Search Results - "Kipper, Karin"

Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part I by Kruve, Anneli, Rebane, Riin, Kipper, Karin, Oldekop, Maarja-Liisa, Evard, Hanno, Herodes, Koit, Ravio, Pekka, Leito, Ivo

“…[Display omitted] •The status of validation of LC–MS methods is comprehensively reviewed.•Clarity is brought into validation-related…”
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Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES): architecture, component evaluation and applications by Savova, Guergana K, Masanz, James J, Ogren, Philip V, Zheng, Jiaping, Sohn, Sunghwan, Kipper-Schuler, Karin C, Chute, Christopher G

“…We aim to build and evaluate an open-source natural language processing system for information extraction from electronic medical record clinical free-text. We…”
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Signal Enhancement in the HPLC-ESI-MS/MS analysis of spironolactone and its metabolites using HFIP and NH4F as eluent additives by Takkis, Kalev, Aro, Rudolf, Kõrgvee, Lenne-Triin, Varendi, Heili, Lass, Jana, Herodes, Koit, Kipper, Karin

“…This paper describes an LC-MS/MS method to determine the concentration of spironolactone and its metabolites 7-alpha-methylthiospironolactone and canrenone in…”
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Plasma and CSF pharmacokinetics of meropenem in neonates and young infants: results from the NeoMero studies by Germovsek, Eva, Lutsar, Irja, Kipper, Karin, Karlsson, Mats O, Planche, Tim, Chazallon, Corine, Meyer, Laurence, Trafojer, Ursula M T, Metsvaht, Tuuli, Fournier, Isabelle, Sharland, Mike, Heath, Paul, Standing, Joseph F

“…Abstract Background Sepsis and bacterial meningitis are major causes of mortality and morbidity in neonates and infants. Meropenem, a broad-spectrum…”
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Emergence of phenotypic and genotypic antimicrobial resistance in Mycobacterium tuberculosis by Kloprogge, Frank, Ortiz Canseco, Julio, Phee, Lynette, Sadouki, Zahra, Kipper, Karin, Witney, Adam A., Stoker, Neil, McHugh, Timothy D.

“…Concentration dependency of phenotypic and genotypic isoniazid-rifampicin resistance emergence was investigated to obtain a mechanistic understanding on how…”
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Sudan black poisoning resulted in methemoglobinemia in a baby with congenital chyloperitoneum by Padari, Helgi, Kipper, Karin, Eelmäe, Imbi, Nerman, Jekaterina, Lintrop, Mare, Metsvaht, Tuuli

“…Key Clinical Message Treatment of congenital chyloperitoneum is a challenge. Conservative methods may be ineffective. Preoperative visualization of the site of…”
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Simultaneous quantification of cyclosporin, tacrolimus, sirolimus and everolimus in whole blood by UHPLC–MS/MS for therapeutic drug monitoring by Antunes, Natalicia J., Kipper, Karin, Couchman, Lewis, Duncan, Marie‐Anne, Holt, David W., De Nucci, Gilberto, Johnston, Atholl

“…The aim of this study was to develop and validate a UHPLC–MS/MS assay to quantify cyclosporin (CYC), tacrolimus (TAC), sirolimus (SIR) and everolimus (EVE) in…”
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In vitro metabolism of the new antifungal dapaconazole using liver microsomes by Antunes, Natalícia de Jesus, Coombes, Gemma, da Cunha, Kelly Francisco, Moreira, Fernanda de Lima, Pilon, Alan C., Lopes, Norberto Peporine, Costa, José Luiz da, Kipper, Karin, Couchman, Lewis, Johnston, Atholl, De Nucci, Gilberto

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Prospective Prediction of Dapaconazole Clinical Drug-Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling by Antunes, Natalícia de Jesus, Moreira, Fernanda de Lima, Kipper, Karin, Couchman, Lewis, Lebre, Daniel Temponi, Johnston, Atholl, De Nucci, Gilberto

“…This study predicted dapaconazole clinical drug−drug interactions (DDIs) over the main Cytochrome P450 (CYP) isoenzymes using static (in vitro to in vivo…”
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Short versus Long Infusion of Meropenem in Very-Low-Birth-Weight Neonates by PADARI, Helgi, METSVAHT, Tuuli, KÖRGVEE, Lenne-Triin, GERMOVSEK, Eva, ILMOJA, Mari-Liis, KIPPER, Karin, HERODES, Koit, STANDING, Joseph F, OSELIN, Kersti, LUTSAR, Irja

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Revision of the Gas-Phase Acidity Scale below 300 kcal mol−1 by Leito, Ivo, Raamat, Elin, Kütt, Agnes, Saame, Jaan, Kipper, Karin, Koppel, Ilmar A, Koppel, Ivar, Zhang, Min, Mishima, Masaaki, Yagupolskii, Lev M, Garlyauskayte, Romute Yu, Filatov, Andrey A

“…The gas-phase acidity (GA) scale from (CF3CO)2NH to (C2F5SO2)2NHabout a 24 kcal mol−1 range of gas-phase aciditieswas reexamined using the Fourier transform…”
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Population Pharmacokinetic Study of Benzylpenicillin in Critically Unwell Adults by Shah, Reya V, Kipper, Karin, Baker, Emma H, Barker, Charlotte I S, Oldfield, Isobel, Philips, Barbara J, Johnston, Atholl, Lipman, Jeffrey, Rhodes, Andrew, Basarab, Marina, Sharland, Mike, Almahdi, Sarraa, Wake, Rachel M, Standing, Joseph F, Lonsdale, Dagan O

“…Pharmacokinetics are highly variable in critical illness, and suboptimal antibiotic exposure is associated with treatment failure. Benzylpenicillin is a…”
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Liquid chromatography–tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children by Ongas, Martin, Standing, Joseph, Ogutu, Bernhards, Waichungo, Joseph, Berkley, James A., Kipper, Karin

“…We have developed and validated a novel, sensitive, selective and reproducible reversed-phase high-performance liquid chromatography method coupled with…”
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Dosing of Ertapenem in an Extreme Obesity: A Case Report of 250 kg Patient by Starkopf, Joel, Kipper, Karin, Tamme, Kadri, Lass, Jana

“…Limited available data for dosing in obesity of the medicines used in this case are discussed, with the emphasis on ertapenem. The case illustrates the…”
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Synthesis of aza-phenylalanine, aza-tyrosine, and aza-tryptophan precursors via hydrazine alkylation by Mastitski, A, Haljasorg, T, Kipper, K, Järv, J

“…Aza-amino acid precursors with an aromatic side chain were synthesized, using hydrazine alkylation. This synthetic pathway avoided use of hydrogen gas and…”
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Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part II by Kruve, Anneli, Rebane, Riin, Kipper, Karin, Oldekop, Maarja-Liisa, Evard, Hanno, Herodes, Koit, Ravio, Pekka, Leito, Ivo

“…[Display omitted] •The status of validation of LC–MS methods is comprehensively reviewed.•Clarity is brought into validation-related…”
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A UHPLC-MS/MS method to simultaneously quantify apixaban, edoxaban and rivaroxaban in human plasma and breast milk: For emerging lactation studies by Zhao, Yating, Couchman, Lewis, Kipper, Karin, Arya, Roopen, Patel, Jignesh P.

“…•How much direct oral anticoagulants (DOACs) transfer into human breast milk is unknown.•First report of an analytical method for quantification of DOACs in…”
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Retention of acidic and basic analytes in reversed phase column using fluorinated and novel eluent additives for liquid chromatography-tandem mass spectrometry by Veigure, Ruta, Lossmann, Krit, Hecht, Max, Parman, Elisabeth, Born, Rasmus, Leito, Ivo, Herodes, Koit, Kipper, Karin

“…•Introduction of 5 novel, volatile compounds as eluent additives.•Insights to retention mechanisms with ion-pairing fluorinated eluent additives.•Fluorinated…”
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Retention mechanisms of acidic and basic analytes on the Pentafluorophenyl stationary phase using fluorinated eluent additives by Lossmann, Krit, Hecht, Ruta, Saame, Jaan, Heering, Agnes, Leito, Ivo, Kipper, Karin

“…•Pentafluorophenyl stationary phase offers alternative selectivity for drug-like molecules.•A full characterisation of the pentafluorophenyl stationary phase…”
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Cocaine-induced epigenetic DNA modification in mouse addiction-specific and non-specific tissues by Anier, Kaili, Urb, Mari, Kipper, Karin, Herodes, Koit, Timmusk, Tõnis, Zharkovsky, Alexander, Kalda, Anti

“…Cocaine-related DNA methylation studies have primarily focused on the specific brain regions associated with drug addiction (e.g., the nucleus accumbens, NAc)…”
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