Search Results - "Kirchgessner, Henning"

LFA-1 cluster formation in T-cells depends on l-plastin phosphorylation regulated by P90RSK and PP2A by Wabnitz, Guido H., Honus, Sibylle, Habicht, Jüri, Orlik, Christian, Kirchgessner, Henning, Samstag, Yvonne

“…The integrin LFA-1 is crucial for T-cell/ APC interactions and sensitive recognition of antigens. Precise nanoscale organization and valency regulation of…”
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Spatial oxidation of L-plastin downmodulates actin-based functions of tumor cells by Balta, Emre, Hardt, Robert, Liang, Jie, Kirchgessner, Henning, Orlik, Christian, Jahraus, Beate, Hillmer, Stefan, Meuer, Stefan, Hübner, Katrin, Wabnitz, Guido H., Samstag, Yvonne

“…Several antitumor therapies work by increasing reactive oxygen species (ROS) within the tumor micromilieu. Here, we reveal that L-plastin (LPL), an established…”
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Comparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells by Lairikyengbam, Divya, Wetterauer, Bernhard, Schmiech, Michael, Jahraus, Beate, Kirchgessner, Henning, Wetterauer, Pille, Berschneider, Karina, Beier, Verena, Niesler, Beate, Balta, Emre, Samstag, Yvonne

“…Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by…”
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Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment by Balta, Emre, Janzen, Nina, Kirchgessner, Henning, Toufaki, Vasiliki, Orlik, Christian, Liang, Jie, Lairikyengbam, Divya, Abken, Hinrich, Niesler, Beate, Müller-Decker, Karin, Ruppert, Thomas, Samstag, Yvonne

“…Use of chimeric antigen receptor (CAR) T cells to treat B cell lymphoma and leukemia has been remarkably successful. Unfortunately, the therapeutic efficacy of…”
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InFlow microscopy of human leukocytes: A tool for quantitative analysis of actin rearrangements in the immune synapse by Wabnitz, Guido H., Nessmann, Anja, Kirchgessner, Henning, Samstag, Yvonne

“…The actin cytoskeleton is a main component to preserve the cell shape. It represents a cellular machinery that enables morphological changes and orchestrates…”
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Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin by Wabnitz, Guido H, Lohneis, Philipp, Kirchgessner, Henning, Jahraus, Beate, Gottwald, Susan, Konstandin, Mathias, Klemke, Martin, Samstag, Yvonne

“…Formation of immune synapses (IS) between T cells and APC requires multiple rearrangements in the actin cytoskeleton and selective receptor accumulation in…”
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Metastasis of prostate cancer and melanoma cells in a preclinical in vivo mouse model is enhanced by L-plastin expression and phosphorylation by Riplinger, Selina M, Wabnitz, Guido H, Kirchgessner, Henning, Jahraus, Beate, Lasitschka, Felix, Schulte, Bianca, van der Pluijm, Gabri, van der Horst, Geertje, Hämmerling, Günter J, Nakchbandi, Inaam, Samstag, Yvonne

“…Tumor cell migration and metastasis require dynamic rearrangements of the actin cytoskeleton. Interestingly, the F-actin cross-linking and stabilizing protein…”
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Imaging Flow Cytometry for Multiparametric Analysis of Molecular Mechanism Involved in the Cytotoxicity of Human CD8 + T-cells: M EASUREMENT OF C YTOTOXICITY BY I MAGING F LOW C YTOMETRY by Wabnitz, Guido H., Kirchgessner, Henning, Samstag, Yvonne

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Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry by Wabnitz, Guido, Kirchgessner, Henning, Samstag, Yvonne

“…The immune synapse is the area of communication between T cells and antigen-presenting cells (APCs). T cells polarize surface receptors and proteins towards…”
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Imaging Flow Cytometry for Multiparametric Analysis of Molecular Mechanism Involved in the Cytotoxicity of Human CD8+ T‐cells by Wabnitz, Guido H., Kirchgessner, Henning, Samstag, Yvonne

“…ABSTRACT The clearance of tumors or virus infected cells is a crucial task of the immune system. Cytotoxic T‐cells (CTLs) are able to detect and to kill such…”
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Protein Phosphatase 1α and Cofilin Regulate Nuclear Translocation of NF-κB and Promote Expression of the Anti-Inflammatory Cytokine Interleukin-10 by T Cells by Wabnitz, Guido H., Kirchgessner, Henning, Jahraus, Beate, Umansky, Ludmila, Shenolikar, Shirish, Samstag, Yvonne

“…While several protein serine/threonine kinases control cytokine production by T cells, the roles of serine/threonine phosphatases are largely unexplored. Here,…”
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Oxidation of Cofilin Mediates T Cell Hyporesponsiveness under Oxidative Stress Conditions by Klemke, Martin, Wabnitz, Guido H., Funke, Faustina, Funk, Beate, Kirchgessner, Henning, Samstag, Yvonne

“…Oxidative stress leads to impaired T cell activation. A central integrator of T cell activation is the actin-remodelling protein cofilin. Cofilin is activated…”
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Qualitative and quantitative analysis of PMN/T-cell interactions by InFlow and super-resolution microscopy by Balta, Emre, Stopp, Julian, Castelletti, Laura, Kirchgessner, Henning, Samstag, Yvonne, Wabnitz, Guido H.

“…•Transdifferentiated human PMN form immune synapses with T-cells.•A work flow to analyse PMN/T-cell interactions is provided.•F-actin is more dynamic at the…”
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LFA-1 cluster formation in T-cells depends on L-plastin phosphorylation regulated by P90 RSK and PP2A by Wabnitz, Guido H, Honus, Sibylle, Habicht, Jüri, Orlik, Christian, Kirchgessner, Henning, Samstag, Yvonne

“…The integrin LFA-1 is crucial for T-cell/ APC interactions and sensitive recognition of antigens. Precise nanoscale organization and valency regulation of…”
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L‐plastin phosphorylation: A novel target for the immunosuppressive drug dexamethasone in primary human T cells by Wabnitz, Guido H., Michalke, Felix, Stober, Christoph, Kirchgessner, Henning, Jahraus, Beate, van den Boomen, Dick J. H., Samstag, Yvonne

“…Activation of naïve T cells requires costimulation via TCR/CD3 plus accessory receptors, which enables the dynamic rearrangement of the actin cytoskeleton and…”
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Molecular Cloning of SKAP55, a Novel Protein That Associates with the Protein Tyrosine Kinase p59 fyn in Human T-lymphocytes by Marie-Cardine, Anne, Bruyns, Eddy, Eckerskorn, Christoph, Kirchgessner, Henning, Meuer, Stefan C., Schraven, Burkhart

“…In human T-lymphocytes the Src family protein tyrosine kinase p59 fyn associates with three phosphoproteins of 43, 55, and 85 kDa (pp43, pp55, and pp85)…”
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A Reducing Milieu Renders Cofilin Insensitive to Phosphatidylinositol 4,5-Bisphosphate (PIP2) Inhibition by Schulte, Bianca, John, Isabel, Simon, Bernd, Brockmann, Christoph, Oelmeier, Stefan A., Jahraus, Beate, Kirchgessner, Henning, Riplinger, Selina, Carlomagno, Teresa, Wabnitz, Guido H., Samstag, Yvonne

“…Oxidative stress can lead to T cell hyporesponsiveness. A reducing micromilieu (e.g. provided by dendritic cells) can rescue T cells from such oxidant-induced…”
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Ras/PI3Kinase/cofilin-independent activation of human CD45RA⁺ and CD45RO⁺ T cells by superagonistic CD28 stimulation by Sester, Urban, Wabnitz, Guido H, Kirchgessner, Henning, Samstag, Yvonne

“…T cell activation requires costimulation of TCR/CD3 plus accessory receptors (e.g. CD28). A hallmark of costimulation is the dynamic reorganization of the…”
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Beta2-integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris by Konstandin, Mathias H., Aksoy, Hülya, Wabnitz, Guido H., Volz, Christian, Erbel, Christian, Kirchgessner, Henning, Giannitsis, Evangelos, Katus, Hugo A., Samstag, Yvonne, Dengler, Thomas J.

“…Background Cardiac troponins provide excellent risk stratification in unstable angina (UA), but no reliable markers are available in troponin-negative…”
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T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane by Bruyns, E, Marie-Cardine, A, Kirchgessner, H, Sagolla, K, Shevchenko, A, Mann, M, Autschbach, F, Bensussan, A, Meuer, S, Schraven, B

“…The molecular mechanisms regulating recruitment of intracellular signaling proteins like growth factor receptor-bound protein 2 (Grb2), phospholipase Cgamma1,…”
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