Search Results - "Kious, Mark"

B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses by Lin, Pei-Yi, Sun, Lishi, Thibodeaux, Suzanne R, Ludwig, Sara M, Vadlamudi, Ratna K, Hurez, Vincent J, Bahar, Rumana, Kious, Mark J, Livi, Carolina B, Wall, Shawna R, Chen, Lieping, Zhang, Bin, Shin, Tahiro, Curiel, Tyler J

“…CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a…”
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Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice by HUREZ, Vincent, DANIEL, Benjamin J, WALL, Shawna, BRUMLIK, Michael J, SHIN, Tahiro, BIN ZHANG, CURIEL, Tyler J, LISHI SUN, LIU, Ai-Jie, LUDWIG, Sara M, KIOUS, Mark J, THIBODEAUX, Suzanne R, PANDESWARA, Srilakshmi, MURTHY, Kruthi, LIVI, Carolina B

“…Although cancer tends to affect the elderly, most preclinical studies are carried out in young subjects. In this study, we developed a melanoma-specific cancer…”
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Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL‐17 producing T cells by Sun, Lishi, Hurez, Vincent J., Thibodeaux, Suzanne R., Kious, Mark J., Liu, Aijie, Lin, Peiyi, Murthy, Kruthi, Pandeswara, Srilakshmi, Shin, Tahiro, Curiel, Tyler J.

“…Summary Regulatory T cells (Tregs) are specialized CD4+ T lymphocytes helping defend against autoimmunity and inflammation. Although age is associated with…”
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Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication by Brumlik, Michael J., Nkhoma, Standwell, Kious, Mark J., Thompson, George R., Patterson, Thomas F., Siekierka, John J., Anderson, Tim J.C., Curiel, Tyler J.

“…[Display omitted] ► RWJ68198 and RWJ67657 inhibit Plasmodium falciparum replication. ► These p38 MAPK inhibitors interfere with parasite stage differentiation…”
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TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production by Brumlik, Michael J., Pandeswara, Srilakshmi, Ludwig, Sara M., Jeansonne, Duane P., Lacey, Michelle R., Murthy, Kruthi, Daniel, Benjamin J., Wang, Rong-Fu, Thibodeaux, Suzanne R., Church, Kristina M., Hurez, Vincent, Kious, Mark J., Zhang, Bin, Alagbala, Adebusola, Xia, Xiaojun, Curiel, Tyler J.

“…•TgMAPK1 is a Toxoplasma gondii mitogen-activated protein kinase (MAPK).•It affects parasite proliferation in an IFN-γ, iNOS and MKK3-dependent…”
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B7-H1 blockade plus regulatory T cell depletion improves clinical efficacy over either strategy alone in a melanoma model (P4268) by Curiel, Tyler, Murthy, Kruthi, Kious, Mark, Sun, Lishi, Zhang, Bin, Pandaswara, Srilakshmi, Hurez, Vincent

“…Abstract Denileukin diftitox (DD) is an FDA-approved conjugate of human IL-2 + diphtheria toxin. It depletes Tregs and improves clinical and immune outcomes,…”
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Novel cancer immunotherapy using rational combinations of B7-H1 blockade, Treg depletion and estrogen receptor beta signaling (165.17) by Curiel, Tyler, Kious, Mark, Sun, Lishi, Vadlamudi, Ratna, Hurez, Vincent, Murthy, Kruthi

“…Abstract We recently showed that B7-H1 blockade in mouse models for B16 melanoma and ID8 ovarian carcinoma worked better in females versus males through…”
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Sexually dimorphic control of regulatory T cell function and autoimmunity protection through B7-H1 and estrogen signals (123.50) by Curiel, Tyler, Kious, Mark, Daniel, Benjamin, Lin, Pei, Thibodeaux, Suzanne, Vadlamudi, Ratna, Wierman, Margaret, Turka, Laurence, Zhang, Ruan, Sharpe, Arlene, Francisco, Loise, Lishi, Sun, Pandaswara, Srilakshmi, Tekmal, Rajeshwar, Hurez, Vincent

“…Abstract CD4+CD25hi regulatory T cells (Tregs) mediate peripheral tolerance and defend against autoimmunity. Among immune sexual dimorphisms, autoimmunity is…”
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Denileukin diftitox (DT) and interferon (IFN)-alpha boost numbers and maturation of a novel stimulatory CD11b+Gr-1+ cell in ovarian cancer (41.62) by Thibodeaux, Suzanne R, Shin, Tahiro, Daniel, Benjamin, Lin, Pei Yi, Livi, Carolina, Wall, Shawna, Brumlik, Michael, Kious, Mark, Jeansonne, Duane, Ludwig, Sara, Curiel, Tyler

“…Abstract CD11b+Gr-1+ cells increase in spleen, ascites and mesenteric lymph nodes in BL6 mice challenged with intraperitoneal OVA-expressing ID8 ovarian…”
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TgMAPK1 is an important virulence determinant in Toxoplasma gondii affecting stage differentiation. (129.23) by Brumlik, Michael James, Ludwig, Sara M, Pandeswara, Srilakshmi, Jeansonne, Duane P, Livi, Carolina B, Daniel, Benjamin J, Church, Kristina M, Kious, Mark J, Curiel, Tyler J

“…Abstract Toxoplasma gondii is a medically important, obligate intracellular protozoan parasite that causes significant morbidity and mortality in hosts with…”
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Interferon-alpha improves immunologic and clinical response to regulatory T cell (Treg) depletion in ovarian cancer (41.15) by Wall, Shawna, Thibodeaux, Suzanne R, Lin, Pei Yi, Kious, Mark, Jeansonne, Duane, Brumlik, Michael J, Livi, Carolina, Daniel, Benjamin J, Curiel, Tyler J

“…Abstract Treg depletion improves anti-tumor immunity but is unlikely to be curative alone. Denileukin diftitox (DT) depletes Tregs in BL6 mice and prolongs…”
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Interleukin-12 is dispensable for functional interferon (IFN)-gamma producing CD8+ cytotoxic T cells in Toxoplasma gondii infection (133.28) by Daniel, Benjamin J, Liu, AiJie, Pandeswara, Srilakshmi, Ludwig, Sara M, Brumlik, Michael J, Church, Kristina M, Kious, Mark J, Curiel, Tyler J

“…Abstract Interleukin (IL)-12 is a proinflammatory cytokine generally regarded as a master regulator of type 1 T cell mediated immunity against intracellular…”
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Sex-related differences in regulatory T cell (Treg) function and resistance to B16 melanoma in the absence of B7-H1 co-signaling (40.18) by Lin, Pei Yi, Livi, Carolina, Thibodeaux, Suzanne R, Wierman, Margaret E, Kious, Mark, Jeansonne, Duane P, Shin, Tahiro, Brumlik, Michael J, Zhang, Bin, Daniel, Benjamin J, Curiel, Tyler J

“…Abstract We tested Treg function in B7-H1-/- (KO) mice. 6-10 wk male (M) or female (F) KO and M or F wildtype (WT) had equal numbers of CD4+CD25hiFoxP3+ T…”
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