Search Results - "Kirchweger, Benjamin"

A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans by Zwirchmayr, Julia, Kirchweger, Benjamin, Lehner, Theresa, Tahir, Ammar, Pretsch, Dagmar, Rollinger, Judith M.

“…In this study a robust, whole organism screening based on Caenorhabditis elegans is presented for the discovery of natural products (NP) with beneficial…”
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Pharmacological in vitro profiling of Buddleja officinalis flower extracts in the context of dry eye disease by Areesanan, Alexander, Wasilewicz, Andreas, Kirchweger, Benjamin, Nicolay, Sven, Zimmermann-Klemd, Amy, Grienke, Ulrike, Rollinger, Judith M., Gründemann, Carsten

“…Dry eye disease (DED) is caused by inflammation on the ocular surface and insufficient quality or production of the tear film. Due to various harmful…”
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Workflow for Segmentation of Caenorhabditis elegans from Fluorescence Images for the Quantitation of Lipids by Lehner, Theresa, Pum, Dietmar, Rollinger, Judith M., Kirchweger, Benjamin

“…The small and transparent nematode Caenorhabditis elegans is increasingly employed for phenotypic in vivo chemical screens. The influence of compounds on worm…”
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Azepine-Indole Alkaloids From Psychotria nemorosa Modulate 5-HT2A Receptors and Prevent in vivo Protein Toxicity in Transgenic Caenorhabditis elegans by Kirchweger, Benjamin, Klein-Junior, Luiz C., Pretsch, Dagmar, Chen, Ya, Cretton, Sylvian, Gasper, André L., Heyden, Yvan Vander, Christen, Philippe, Kirchmair, Johannes, Henriques, Amélia T., Rollinger, Judith M.

“…Nemorosine A ( 1 ) and fargesine ( 2 ), the main azepine-indole alkaloids of Psychotria nemorosa , were explored for their pharmacological profile on…”
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Expanding the Biological Properties of Alkannins and Shikonins: Their Impact on Adipogenesis and Life Expectancy in Nematodes by Arampatzis, Athanasios S., Tsave, Olga, Kirchweger, Benjamin, Zwirchmayr, Julia, Papageorgiou, Vassilios P., Rollinger, Judith M., Assimopoulou, Andreana N.

“…Alkannin, shikonin (A/S) and their derivatives are naturally occurring hydroxynaphthoquinones biosynthesized in some species of the Boraginaceae family. These…”
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Discovery of anti-SARS-CoV-2 secondary metabolites from the heartwood of Pterocarpus santalinus using multi-informative molecular networking by Wasilewicz, Andreas, Zwirchmayr, Julia, Kirchweger, Benjamin, Bojkova, Denisa, Cinatl, Jr, Jindrich, Rabenau, Holger F, Rollinger, Judith M, Beniddir, Mehdi A, Grienke, Ulrike

“…A pigment-depleted extract from the heartwood of L. f. (PS-DE) showed promising anti-SARS-CoV-2 activity with an IC of 29.9 μg/mL in Caco-2-F03 cells. To…”
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In Silico Workflow for the Discovery of Natural Products Activating the G Protein-Coupled Bile Acid Receptor 1 by Kirchweger, Benjamin, Kratz, Jadel M, Ladurner, Angela, Grienke, Ulrike, Langer, Thierry, Dirsch, Verena M, Rollinger, Judith M

“…The G protein-coupled bile acid receptor (GPBAR1) has been recognized as a promising new target for the treatment of diverse diseases, including obesity, type…”
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The role of Caenorhabditis elegans in the discovery of natural products for healthy aging by Kirchweger, Benjamin, Zwirchmayr, Julia, Grienke, Ulrike, Rollinger, Judith M

“…Covering: 2012 to 2023The human population is aging. Thus, the greatest risk factor for numerous diseases, such as diabetes, cancer and neurodegenerative…”
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Combining the Strengths of MS and NMR in Biochemometrics: A Case Study on Buddleja officinalis by Wasilewicz, Andreas, Areesanan, Alexander, Kirchweger, Benjamin, Nicolay, Sven, Waltenberger, Eva, Beniddir, Mehdi A., Gründemann, Carsten, Rollinger, Judith M., Grienke, Ulrike

“…Biochemometrics has emerged as promising strategy for the targeted identification of bioactive constituents from natural sources. It is based on the…”
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Molecular networking unveils anti-SARS-CoV-2 constituents from traditionally used remedies by Wasilewicz, Andreas, Bojkova, Denisa, Beniddir, Mehdi A., Cinatl, Jindrich, Rabenau, Holger F., Grienke, Ulrike, Rollinger, Judith M., Kirchweger, Benjamin

“…Plants and fungi have a long tradition in ethnopharmacology for the treatment of infectious diseases including viruses. Many of these natural products have…”
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In Silico and In Vitro Approach to Assess Direct Allosteric AMPK Activators from Nature by Kirchweger, Benjamin, Wasilewicz, Andreas, Fischhuber, Katrin, Tahir, Ammar, Chen, Ya, Heiss, Elke H, Langer, Thierry, Kirchmair, Johannes, Rollinger, Judith M

“…The 5'-adenosine monophosphate-activated protein kinase (AMPK) is an important metabolic regulator. Its allosteric drug and metabolite binding (ADaM) site was…”
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Identification of Natural Products Inhibiting SARS-CoV‑2 by Targeting Viral Proteases: A Combined in Silico and in Vitro Approach by Wasilewicz, Andreas, Kirchweger, Benjamin, Bojkova, Denisa, Abi Saad, Marie Jose, Langeder, Julia, Bütikofer, Matthias, Adelsberger, Sigrid, Grienke, Ulrike, Cinatl Jr, Jindrich, Petermann, Olivier, Scapozza, Leonardo, Orts, Julien, Kirchmair, Johannes, Rabenau, Holger F., Rollinger, Judith M.

“…In this study, an integrated in silico–in vitro approach was employed to discover natural products (NPs) active against SARS-CoV-2. The two SARS-CoV-2 viral…”
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Azepine-Indole Alkaloids From Psychotria nemorosa Modulate 5-HT 2 A Receptors and Prevent in vivo Protein Toxicity in Transgenic Caenorhabditis elegans by Kirchweger, Benjamin, Klein-Junior, Luiz C, Pretsch, Dagmar, Chen, Ya, Cretton, Sylvian, Gasper, André L, Heyden, Yvan Vander, Christen, Philippe, Kirchmair, Johannes, Henriques, Amélia T, Rollinger, Judith M

“…Nemorosine A ( ) and fargesine ( ), the main azepine-indole alkaloids of , were explored for their pharmacological profile on neurodegenerative disorders (NDs)…”
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Steroid sulfatase inhibiting lanostane triterpenes – Structure activity relationship and in silico insights by Grienke, Ulrike, Kaserer, Teresa, Kirchweger, Benjamin, Lambrinidis, George, Kandel, Ralph T., Foster, Paul A., Schuster, Daniela, Mikros, Emmanuel, Rollinger, Judith M.

“…[Display omitted] •Three pharmacophore models were developed to identify STS inhibitors from natural sources.•SARs were derived from 18 isolated lanostane-type…”
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