A seroprevalence study of poliovirus antibody against a collection of recombinant and non-recombinant poliovirus vaccine strains in the population of southern Greece

In this study, the serological status of the southern Greek population in the 1–10-year, 11–20-year, 21–30-year and 31–40-year age groups with regard to Sabin vaccine strains and a collection of 15 recombinant and four non-recombinant poliovirus vaccine strains was determined. For all three poliovir...

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Bibliographic Details
Published in:	Clinical microbiology and infection Vol. 16; no. 11; pp. 1672 - 1675
Main Authors:	Pliaka, V., Ruether, I.G.A., Kyriakopoulou, Z., Kioussi, P., Plakokefalos, E., Megalou, M., Pratti, A., Levidiotou-Stefanou, S., Markoulatos, P.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Elsevier Ltd 01-11-2010 Blackwell Publishing Ltd Wiley-Blackwell Elsevier Limited
Subjects:	Adolescent Adult Age Antibodies Antibodies, Viral - blood Biological and medical sciences Child Child, Preschool Greece Greece - epidemiology Humans Immunity Immunization Schedule Immunization, Secondary Infant Infectious diseases Medical sciences Neutralization Tests OPV derivatives Poliomyelitis - epidemiology Poliomyelitis - immunology Poliomyelitis - prevention & control Poliovirus Poliovirus - immunology Poliovirus Vaccine, Oral - administration & dosage Poliovirus Vaccine, Oral - immunology Poliovirus Vaccines - administration & dosage Poliovirus Vaccines - immunology Polioviruses Seroepidemiologic Studies Vaccination Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology Greece Europe Greece OPV derivatives immunity Polioviruses Prevalence Picornaviridae Antibody Vaccine strain Enterovirus Serology Poliovirus Epidemiology Immunity Virus Infection
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Summary:	In this study, the serological status of the southern Greek population in the 1–10-year, 11–20-year, 21–30-year and 31–40-year age groups with regard to Sabin vaccine strains and a collection of 15 recombinant and four non-recombinant poliovirus vaccine strains was determined. For all three poliovirus types, the highest neutralization test (NT) titres were observed in the 1–10-year age group, indicating a good response to vaccination. In general, the serological status of the population of southern Greece with regard to poliovirus is better for types 1 and 2 than for type 3. The presence of the lowest NT titre in the 21–30-year age group against poliovirus type 3 suggests the need for a booster dose of monovalent Sabin3 vaccine to ensure personal and herd immunity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1198-743X 1469-0691
DOI:	10.1111/j.1469-0691.2010.03188.x