Search Results - "Kiran, Manjari"

tRNA fragments (tRFs) guide Ago to regulate gene expression post-transcriptionally in a Dicer-independent manner by Kuscu, Canan, Kumar, Pankaj, Kiran, Manjari, Su, Zhangli, Malik, Asrar, Dutta, Anindya

“…tRNA related RNA fragments (tRFs), also known as tRNA-derived RNAs (tdRNAs), are abundant small RNAs reported to be associated with Argonaute proteins, yet…”
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Sirtuin 7 in cell proliferation, stress and disease: Rise of the Seventh Sirtuin by Kiran, Shashi, Anwar, Tarique, Kiran, Manjari, Ramakrishna, Gayatri

“…Sirtuin 7 is a member of the sirtuin family of proteins. Sirtuins were originally discovered in yeast for its role in prolonging replicative lifespan. Until…”
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Inefficient splicing of long non-coding RNAs is associated with higher transcript complexity in human and mouse by Basu, Koushiki, Dey, Anubha, Kiran, Manjari

“…Recent reports show that long non-coding RNAs (lncRNAs) have inefficient splicing and fewer alternative splice variants than mRNAs. Here, we have explored the…”
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MUNC, an Enhancer RNA Upstream from the MYOD Gene, Induces a Subgroup of Myogenic Transcripts in trans Independently of MyoD by Cichewicz, Magdalena A., Kiran, Manjari, Przanowska, Róża K., Sobierajska, Ewelina, Shibata, Yoshiyuki, Dutta, Anindya

“…MyoD upstream noncoding RNA (MUNC) initiates in the distal regulatory region (DRR) enhancer of MYOD and is formally classified as an enhancer RNA (DRR eRNA )…”
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Global versus Local Hubs in Human Protein–Protein Interaction Network by Kiran, Manjari, Nagarajaram, Hampapathalu Adimurthy

“…In this study, we have constructed tissue-specific protein–protein interaction networks for 70 human tissues and have identified three types of hubs based on…”
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CaTCH: Calculating transcript complexity of human genes by Basu, Koushiki, Dey, Anubha, Kiran, Manjari

“…The findings based on whole transcriptome sequencing suggest that alternative splicing occurs in approximately 95% of human multi-exon genes, thus, playing a…”
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Two subunits of human ORC are dispensable for DNA replication and proliferation by Shibata, Etsuko, Kiran, Manjari, Shibata, Yoshiyuki, Singh, Samarendra, Kiran, Shashi, Dutta, Anindya

“…The six-subunit Origin Recognition Complex (ORC) is believed to be an essential eukaryotic ATPase that binds to origins of replication as a ring-shaped…”
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Exosomes: Insights from Retinoblastoma and Other Eye Cancers by Lande, Kashmiri, Gupta, Jitesh, Ranjan, Ravi, Kiran, Manjari, Torres Solis, Luis Fernando, Solís Herrera, Arturo, Aliev, Gjumrakch, Karnati, Roy

“…Exosomes, considered as cell debris or garbage bags, have been later characterized as nanometer-sized extracellular double-membrane lipid bilayer bio-vesicles…”
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Sirtuin 7 Promotes Mesenchymal to Epithelial Transition by β-Catenin Redistribution and Stabilization by Kiran, Shashi, Kiran, Manjari, Ramakrishna, Gayatri

“…SIRT7 belongs to the family of “NAD+ dependent deacetylases” called Sirtuins. In the present work we report a novel role of SIRT7 in regulating cellular…”
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Integrative Analyses of Circulating Small RNAs and Kidney Graft Transcriptome in Transplant Glomerulopathy by Kuscu, Canan, Kiran, Manjari, Mohammed, Akram, Kuscu, Cem, Satpathy, Sarthak, Wolen, Aaron, Bardhi, Elissa, Bajwa, Amandeep, Eason, James D, Maluf, Daniel, Mas, Valeria, Akalin, Enver

“…Transplant glomerulopathy develops through multiple mechanisms, including donor-specific antibodies, T cells and innate immunity. This study investigates…”
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Rapamycin Alternatively Modifies Mitochondrial Dynamics in Dendritic Cells to Reduce Kidney Ischemic Reperfusion Injury by Namwanje, Maria, Bisunke, Bijay, Rousselle, Thomas V, Lamanilao, Gene G, Sunder, Venkatadri S, Patterson, Elizabeth C, Kuscu, Canan, Kuscu, Cem, Maluf, Daniel, Kiran, Manjari, Mas, Valeria, Eason, James D, Bajwa, Amandeep

“…Dendritic cells (DCs) are unique immune cells that can link innate and adaptive immune responses and Immunometabolism greatly impacts their phenotype…”
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The pan-cancer landscape of prognostic germline variants in 10,582 patients by Chatrath, Ajay, Przanowska, Roza, Kiran, Shashi, Su, Zhangli, Saha, Shekhar, Wilson, Briana, Tsunematsu, Takaaki, Ahn, Ji-Hye, Lee, Kyung Yong, Paulsen, Teressa, Sobierajska, Ewelina, Kiran, Manjari, Tang, Xiwei, Li, Tianxi, Kumar, Pankaj, Ratan, Aakrosh, Dutta, Anindya

“…While clinical factors such as age, grade, stage, and histological subtype provide physicians with information about patient prognosis, genomic data can…”
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MAGICAL: A multi-class classifier to predict synthetic lethal and viable interactions using protein-protein interaction network by Dey, Anubha, Mudunuri, Suresh, Kiran, Manjari

“…Synthetic lethality (SL) and synthetic viability (SV) are commonly studied genetic interactions in the targeted therapy approach in cancer. In SL, inhibiting…”
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Dissection of hubs and bottlenecks in a protein-protein interaction network by Nithya, Chandramohan, Kiran, Manjari, Nagarajaram, Hampapathalu Adimurthy

“…Analysis of degree centrality in conjunction with betweenness centrality of proteins in a human protein-protein interaction network revealed three categories…”
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A Prognostic Signature for Lower Grade Gliomas Based on Expression of Long Non-Coding RNAs by Kiran, Manjari, Chatrath, Ajay, Tang, Xiwei, Keenan, Daniel Macrae, Dutta, Anindya

“…Diffuse low-grade and intermediate-grade gliomas (together known as lower grade gliomas, WHO grade II and III) develop in the supporting glial cells of brain…”
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Long Noncoding RNA DRAIC Inhibits Prostate Cancer Progression by Interacting with IKK to Inhibit NF-κB Activation by Saha, Shekhar, Kiran, Manjari, Kuscu, Canan, Chatrath, Ajay, Wotton, David, Mayo, Marty W, Dutta, Anindya

“…DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castration-resistant advanced prostate cancer. Decreased DRAIC expression predicts poor patient…”
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The Germline Variants rs61757955 and rs34988193 Are Predictive of Survival in Lower Grade Glioma Patients by Chatrath, Ajay, Kiran, Manjari, Kumar, Pankaj, Ratan, Aakrosh, Dutta, Anindya

“…Lower grade gliomas are invasive brain tumors that are difficult to completely resect neurosurgically. They often recur following resection and progress,…”
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LINC00152 Promotes Invasion through a 3'-Hairpin Structure and Associates with Prognosis in Glioblastoma by Reon, Brian J, Takao Real Karia, Bruno, Kiran, Manjari, Dutta, Anindya

“…Long noncoding RNAs (lncRNA) are increasingly implicated in oncogenesis. Here, it is determined that / is upregulated in glioblastoma multiforme (GBM) and…”
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Mariner: explore the Hi-Cs by Davis, Eric S, Parker, Sarah M, Kramer, Nicole E, Flores, J P, Kiran, Manjari, Phanstiel, Douglas H

“…Abstract Motivation 3D chromatin structure plays an important role in regulating gene expression and alterations to this structure can result in developmental…”
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Chromatin loop dynamics during cellular differentiation are associated with changes to both anchor and internal regulatory features by Bond, Marielle L, Davis, Eric S, Quiroga, Ivana Y, Dey, Anubha, Kiran, Manjari, Love, Michael I, Won, Hyejung, Phanstiel, Douglas H

“…Three-dimensional (3D) chromatin structure has been shown to play a role in regulating gene transcription during biological transitions. Although our…”
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