Search Results - "Kircher, Brigitte"

A New Approach in Cancer Treatment: Discovery of Chlorido[N,N′‑disalicylidene-1,2-phenylenediamine]­iron(III) Complexes as Ferroptosis Inducers by Sagasser, Jessica, Ma, Benjamin N, Baecker, Daniel, Salcher, Stefan, Hermann, Martin, Lamprecht, Julia, Angerer, Stefanie, Obexer, Petra, Kircher, Brigitte, Gust, Ronald

“…Chlorido­[N,N′-disalicylidene-1,2-phenylenediamine]­iron­(III) complexes generate lipid-based ROS and induce ferroptosis in leukemia and neuroblastoma cell…”
Get full text

Investigations on the Influence of the Axial Ligand in [Salophene]iron(III) Complexes on Biological Activity and Redox Behavior by Descher, Hubert, Strich, Sophie Luise, Hermann, Martin, Enoh, Peter, Kircher, Brigitte, Gust, Ronald

“…The [ -disalicylidene-1,2-phenylenediamine]iron(III) ([salophene]iron(III)) derivatives - with anionic axial ligands (A = Cl , NO , SCN , CH COO ) and…”
Get full text

Cytotoxic diterpenoids from Salvia glutinosa and comparison with the tanshinone profile of danshen ( Salvia miltiorrhiza ) by Ayvazyan, Arpine, Deutsch, Lenard, Zidorn, Christian, Kircher, Brigitte, Çiçek, Serhat S

“…The roots of are the source of the traditional Chinese medicine danshen and the class of tanshinones, particular quinoid -diterpenoids of the abietane type. Of…”
Get full text

The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors by Tien Anh, Duong, Hai Nam, Nguyen, Kircher, Brigitte, Baecker, Daniel

“…In recent years, histone deacetylases (HDACs) have emerged as promising targets in the treatment of cancer. The approach is to inhibit HDACs with drugs known…”
Get full text

Design, synthesis, and biological evaluation of novel halogenated chlorido[N,N′-bis(salicylidene)-1,2-bis(3-methoxyphenyl)ethylenediamine]iron(III) complexes as anticancer agents by Bernkop-Schnürch, Astrid Dagmar, Huber, Klaus, Clauser, Armida, Cziferszky, Monika, Leitner, Daniel, Talasz, Heribert, Hermann, Martin, Hohloch, Stephan, Gust, Ronald, Kircher, Brigitte

“…Iron(III) complexes based on N,N ´-bis(salicylidene)ethylenediamine (salene) scaffolds have demonstrated promising anticancer features like induction of…”
Get full text

Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia by Jöhrer, Karin, Galarza Pérez, Mayra, Kircher, Brigitte, Çiçek, Serhat Sezai

“…Phenolic plant constituents are well known for their health-promoting and cancer chemopreventive properties, and products containing such constituents are…”
Get full text

Targeting NAD immunometabolism limits severe graft-versus-host disease and has potent antileukemic activity by Gerner, Romana R., Macheiner, Sophie, Reider, Simon, Siegmund, Kerstin, Grabherr, Felix, Mayr, Lisa, Texler, Bernhard, Moser, Patrizia, Effenberger, Maria, Schwaighofer, Hubert, Moschen, Alexander R., Kircher, Brigitte, Oberacher, Herbert, Zeiser, Robert, Tilg, Herbert, Nachbaur, David

“…Acute graft-versus-host disease (aGVHD) and tumor relapse remain major complications after allogeneic hematopoietic stem cell transplantation. Alloreactive T…”
Get full text

Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function by Tymoszuk, Piotr, Nairz, Manfred, Brigo, Natascha, Petzer, Verena, Heeke, Simon, Kircher, Brigitte, Hermann-Kleiter, Natascha, Klepsch, Victoria, Theurl, Igor, Weiss, Günter, Pfeifhofer-Obermair, Christa

“…Iron is both, an essential compound for many metabolic processes, and iron deficiency can impact on the proliferation of cells including lymphocytes but also…”
Get full text

Benzimidazole-Based NHC Metal Complexes as Anticancer Drug Candidates: Gold(I) vs. Platinum(II) by Kapitza, Paul, Grabher, Patricia, Scherfler, Amelie, Wurst, Klaus, Kircher, Brigitte, Gust, Ronald, Varbanov, Hristo P.

“…Herein, we present a comparative study on the chemistry and biological activity of N-heterocyclic carbene (NHC)Pt(II)/Au(I) complexes. Accordingly,…”
Get full text

Fluorinated Fe(III) Salophene Complexes: Optimization of Tumor Cell Specific Activity and Utilization of Fluorine Labeling for in Vitro Analysis by Würtenberger, Irene, Follia, Valeria, Lerch, Fanni, Cwikla, Christiane, Fahrner, Nathalie, Kalchschmidt, Christina, Flögel, Brigitte, Kircher, Brigitte, Gust, Ronald

“…Fluorine-substituted iron(III) salophene complexes (salophene = N,N′-bis(salicylidene)-1,2-phe­nyl­ene­di­amine) were synthesized and evaluated for biological…”
Get full text

Transferrin Receptor-Mediated Cellular Uptake of Fluorinated Chlorido[N,N′‑bis(salicylidene)-1,2-phenylenediamine]iron(III) Complexes by Bernkop-Schnürch, Astrid Dagmar, Hermann, Martin, Leitner, Daniel, Talasz, Heribert, Descher, Hubert Aaron, Hohloch, Stephan, Gust, Ronald, Kircher, Brigitte

“…Fluorinated chlorido­[salophene]­iron­(III) complexes (salophene = N,N′-bis­(salicylidene)-1,2-phenylenediamine) are promising anticancer agents. Apoptosis and…”
Get full text

PBRM1 mutations might render a subtype of biliary tract cancers sensitive to drugs targeting the DNA damage repair system by Zimmer, Kai, Kocher, Florian, Untergasser, Gerold, Kircher, Brigitte, Amann, Arno, Baca, Yasmine, Xiu, Joanne, Korn, W. Micheal, Berger, Martin D., Lenz, Heinz-Josef, Puccini, Alberto, Fontana, Elisa, Shields, Anthony F., Marshall, John L., Hall, Michael, El-Deiry, Wafik S., Hsiehchen, David, Macarulla, Teresa, Tabernero, Josep, Pichler, Renate, Khushman, Moh’d, Manne, Upender, Lou, Emil, Wolf, Dominik, Sokolova, Viktorija, Schnaiter, Simon, Zeimet, Alain G., Gulhati, Pat, Widmann, Gerlig, Seeber, Andreas

“…Polybromo-1 ( PBRM1 ) loss of function mutations are present in a fraction of biliary tract cancers (BTCs). PBRM1 , a subunit of the PBAF chromatin-remodeling…”
Get full text

Synthesis and Pharmacological Evaluation of 1H-Imidazoles as Ligands for the Estrogen Receptor and Cytotoxic Inhibitors of the Cyclooxygenase by Wiglenda, Thomas, Ott, Ingo, Kircher, Brigitte, Schumacher, Petra, Schuster, Daniela, Langer, Thierry, Gust, Ronald

“…The 1H-imidazoles 7a−e were synthesized and tested for biological activity in vitro. The results pointed to a clear structure−activity relationship. The…”
Get full text

Phenotype frequencies of autosomal minor histocompatibility antigens display significant differences among populations by Spierings, Eric, Hendriks, Matthijs, Absi, Léna, Canossi, Angelica, Chhaya, Sonal, Crowley, John, Dolstra, Harry, Eliaou, Jean-François, Ellis, Tom, Enczmann, Jürgen, Fasano, Maria E, Gervais, Thibaut, Gorodezky, Clara, Kircher, Brigitte, Laurin, David, Leffell, Mary S, Loiseau, Pascale, Malkki, Mari, Markiewicz, Miroslaw, Martinetti, Miryam, Maruya, Etsuko, Mehra, Narinder, Oguz, Fatma, Oudshoorn, Machteld, Pereira, Noemi, Rani, Rajni, Sergeant, Ruhena, Thomson, Jackie, Tran, Thuong Hien, Turpeinen, Hannu, Yang, Kuo-Liang, Zunec, Renata, Carrington, Mary, de Knijff, Peter, Goulmy, Els

“…Minor histocompatibility (H) antigens are allogeneic target molecules having significant roles in alloimmune responses after human leukocyte antigen-matched…”
Get full text

Anti-leukemic activity of valproic acid and imatinib mesylate on human Ph+ ALL and CML cells in vitro by Kircher, Brigitte, Schumacher, Petra, Petzer, Andreas, Hoflehner, Elisabeth, Haun, Margot, Wolf, Anna Maria, Nachbaur, David, Gastl, Günther

“…The armamentarium of anti‐leukemic drugs has increased substantially since anti‐leukemic activities were recently found for a variety of non‐classical…”
Get full text

The neuropeptide secretoneurin acts as a direct angiogenic cytokine in vitro and in vivo by KIRCHMAIR, Rudolf, GANDER, Roland, FISCHER-COLBRIE, Reiner, KIRCHER, Brigitte, GAENZER, Hannes, WIEDERMANN, Christian J, ROPPER, Allan H, LOSORDO, Douglas W, PATSCH, Josef R, SCHRATZBERGER, Peter, EGGER, Margot, HANLEY, Allison, SILVER, Marcy, RITSCH, Andreas, MURAYAMA, Toshinori, KANEIDER, Nicole, STURM, Wolfgang, KEARNY, Marianne

“…Secretoneurin is an abundant neuropeptide of the central, peripheral, and autonomic nervous systems, located in nerve fibers characterized by a close…”
Get full text

Biological effect of mono- and dinuclear alkylamine platinum(II) compounds on human lymphoma cells by Kapp, Timo, Magnus, Krueger, Ingo, Ott, Stefanie, Steiner, Petra, Schumacher, David, Nachbaur, Günther, Gastl, Ronald, Gust, Kircher, Brigitte

“…The effects of the mononuclear chloro[meso-1,2-bis(4-fluorophenyl)ethylenediamine][hexylamine]platinum(II) chloride HACl and the dinuclear…”
Get full text

Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes by Baecker, Daniel, Obermoser, Victoria, Kirchner, Elisabeth Anna, Hupfauf, Andrea, Kircher, Brigitte, Gust, Ronald

“…The cobalt alkyne complex [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS) is an auspicious lead, which exhibits its anticancer activity mainly…”
Get more information

Development of Cytotoxic GW7604-Zeise’s Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor- Positive Tumor Cells by Grabher, Patricia, Kapitza, Paul, Hörmann, Nikolas, Scherfler, Amelie, Hermann, Martin, Zwerger, Michael, Varbanov, Hristo P., Kircher, Brigitte, Baecker, Daniel, Gust, Ronald

“…(E/Z)-3-(4-((E)-1-(4-Hydroxyphenyl)-2-phenylbut-1-enyl)­phenyl)­acrylic acid (GW7604) as a carrier was esterified with alkenols of various lengths and…”
Get full text

Correction to “Development of Cytotoxic GW7604-Zeise’s Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor-Positive Tumor Cells” by Grabher, Patricia, Kapitza, Paul, Hörmann, Nikolas, Scherfler, Amelie, Hermann, Martin, Zwerger, Michael, Varbanov, Hristo P., Kircher, Brigitte, Baecker, Daniel, Gust, Ronald

Get full text