Search Results - "Kirchhoff, Aaron"
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The FKBP5 Gene Affects Alcohol Drinking in Knockout Mice and Is Implicated in Alcohol Drinking in Humans
Published in International journal of molecular sciences (05-08-2016)“…FKBP5 encodes FK506-binding protein 5, a glucocorticoid receptor (GR)-binding protein implicated in various psychiatric disorders and alcohol withdrawal…”
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Journal Article -
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Evaluation of Difluoromethyl Ketones as Agonists of the γ‑Aminobutyric Acid Type B (GABAB) Receptor
Published in Journal of medicinal chemistry (28-03-2013)“…The design, synthesis, biological evaluation, and in vivo studies of difluoromethyl ketones as GABAB agonists that are not structurally analogous to known…”
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3
Quantitative LC–MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor
Published in Analytical biochemistry (15-01-2013)“…An additional class of endogenous lipid amides, N-arachidonoyl amino acids (Ara-AAs), is growing in significance in the field of endocannabinoids. The…”
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Journal Article -
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FKBP5 Moderates Alcohol Withdrawal Severity: Human Genetic Association and Functional Validation in Knockout Mice
Published in Neuropsychopharmacology (New York, N.Y.) (01-07-2014)“…Alcohol withdrawal is associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The FKBP5 gene codes for a co-chaperone, FK506-binding protein 5,…”
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Chronic Exposure to the Combination of Cigarette Smoke and Morphine Decreases CD4 + Regulatory T Cell Numbers by Reprogramming the Treg Cell Transcriptome
Published in Frontiers in immunology (20-04-2022)“…There is a high incidence of tobacco use among intravenous opioid drug users. It is well established that opioids and tobacco smoke induce a degree of immune…”
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Prevention of vaginal and rectal HIV transmission by antiretroviral combinations in humanized mice
Published in PloS one (07-09-2017)“…With more than 7,000 new HIV infections daily worldwide, there is an urgent need for non-vaccine biomedical prevention (nBP) strategies that are safe,…”
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Relation between corticosterone and fear-related behavior in mice selectively bred for high or low alcohol preference
Published in Addiction biology (01-07-2014)“…Blunted cortisol responses to stress or trauma have been linked with genetic (familial) risk for both alcoholism and post‐traumatic stress disorder (PTSD)…”
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Endocannabinoids and Fear-Related Behavior in Mice Selectively Bred for High or Low Alcohol Preference
Published in Brain sciences (26-09-2019)“…Alcohol use disorders (AUDs) have a high incidence of co-morbidity with stress-related psychopathologies, such as post-traumatic stress disorder (PTSD)…”
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Cigarette Smoke and Morphine Promote Treg Plasticity to Th17 via Enhancing Trained Immunity
Published in Cells (Basel, Switzerland) (01-09-2022)“…CD4 regulatory T cells (Tregs) respond to environmental cues to permit or suppress inflammation, and atherosclerosis weakens Treg suppression and promotes…”
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Protection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice
Published in The open virology journal (2018)“…In the absence of a vaccine, there is an urgent need for the identification of effective agents that prevent HIV transmission in uninfected individuals…”
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The effect of length of listening example on preference ratings of sixth-grade general music students
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Dissertation -
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The effect of length of listening example on preference ratings of sixth-grade general music students
Published 01-01-2002“…The purpose of this study was to determine if the length of a listening example used in the music classroom affects a student's attitude or preference towards…”
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Dissertation