Search Results - "Kircik, Leon H"

Androgens, Androgen Receptors, and the Skin: From the Laboratory to the Clinic With Emphasis on Clinical and Therapeutic Implications by Del Rosso, James Q, Kircik, Leon H, Stein Gold, Linda, Thiboutot, Diane

“…The effects of androgens on human skin include growth and differentiation of sebaceous glands, terminal hair growth, epidermal barrier function, wound healing,…”
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Dermal sensitization, safety, and tolerability of triple-combination clindamycin phosphate 1.2%/benzoyl peroxide 3.1%/adapalene 0.15% gel from three clinical trials by Draelos, Zoe D., Tanghetti, Emil A., Kircik, Leon H., Bhatia, Neal, Zeichner, Joshua A., Sugarman, Jeffrey L., Stein Gold, Linda

“…Using a three-pronged acne treatment approach-combining an antibiotic, antimicrobial agent, and retinoid-may provide greater efficacy than monad or dyad…”
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Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin by Tanghetti, Emil A., Zeichner, Joshua A., Gold, Michael, Sadick, Neil, Cook-Bolden, Fran E., Kircik, Leon H., Stein Gold, Linda, Weiss, Jonathan, Tyring, Stephen K., Del Rosso, James Q., Guenin, Eric

“…Excessive sebum production is a factor in acne development. Tazarotene 0.045% lotion has demonstrated reductions in acne lesions and acne-induced sequelae…”
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Triple Combination Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% for Acne: Efficacy and Safety from a Pooled Phase 3 Analysis by Kircik, Leon H., Stein Gold, Linda, Gold, Michael, Weiss, Jonathan S., Harper, Julie C., Del Rosso, James Q., Bunick, Christopher G., Bhatia, Neal, Tanghetti, Emil A., Eichenfield, Lawrence F., Baldwin, Hilary, Draelos, Zoe D., Callender, Valerie D., Han, George, Gooderham, Melinda J., Sadick, Neil, Lupo, Mary P., Lain, Edward (Ted), Werschler, William Philip

“…Introduction A three-pronged approach to acne treatment combining an antibiotic, antimicrobial, and retinoid may be more efficacious than single/double…”
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Importance of Vehicles in Topical Treatment of Fungal Infections by Kircik, Leon H., MD

“…Topical drug therapies are commonly used to manage dermatologic diseases and their manifestations in the skin, hair, nails, and mucous membranes. Compared with…”
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Game Changer in Acne Treatment by Kircik, Leon H

“…Of the four primary pathogenic factors that drive acne vulgaris-androgen excess, increased sebum production, faulty keratinization, and overgrowth of C…”
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Preference for Cal/BDP Cream or Foam in Patients With Mild to Moderate Plaque Psoriasis by Kircik, Leon H, Draelos, Zoe Diana, Glick, Brad, Green, Lawrence, Burgess, Cheryl

“…The combined use of topical calcipotriol/betamethasone dipropionate (Cal/BDP) is commonly used and demonstrated to be effective for the management of psoriasis…”
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A Novel Technology: Sunscreen With Actinic Damage Repair by Kircik Md, Leon H

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Addressing the Challenges of Treating Actinic Keratosis by Kircik, Leon H.

“…Actinic keratosis (AK) represents one of the most common diagnoses in our dermatology practices. The incidence of AK lesions continues to rise, along with that…”
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Trial of Roflumilast Cream for Chronic Plaque Psoriasis by Lebwohl, Mark G, Papp, Kim A, Stein Gold, Linda, Gooderham, Melinda J, Kircik, Leon H, Draelos, Zoe D, Kempers, Steven E, Zirwas, Mathew, Smith, Kathleen, Osborne, David W, Trotman, Marie-Louise, Navale, Lynn, Merritt, Charlotte, Berk, David R, Welgus, Howard

“…A cream formulation of the phosphodiesterase type 4 inhibitor roflumilast, in two concentrations, led to higher percentages of patients with clearance or…”
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Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study by Kircik, Leon H

“…Although there are few differences in the incidence and pathophysiology of acne across various races and ethnicities, there is some evidence that black…”
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Effect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials by Lebwohl, Mark G, Kircik, Leon H, Moore, Angela Y, Stein Gold, Linda, Draelos, Zoe D, Gooderham, Melinda J, Papp, Kim A, Bagel, Jerry, Bhatia, Neal, Del Rosso, James Q, Ferris, Laura K, Green, Lawrence J, Hebert, Adelaide A, Jones, Terry, Kempers, Steven E, Pariser, David M, Yamauchi, Paul S, Zirwas, Matthew, Albrecht, Lorne, Devani, Alim R, Lomaga, Mark, Feng, Amy, Snyder, Scott, Burnett, Patrick, Higham, Robert C, Berk, David R

“…IMPORTANCE: Once-daily roflumilast cream, 0.3%, a potent phosphodiesterase 4 inhibitor, demonstrated efficacy and was well tolerated in a phase 2b trial of…”
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Depression? It's the Disease NOT the Drug by Kircik, Leon H

“…Research into the immunopathological mechanisms of plaque psoriasis has produced increasingly targeted biologic therapies. The specificity of these agents…”
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Yes to Appropriate Compounding, No to Illegal Compounding by Kircik, Leon H

“…Dermatology is often described as a "visual" specialty. While it is true that many of our diagnoses can be made based on a relatively quick recognition of…”
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The New Psoriasis Paradigm: Striving for Complete Clearance by Kircik, Leon H

“…Newer biologics have introduced the possibility of higher and more complete clearance rates than previously possible. For many patients, PASI 90 and PASI 100…”
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Use of Dapsone 5% Gel as Maintenance Treatment of Acne Vulgaris Following Completion of Oral Doxycycline and Dapsone 5% Gel Combination Treatment by Kircik, Leon H

“…Acne vulgaris is a common, chronic skin disease that requires long-term therapy. Oral antibiotics are a mainstay of treatment, but extended use is associated…”
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Dermal sensitization, safety, tolerability, and patient preference of tazarotene 0.045% lotion from five clinical trials by Kircik, Leon H., Green, Lawrence, Guenin, Eric, Khalid, Waleed, Alexander, Binu

“…Topical retinoids are recommended for acne treatment, but their use may be limited by irritation or dermatitis. Herein is an overview of the dermal…”
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Fixed Combination of Clindamycin Phosphate 1.2% and Benzoyl Peroxide 3.75% Aqueous Gel: Long-Term Use in Adult Females With Moderate Acne Vulgaris by Kircik, Leon H

“…OBJECTIVE: To evaluate long-term efficacy and safety of a fixed combination clindamycin phosphate 1.2% and benzoyl peroxide 3.75% (Clindamycin-BP 3.75%)…”
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Actinic Keratosis: Current Therapies and Insights Into New Treatments by Hashim, Peter W., Chen, Tinley, Rigel, Darrell, Bhatia, Neal, Kircik, Leon H.

“…Actinic keratosis (AK) develops on chronically sun-exposed skin and constitutes one of the most common diseases managed by dermatologists. The incidence of AKs…”
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Doxycycline and minocycline for the management of acne: a review of efficacy and safety with emphasis on clinical implications by Kircik, Leon H

“…A significant number of patients with moderate-to-severe inflammatory acne are candidates for oral antibiotic therapy. Use of tetracycline for acne has yielded…”
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