Armed Effector T Cells and Increased Exhausted T Cells within the Allograft by Neujahr, D.C, Pelaez, A, Ramirez, A, Force, S.D, Lawrence, E.C, Cardona, A.C, Kirk, A.D, Larsen, C.P

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Cumulative Exposure to CD8+ Granzyme Bhi T Cells Is Associated with Reduced Lung Function Early after Lung Transplantation by Mohammed, A, Ulukpo, O, Lawrence, E.C, Fernandez, F, Pickens, A, Gal, A.A, Force, S.D, Easley, K.C, Larsen, C.P, Kirk, A.D, Neujahr, D.C

“…Abstract Outcomes following lung transplant remain suboptimal. This is attributable to variable posttransplant recovery of lung function, and inconsistent…”
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