Search Results - "Kippin, Tod"

Real-time measurement of small molecules directly in awake, ambulatory animals by Arroyo-Currás, Netzahualcóyotl, Somerson, Jacob, Vieira, Philip A., Ploense, Kyle L., Kippin, Tod E., Plaxco, Kevin W.

“…The development of a technology capable of tracking the levels of drugs, metabolites, and biomarkers in the body continuously and in real time would advance…”
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Real-time, aptamer-based tracking of circulating therapeutic agents in living animals by Ferguson, Brian Scott, Hoggarth, David A, Maliniak, Dan, Ploense, Kyle, White, Ryan J, Woodward, Nick, Hsieh, Kuangwen, Bonham, Andrew J, Eisenstein, Michael, Kippin, Tod E, Plaxco, Kevin W, Soh, Hyongsok Tom

“…A sensor capable of continuously measuring specific molecules in the bloodstream in vivo would give clinicians a valuable window into patients' health and…”
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Codeposition Enhances the Performance of Electrochemical Aptamer-Based Sensors by Wu, Yuyang, Shi, Jinyuan, Kippin, Tod E., Plaxco, Kevin W.

“…Electrochemical aptamer-based (EAB) sensors, a minimally invasive means of performing high-frequency, real-time measurement of drugs and biomarkers in situ in…”
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Using seconds‐resolved pharmacokinetic datasets to assess pharmacokinetic models encompassing time‐varying physiology by McDonough, Matthew H., Stocker, Sophie L., Kippin, Tod E., Meiring, Wendy, Plaxco, Kevin W.

“…Aim Pharmacokinetics have historically been assessed using drug concentration data obtained via blood draws and bench‐top analysis. The cumbersome nature of…”
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Improved calibration of electrochemical aptamer-based sensors by Downs, Alex M., Gerson, Julian, Leung, Kaylyn K., Honeywell, Kevin M., Kippin, Tod, Plaxco, Kevin W.

“…Electrochemical aptamer-based (EAB) sensors support the real-time, high frequency measurement of pharmaceuticals and metabolites in-situ in the living body,…”
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High Surface Area Electrodes Generated via Electrochemical Roughening Improve the Signaling of Electrochemical Aptamer-Based Biosensors by Arroyo-Currás, Netzahualcóyotl, Scida, Karen, Ploense, Kyle L, Kippin, Tod E, Plaxco, Kevin W

“…The electrochemical, aptamer-based (E-AB) sensor platform provides a modular approach to the continuous, real-time measurement of specific molecular targets…”
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Seconds-resolved pharmacokinetic measurements of the chemotherapeutic irinotecan in situ in the living body by Idili, Andrea, Arroyo-Currás, Netzahualcóyotl, Ploense, Kyle L., Csordas, Andrew T., Kuwahara, Masayasu, Kippin, Tod E., Plaxco, Kevin W.

“…The ability to measure drugs in the body rapidly and in real time would advance both our understanding of pharmacokinetics and our ability to optimally dose…”
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Implantable Hydrogel-Protective DNA Aptamer-Based Sensor Supports Accurate, Continuous Electrochemical Analysis of Drugs at Multiple Sites in Living Rats by Li, Shaoguang, Dai, Jun, Zhu, Man, Arroyo-Currás, Netzahualcóyotl, Li, Hongxing, Wang, Yuanyuan, Wang, Quan, Lou, Xiaoding, Kippin, Tod E., Wang, Shixuan, Plaxco, Kevin W., Li, Hui, Xia, Fan

“…The ability to track the levels of specific molecules, such as drugs, metabolites, and biomarkers, in the living body, in real time and for long durations,…”
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Electrochemical Aptamer-Based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-Controlled Drug Delivery by Dauphin-Ducharme, Philippe, Yang, Kyungae, Arroyo-Currás, Netzahualcóyotl, Ploense, Kyle L, Zhang, Yameng, Gerson, Julian, Kurnik, Martin, Kippin, Tod E, Stojanovic, Milan N, Plaxco, Kevin W

“…The electrochemical aptamer-based (E-AB) sensing platform appears to be a convenient (rapid, single-step, and calibration-free) and modular approach to measure…”
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The Use of Xenonucleic Acids Significantly Reduces the In Vivo Drift of Electrochemical Aptamer‐Based Sensors by Leung, Kaylyn K., Gerson, Julian, Emmons, Nicole, Heemstra, Jennifer M., Kippin, Tod E., Plaxco, Kevin W.

“…Electrochemical aptamer‐based sensors support the high‐frequency, real‐time monitoring of molecules‐of‐interest in vivo. Achieving this requires methods for…”
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A Biomimetic Phosphatidylcholine‐Terminated Monolayer Greatly Improves the In Vivo Performance of Electrochemical Aptamer‐Based Sensors by Li, Hui, Dauphin‐Ducharme, Philippe, Arroyo‐Currás, Netzahualcóyotl, Tran, Claire H., Vieira, Philip A., Li, Shaoguang, Shin, Christina, Somerson, Jacob, Kippin, Tod E., Plaxco, Kevin W.

“…The real‐time monitoring of specific analytes in situ in the living body would greatly advance our understanding of physiology and the development of…”
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Open Source Software for the Real-Time Control, Processing, and Visualization of High-Volume Electrochemical Data by Curtis, Samuel D, Ploense, Kyle L, Kurnik, Martin, Ortega, Gabriel, Parolo, Claudio, Kippin, Tod E, Plaxco, Kevin W, Arroyo-Currás, Netzahualcóyotl

“…Electrochemical sensors are major players in the race for improved molecular diagnostics due to their convenience, temporal resolution, manufacturing…”
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High-Affinity Aptamers for In Vitro and In Vivo Cocaine Sensing by Alkhamis, Obtin, Canoura, Juan, Wu, Yuyang, Emmons, Nicole A., Wang, Yuting, Honeywell, Kevin M., Plaxco, Kevin W., Kippin, Tod E., Xiao, Yi

“…The ability to quantify cocaine in biological fluids is crucial for both the diagnosis of intoxication and overdose in the clinic as well as investigation of…”
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A high‐precision view of intercompartmental drug transport via simultaneous, seconds‐resolved, in situ measurements in the vein and brain by Gerson, Julian, Erdal, Murat Kaan, Dauphin‐Ducharme, Philippe, Idili, Andrea, Hespanha, Joao P., Plaxco, Kevin W., Kippin, Tod E.

“…Background and Purpose The ability to measure specific molecules at multiple sites within the body simultaneously, and with a time resolution of seconds, could…”
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Discovery of early life stress interacting and sex‐specific quantitative trait loci impacting cocaine responsiveness by Bagley, Jared R., Szumlinski, Karen K., Kippin, Tod E.

“…Background and Purpose Addiction vulnerability involves complex gene X environment interactions leading to a pathological response to drugs. Identification of…”
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Histone Deacetylase 5 Epigenetically Controls Behavioral Adaptations to Chronic Emotional Stimuli by Renthal, William, Maze, Ian, Krishnan, Vaishnav, Covington, Herbert E., Xiao, Guanghua, Kumar, Arvind, Russo, Scott J., Graham, Ami, Tsankova, Nadia, Kippin, Tod E., Kerstetter, Kerry A., Neve, Rachael L., Haggarty, Stephen J., McKinsey, Timothy A., Bassel-Duby, Rhonda, Olson, Eric N., Nestler, Eric J.

“…Previous work has identified alterations in histone acetylation in animal models of drug addiction and depression. However, the mechanisms which integrate…”
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Replication and extension of the subregion selectivity of glutamate-related changes within the nucleus accumbens associated with the incubation of cocaine-craving by Webb, Sierra M., Miller, Bailey W., Wroten, Melissa G., Sacramento, Arianne, Travis, Katherine O., Kippin, Tod E., Ben-Shahar, Osnat, Szumlinski, Karen K.

“…Cue-elicited drug-seeking behavior intensifies with the passage of time during withdrawal from drug taking and this “incubation of cocaine-craving” involves…”
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A tight squeeze: geometric effects on the performance of three-electrode electrochemical-aptamer based sensors in constrained, in vivo placements by Leung, Kaylyn K, Gerson, Julian, Emmons, Nicole, Roehrich, Brian, Verrinder, Elsi, Fetter, Lisa C, Kippin, Tod E, Plaxco, Kevin W

“…Electrochemical, aptamer-based (EAB) sensors are the first molecular monitoring technology that is (1) based on receptor binding and not the reactivity of the…”
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Estradiol increases choice of cocaine over food in male rats by Bagley, Jared R., Adams, Julia, Bozadjian, Rachel V., Bubalo, Lana, Ploense, Kyle L., Kippin, Tod E.

“…Estradiol modulates the rewarding and reinforcing properties of cocaine in females, including an increase in selection of cocaine over alternative reinforcers…”
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Introduction to Special Issue: Hormones, Sex Differences, and Drug Response by Dominguez, Juan M., Kippin, Tod E.

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