Search Results - "Kira, J"

The structural biology of biosynthetic megaenzymes by Weissman, Kira J

“…The modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) are among the largest and most complicated enzymes in nature. In these…”
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Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology by Weissman, Kira J

“…Multienzyme polyketide synthases (PKSs) are molecular-scale assembly lines which construct complex natural products in bacteria. The underlying modular…”
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Uncovering the structures of modular polyketide synthases by Weissman, Kira J

“…The modular polyketide synthases (PKSs) are multienzyme proteins responsible for the assembly of diverse secondary metabolites of high economic and therapeutic…”
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Myxobacterial secondary metabolites: bioactivities and modes-of-action by Weissman, Kira J, Müller, Rolf

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A Meta-Analysis of the Efficacy of Teaching Mathematics with Concrete Manipulatives by Carbonneau, Kira J, Marley, Scott C, Selig, James P

“…The use of manipulatives to teach mathematics is often prescribed as an efficacious teaching strategy. To examine the empirical evidence regarding the use of…”
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Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals by Stanzick, Kira J., Li, Yong, Schlosser, Pascal, Gorski, Mathias, Wuttke, Matthias, Thomas, Laurent F., Rasheed, Humaira, Rowan, Bryce X., Graham, Sarah E., Vanderweff, Brett R., Patil, Snehal B., Robinson-Cohen, Cassiane, Gaziano, John M., O’Donnell, Christopher J., Willer, Cristen J., Hallan, Stein, Åsvold, Bjørn Olav, Gessner, Andre, Hung, Adriana M., Pattaro, Cristian, Köttgen, Anna, Stark, Klaus J., Heid, Iris M., Winkler, Thomas W.

“…Genes underneath signals from genome-wide association studies (GWAS) for kidney function are promising targets for functional studies, but prioritizing…”
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Polyketide stereocontrol: a study in chemical biology by Weissman, Kira J

“…The biosynthesis of reduced polyketides in bacteria by modular polyketide synthases (PKSs) proceeds with exquisite stereocontrol. As the stereochemistry is…”
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Spinal cord involvement by atrophy and associations with disability are different between multiple sclerosis and neuromyelitis optica spectrum disorder by Nakamura, Y., Liu, Z., Fukumoto, S., Shinoda, K., Sakoda, A., Matsushita, T., Hayashida, S., Isobe, N., Watanabe, M., Hiwatashi, A., Yamasaki, R., Kira, J. ‐i.

“…Background and purpose The cervical and thoracic cross‐sectional spinal cord area (CS‐SCA) in multiple sclerosis (MS) correlates with disability, whilst such a…”
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Certification systems for machine learning: Lessons from sustainability by Matus, Kira J.M., Veale, Michael

“…Concerns around machine learning’s societal impacts have led to proposals to certify some systems. While prominent governance efforts to date center around…”
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Teacher judgments of student mathematics achievement: the moderating role of student-teacher conflict by Carbonneau, Kira J.

“…Equitable assessment of students' mathematical thinking is imperative for effective instruction. This two-part study investigated teachers' judgement of…”
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Data Gap: Air Quality Networks Miss Air Pollution from Concentrated Animal Feeding Operations by Burns, Alyssa M., Chandler, Gabriel, Dunham, Kira J., Carlton, Annmarie G.

“…In the U.S., the agricultural sector is the largest controllable source of several air pollutants, including ammonia (NH3), which is a key precursor to PM2.5…”
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The Relationship Between Directly Observed Therapy for Chlamydia Infections and Retesting Rates in an Adolescent Population by Nightingale, Kira J., Makeneni, Spandana, Bonett, Stephen, Wood, Sarah M.

“…Chlamydia trachomatis is the most common reportable sexually transmitted infection in the United States, with >60% of reported cases occurring in individuals…”
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Thriving in a salty future: morpho-anatomical, physiological, and molecular adaptations to salt stress in alfalfa (Medicago sativa L.) and other crops by Liu, Xu, Elzenga, J Theo M, Venema, Jan Henk, Tiedge, Kira J

“…With soil salinity levels rising at an alarming rate, accelerated by climate change and human interventions, there is a growing need for crop varieties that…”
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Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways by Su, Li, Souaibou, Yaouba, Hôtel, Laurence, Paris, Cédric, Weissman, Kira J, Aigle, Bertrand

“…Iron is essential to many biological processes but its poor solubility in aerobic environments restricts its bioavailability. To overcome this limitation,…”
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Nurturing "A Specific Kind of Unicorn-y Teacher": How Teacher Activist Networks Influence the Professional Identity and Practices of Teachers of Color by Mawhinney, Lynnette, Baker-Doyle, Kira J.

“…This article highlights the ways justice-oriented activist teachers of Color nurture themselves professionally through their involvement in critical…”
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Engineering the stambomycin modular polyketide synthase yields 37-membered mini-stambomycins by Su, Li, Hôtel, Laurence, Paris, Cédric, Chepkirui, Clara, Brachmann, Alexander O., Piel, Jörn, Jacob, Christophe, Aigle, Bertrand, Weissman, Kira J.

“…The modular organization of the type I polyketide synthases (PKSs) would seem propitious for rational engineering of desirable analogous. However, despite…”
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From a Spark, a Mighty Flame: How Germinal Networks Support Teachers of Color to Promote Change in Activist Organizations and Beyond by Baker-Doyle, Kira J., Mawhinney, Lynnette

“…Background: Recent research has demonstrated that social justice teacher activist networks provide vital support to teachers of Color, reducing feelings of…”
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'In it together': activist teachers of color networks combating isolation by Mawhinney, Lynnette, Baker-Doyle, Kira J., Rosen, Sonia M.

“…Teachers of Color experience isolation due to racial microaggressions and institutional racism throughout their careers, leading to trauma and higher levels of…”
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Pyrrolizwilline, a unique bacterial alkaloid assembled by a nonribosomal peptide synthetase and non-enzymatic dimerization by Effert, Juliana, Westphalen, Margaretha, Calderari, Andrea, Shi, Yi-Ming, Elamri, Isam, Najah, Soumaya, Grün, Peter, Li, Yanyan, Gruez, Arnaud, Weissman, Kira J, Bode, Helge B

“…Pyrrolizidine alkaloids (PAs) are a structurally diverse group of heterocyclic specialized metabolites characterized by a core structure comprising a…”
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The association between olfactory bulb volume, cognitive dysfunction, physical disability and depression in multiple sclerosis by Yaldizli, Ö., Penner, I.-K., Yonekawa, T., Naegelin, Y., Kuhle, J., Pardini, M., Chard, D. T., Stippich, C., Kira, J.-i., Bendfeldt, K., Amann, M., Radue, E.-W., Kappos, L., Sprenger, T.

“…Background and purpose Olfactory bulb atrophy is associated with cognitive dysfunction in Parkinson's and Alzheimer's disease, and with major depression. It…”
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