Search Results - "Kirill, Lepik"

Overcoming the delivery problem for therapeutic genome editing: Current status and perspective of non-viral methods by Mashel, Tatiana V., Tarakanchikova, Yana V., Muslimov, Albert R., Zyuzin, Mikhail V., Timin, Alexander S., Lepik, Kirill V., Fehse, Boris

“…Besides its broad application in research and biotechnology, genome editing (GE) has great potential for clinical gene therapy, but delivery of GE tools…”
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Relapsed and refractory classical Hodgkin lymphoma immunotherapy by Kirill Lepik

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A comparison study between electrospun polycaprolactone and piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds for bone tissue engineering by Gorodzha, Svetlana N., Muslimov, Albert R., Syromotina, Dina S., Timin, Alexander S., Tcvetkov, Nikolai Y., Lepik, Kirill V., Petrova, Aleksandra V., Surmeneva, Maria A., Gorin, Dmitry A., Sukhorukov, Gleb B., Surmenev, Roman A.

“…[Display omitted] •Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds with SiHA were investigated.•Piezoelectric scaffolds with SiHA stimulated adhesion…”
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The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics by Muslimov, Albert, Tereshchenko, Valeriy, Shevyrev, Daniil, Rogova, Anna, Lepik, Kirill, Reshetnikov, Vasiliy, Ivanov, Roman

“…Advances in molecular biology have revolutionized the use of messenger RNA (mRNA) as a therapeutic. The concept of nucleic acid therapy with mRNA originated in…”
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Efficient gene editing via non-viral delivery of CRISPR–Cas9 system using polymeric and hybrid microcarriers by Timin, Alexander S., Muslimov, Albert R., Lepik, Kirill V., Epifanovskaya, Olga S., Shakirova, Alena I., Mock, Ulrike, Riecken, Kristoffer, Okilova, Maria V., Sergeev, Vladislav S., Afanasyev, Boris V., Fehse, Boris, Sukhorukov, Gleb B.

“…CRISPR–Cas9 is a revolutionary genome-editing technology that has enormous potential for the treatment of genetic diseases. However, the lack of efficient and…”
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Efficacy and safety of nivolumab combined with brentuximab vedotin after nivolumab monotherapy failure in patients with relapsed and refractory classic Hodgkin lymphoma by Fedorova, Liudmila V., Lepik, Kirill V., Volkov, Nikita P., Kotselyabina, Polina V., Borzenkova, Evgenia S., Popova, Marina O., Beynarovich, Anastasia V., Baykov, Vadim V., Kozlov, Andrey V., Moiseev, Ivan S., Mikhailova, Natalia B., Kulagin, Alexander D.

“…Objectives Therapy of patients with relapsed and refractory classic Hodgkin lymphoma (r/r cHL) after PD-1 inhibitors failure remains an unresolved issue. The…”
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DDAO Controlled Synthesis of Organo-Modified Silica Nanoparticles with Encapsulated Fluorescent Boron Dipyrrins and Study of Their Uptake by Cancerous Cells by Goncharenko, Aleksandr A, Tarasyuk, Ilya A, Marfin, Yuriy S, Grzhegorzhevskii, Kirill V, Muslimov, Albert R, Bondarenko, Andrey B, Lebedev, Maxim D, Kuz'min, Ilya A, Vashurin, Artur S, Lepik, Kirill V, Timin, Alexander S, Rumyantsev, Evgeniy V

“…The design of cargo carriers with high biocompatibility, unique morphological characteristics, and capability of strong bonding of fluorescent dye is highly…”
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Hybrid inorganic-organic capsules for efficient intracellular delivery of novel siRNAs against influenza A (H1N1) virus infection by Timin, Alexander S., Muslimov, Albert R., Petrova, Aleksandra V., Lepik, Kirill V., Okilova, Maria V., Vasin, Andrey V., Afanasyev, Boris V., Sukhorukov, Gleb B.

“…The implementation of RNAi technology into the clinical practice has been significantly postponing due to the issues regarding to the delivery of naked siRNA…”
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Safe and Effective Delivery of Antitumor Drug Using Mesenchymal Stem Cells Impregnated with Submicron Carriers by Timin, Alexander S, Peltek, Oleksii O, Zyuzin, Mikhail V, Muslimov, Albert R, Karpov, Timofey E, Epifanovskaya, Olga S, Shakirova, Alena I, Zhukov, Mikhail V, Tarakanchikova, Yana V, Lepik, Kirill V, Sergeev, Vladislav S, Sukhorukov, Gleb B, Afanasyev, Boris V

“…An important area in modern malignant tumor therapy is the optimization of antitumor drugs pharmacokinetics. The use of some antitumor drugs is limited in…”
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Strategies to Circumvent the Side-Effects of Immunotherapy Using Allogeneic CAR-T Cells and Boost Its Efficacy: Results of Recent Clinical Trials by Smirnov, Sergei, Petukhov, Alexey, Levchuk, Ksenia, Kulemzin, Sergey, Staliarova, Alena, Lepik, Kirill, Shuvalov, Oleg, Zaritskey, Andrey, Daks, Alexandra, Fedorova, Olga

“…Despite the outstanding results of treatment using autologous chimeric antigen receptor T cells (CAR-T cells) in hematological malignancies, this approach is…”
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In search of an ideal template for therapeutic genome editing: A review of current developments for structure optimization by Shakirova, Alena, Karpov, Timofey, Komarova, Yaroslava, Lepik, Kirill

“…Gene therapy is a fast developing field of medicine with hundreds of ongoing early-stage clinical trials and numerous preclinical studies. Genome editing (GE)…”
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One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles by Kopoleva, Elena, Lebedev, Maksim D., Postovalova, Alisa, Rogova, Anna, Fatkhutdinova, Landysh, Epifanovskaya, Olga, Goncharenko, Alexander A., Kremleva, Arina V., Domracheva, Nadezhda, Bukatin, Anton S., Muslimov, Albert R., Koroleva, Aleksandra, Zhizhin, Evgeniy V., Lepik, Kirill V., Timin, Alexander S., Peltek, Oleksii, Zyuzin, Mikhail V.

“…Redox-responsive drug delivery systems present a promising avenue for drug delivery due to their ability to leverage the unique redox environment within tumor…”
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Therapeutic Vaccines for Follicular Lymphoma: A Systematic Review by Suponin, Andrei, Zhelnov, Pavel, Potanin, Artem, Chekalov, Andrey, Lomazov, Aleksandr, Vladimirova, Kseniia, Lepik, Kirill, Muslimov, Albert

“…(1) Background: We aimed to estimate the pooled effectiveness and safety of vaccination in follicular lymphoma (FL) and discuss implications for immunotherapy…”
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Nivolumab discontinuation and retreatment in patients with relapsed or refractory Hodgkin lymphoma by Fedorova, Liudmila V., Lepik, Kirill V., Mikhailova, Natalia B., Kondakova, Elena V., Zalyalov, Yuri R., Baykov, Vadim V., Babenko, Elena V., Kozlov, Andrey V., Moiseev, Ivan S., Afanasyev, Boris V.

“…Immune checkpoint inhibitors (ICI) have demonstrated high therapeutic efficacy in relapsed or refractory classical Hodgkin lymphoma (r/r cHL). Nevertheless,…”
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Layer‐by‐Layer‐Assembled Capsule Size Affects the Efficiency of Packaging and Delivery of Different Genetic Cargo by Tarakanchikova, Yana V., Muslimov, Albert R., Zyuzin, Mikhail V., Nazarenko, Irina, Timin, Alexander S., Sukhorukov, Gleb B., Lepik, Kirill V.

“…The lack of an efficient and versatile intracellular nucleic acids delivery platform impedes the clinical implementation of gene therapy. Advances in…”
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Favorable outcomes of allogeneic hematopoietic stem cell transplantation with fludarabine–bendamustine conditioning and posttransplantation cyclophosphamide in classical Hodgkin lymphoma by Beynarovich, Anastasia, Lepik, Kirill, Mikhailova, Natalia, Borzenkova, Evgenia, Volkov, Nikita, Moiseev, Ivan, Zalyalov, Yuri, Kondakova, Elena, Kozlov, Andrey, Stelmakh, Lilia, Pirogova, Olga, Zubarovskaya, Lyudmila, Kulagin, Alexander, Afanasyev, Boris

“…Introduction Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for patients with relapsed and refractory…”
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Nivolumab for the treatment of relapsed and refractory classical Hodgkin lymphoma after ASCT and in ASCT-naïve patients by Lepik, Kirill V., Mikhailova, Natalia B., Moiseev, Ivan S., Kondakova, Elena V., Tsvetkova, Luibov A., Zalyalov, Yuri R., Borzenkova, Evgeniya S., Babenko, Elena V., Baykov, Vadim V., Markova, Inna V., Afanasyev, Boris V.

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Intracellular redox induced drug release in cancerous and mesenchymal stem cells by Timin, Alexander S., Lepik, Kirill V., Muslimov, Albert R., Gorin, Dmitry A., Afanasyev, Boris V., Sukhorukov, Gleb B.

“…•Redox-responsive microcapsules with covalently bonded drug were prepared.•Drug-conjugated capsules showed high uptake efficacy against cancerous cells.•The…”
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N-[4-(N,N,N-Trimethylammonium)Benzyl]Chitosan Chloride as a Gene Carrier: The Influence of Polyplex Composition and Cell Type by Raik, Sergei V., Mashel, Tatiana V., Muslimov, Albert R., Epifanovskaya, Olga S., Trofimov, Mikhail A., Poshina, Daria N., Lepik, Kirill V., Skorik, Yury A.

“…Polyplex-based gene delivery systems are promising substitutes for viral vectors because of their high versatility and lack of disadvantages commonly…”
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P1179: PROGNOSIS OF PATIENTS WITH AGGRESSIVE REFRACTORY B‐NHL TREATED WITH GLOFITAMAB IN REAL CLINICAL PRACTICE by Fedorova, Liudmila, Smykova, Olesia, Kirill, Lepik, Markelov, Vladislav, Popova, Marina, Kondakova, Elena, Moiseev, Ivan, Mikhailova, Natalia, Kulagin, Alexander

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