Search Results - "Kirby, Duncan"
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Determinants of Ligand Specificity and Functional Plasticity in Type I Interferon Signaling
Published in Frontiers in immunology (07-10-2021)“…The Type I Interferon family of cytokines all act through the same cell surface receptor and induce phosphorylation of the same subset of response regulators…”
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Reply to Xiao and Galstyan: Reliable ligand discrimination involves many trade-offs
Published in Proceedings of the National Academy of Sciences - PNAS (06-08-2024)Get full text
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Proofreading does not result in more reliable ligand discrimination in receptor signaling due to its inherent stochasticity
Published in Proceedings of the National Academy of Sciences - PNAS (23-05-2023)“…Kinetic proofreading (KPR) has been used as a paradigmatic explanation for the high specificity of ligand discrimination by cellular receptors. KPR enhances…”
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With the leisure of time, kinetic proofreading can still perform reliable ligand discrimination / Reply
Published in Proceedings of the National Academy of Sciences - PNAS (06-08-2024)Get full text
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Mesoscopic Models of Cellular Signaling Reveal Strategies for Specificity in Crosstalk Signal Pathways
Published 01-01-2023“…Successful cellular signal processing strategies must be robust to stochastic fluctuations and yet sensitive to small differences between molecular signals,…”
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Dissertation -
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Pleiotropy enables specific and accurate signaling in the presence of ligand cross talk
Published 02-04-2021“…Phys. Rev. E 103, 042401 (2021) Living cells sense their environment through the binding of extra-cellular molecular ligands to cell surface receptors…”
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William Golding and Vardis Fisher: A Study in Parallels and Extensions
Published in College English (01-12-1965)Get full text
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WILLIAM GOLDING AND VARDIS FISHER
Published in College English (01-12-1965)Get full text
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William Golding and Vardis Fisher: A Study in Parallels and Extensions
Published in College English (01-12-1965)Get full text
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