Search Results - "Kirby, Beth"

Loss of maternal calcitriol reversibly alters early offspring growth and skeletal development in mice by Hartery, Sarah A, Kirby, Beth J, Walker, Emma C, Kaufmann, Martin, Jones, Glenville, St-Arnaud, René, Sims, Natalie A, Kovacs, Christopher S

“…Ablation of Cyp27b1 eliminates calcitriol but does not disturb fetal mineral homeostasis or skeletal development. However, independent of fetal genotypes,…”
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FGF23 is not required to regulate fetal phosphorus metabolism but exerts effects within 12 hours after birth by Ma, Yue, Kirby, Beth J, Fairbridge, Nicholas A, Karaplis, Andrew C, Lanske, Beate, Kovacs, Christopher S

“…Loss of fibroblast growth factor 23 (FGF23) causes hyperphosphatemia, extraskeletal calcifications, and early mortality; excess FGF23 causes hypophosphatemia…”
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Maternal loss of 24-hydroxylase causes increased intestinal calcium absorption and hypercalcemia during pregnancy but reduced skeletal resorption during lactation in mice by Maekawa, Alexandre S, Bennin, David, Hartery, Sarah A, Kirby, Beth J, Poulton, Ingrid J, St-Arnaud, René, Sims, Natalie A, Kovacs, Christopher S

“…Inactivation of 24-hydroxylase (CYP24A1) causes mild hypercalcemia in humans that becomes severe and life-threatening during pregnancy through unclear…”
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Calcitriol‐Dependent and ‐Independent Regulation of Intestinal Calcium Absorption, Osteoblast Function, and Skeletal Mineralization during Lactation and Recovery in Mice by Ryan, Brittany A., McGregor, Narelle E., Kirby, Beth J., Al‐Tilissi, Abdelkhayoum, Poulton, Ingrid J., Sims, Natalie A., Kovacs, Christopher S.

“…ABSTRACT Recovery from lactation‐induced bone loss appears to be calcitriol‐independent, since mice lacking 1‐alpha‐hydroxylase or vitamin D receptor (VDR)…”
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Murine Fetal Serum Phosphorus is Set Independent of FGF23 and PTH, Except in the Presence of Maternal Phosphate Loading by Sellars, K Berit, Ryan, Brittany A, Hartery, Sarah A, Kirby, Beth J, Kovacs, Christopher S

“…Abstract Fibroblast growth factor 23 (FGF23) appears to play no role until after birth, given unaltered phosphate and bone metabolism in Fgf23- and Klotho-null…”
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Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post‐lactation Bone Recovery in Cyp27b1 Null Mice by Gillies, Brittany R, Ryan, Brittany A, Tonkin, Brett A, Poulton, Ingrid J, Ma, Yue, Kirby, Beth J, St‐Arnaud, René, Sims, Natalie A, Kovacs, Christopher S

“…ABSTRACT We hypothesized that adaptation to calcium supply demands of pregnancy and lactation do not require calcitriol. Adult Cyp27b1 null mice lack…”
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Neither Absence Nor Excess of FGF23 Disturbs Murine Fetal-Placental Phosphorus Homeostasis or Prenatal Skeletal Development and Mineralization by Ma, Yue, Samaraweera, Manoharee, Cooke-Hubley, Sandra, Kirby, Beth J, Karaplis, Andrew C, Lanske, Beate, Kovacs, Christopher S

“…Fibroblast growth factor-23 (FGF23) controls serum phosphorus largely through actions on the kidneys to excrete phosphorus and reduce calcitriol. Although…”
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Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone by Kirby, Beth J, Ma, Yue, Martin, Heather M, Buckle Favaro, Kerri L, Karaplis, Andrew C, Kovacs, Christopher S

“…ABSTRACT Pregnancy invokes a doubling of intestinal calcium absorption whereas lactation programs skeletal resorption to provide calcium to milk. Postweaning…”
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Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions by Liu, Zhijie, Farley, Alison, Chen, Lizhen, Kirby, Beth J, Kovacs, Christopher S, Blackburn, C Clare, Manley, Nancy R

“…In mammals, parathyroid hormone (PTH) is a key regulator of extracellular calcium and inorganic phosphorus homeostasis. Although the parathyroid glands were…”
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Mineral Homeostasis in Murine Fetuses Is Sensitive to Maternal Calcitriol but Not to Absence of Fetal Calcitriol by Ryan, Brittany A, Alhani, Kamal, Sellars, K Berit, Kirby, Beth J, St‐Arnaud, René, Kaufmann, Martin, Jones, Glenville, Kovacs, Christopher S

“…ABSTRACT Vitamin D receptor (VDR) null fetuses have normal serum minerals, parathyroid hormone (PTH), skeletal morphology, and mineralization but increased…”
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Loss of 24-hydroxylated catabolism increases calcitriol and fibroblast growth factor 23 and alters calcium and phosphate metabolism in fetal mice by Bennin, David, Hartery, Sarah A, Kirby, Beth J, Maekawa, Alexandre S, St-Arnaud, René, Kovacs, Christopher S

“…Calcitriol circulates at low levels in normal human and rodent fetuses, in part due to increased 24-hydroxylation of calcitriol and 25-hydroxyvitamin D by…”
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Skeletal recovery after weaning does not require PTHrP by Kirby, Beth J, Ardeshirpour, Laleh, Woodrow, Janine P, Wysolmerski, John J, Sims, Natalie A, Karaplis, Andrew C, Kovacs, Christopher S

“…Mice lose 20% to 25% of trabecular bone mineral content (BMC) during lactation and restore it after weaning through unknown mechanisms. We found that tibial…”
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Lactating Ctcgrp Nulls Lose Twice the Normal Bone Mineral Content due to Fewer Osteoblasts and More Osteoclasts, Whereas Bone Mass Is Fully Restored After Weaning in Association With Up-Regulation of Wnt Signaling and Other Novel Genes by Collins, Jillian N, Kirby, Beth J, Woodrow, Janine P, Gagel, Robert F, Rosen, Clifford J, Sims, Natalie A, Kovacs, Christopher S

“…The maternal skeleton resorbs during lactation to provide calcium to milk and the lost mineral content is restored after weaning. The changes are particularly…”
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Spine bone mineral density increases after 6 months of exclusive lactation, even in women who keep breastfeeding by Cooke-Hubley, Sandra, Kirby, Beth J., Valcour, James E., Mugford, Gerald, Adachi, Jonathan D., Kovacs, Christopher S.

“…Summary This pilot study enrolled 31 women who had breastfed exclusively for 6 months. Lumbar and thoracic BMD increased 4 and 5%, respectively. Femoral neck…”
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Fibroblast Growth Factor-23 (FGF23) Exerts its Effects on Phosphorus Metabolism Starting 12 Hours after Birth, but not During Fetal Fevelopment by Ma, Yue, Kirby, Beth J, Lanske, Beate, Karaplis, Andrew C, Kovacs, Christopher S

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A 5% Increase in Trabecular (Spine) Bone Density Occurs in the First Six Months after Weaning (Factors Affecting Bone Formation after Breastfeeding Pilot Study [FABB-Pilot]) by Cooke-Hubley, Sandra, Kirby, Beth J, Wells, Chrissy, Mugford, Gerry, Valcour, James, Adachi, Jonathan D, Kovacs, Christopher S

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Increased Fibroblast Growth Factor-23 (FGF23) Does Not Alter Fetal-Placental Phosphorus Homeostasis or Prenatal Bone Formation and Mineralization by Ma, Yue, Kirby, Beth J, Kovacs, Christopher S

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Deletion of Fgf23 Does Not Perturb Fetal Mineral Homeostasis, Skeletal Mineral Content, Placental Phosphorus Transport or Placental Expression of FGF23 Target Genes by Samaraweera, M. Manoharee, Ma, Yue, Kirby, Beth J, Vatturi, Sri Teja, Lanske, Beate M, Kovacs, Christopher S

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FlowPilot: Shoreside Autonomy for Profiling Floats by Szuts, Zoltan, Harrison, Trevor, Curtin, Tom, Kirby, Beth, Ma, Barry

“…Over the last twenty years, profiling floats have revolutionized ocean observations with globally distributed Lagrangian arrays performing fixed vertical…”
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71 - Loss of FGF23 Does Not Alter Fetal Mineral/Bone Metabolism Except During Maternal Phosphate Loading by Sellars, K. Berit, Ryan, Brittany A., Kirby, Beth J., Kovacs, Christopher S.

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