Search Results - "Kinzel, V."

Double blinded randomised controlled trial of a polylactide carbonate (Calaxo) and tricalcium phosphate (Milagro® ) composite screws for tibial fixation in ACL reconstruction by Pinczewski, L, Kinzel, V, Salmon, L, Williams, H, Linklater, J, Roe, J

“…Purpose: A recent development in biodegradable screws for ACL reconstruction is the addition of "osteoconductive" materials with the aim of stimulating bone…”
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Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry by LEHMANN, WOLF D., SCHLOSSER, ANDREAS, ERBEN, GERHARD, PIPKORN, RÜDIGER, BOSSEMEYER, DIRK, KINZEL, VOLKER

“…In view of the significance of Asn deamidation and Asp isomerization to isoAsp at certain sites for protein aging and turnover, it was desirable to challenge…”
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Influence of Myristoylation, Phosphorylation, and Deamidation on the Structural Behavior of the N-Terminus of the Catalytic Subunit of CAMP-Dependent Protein Kinase by Tholey, Andreas, Pipkorn, Rüdiger, Bossemeyer, Dirk, Kinzel, Volker, Reed, Jennifer

“…A number of isoenzymes of the catalytic subunit of cAMP-dependent protein kinase arise through posttranslational modifications of the enzyme outside the…”
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The amino terminus of PKA catalytic subunit— A site for introduction of posttranslational heterogeneities by deamidation: d-Asp2 and d-isoAsp2 containing isozymes by KINZEL, VOLKER, KÖNIG, NORBERT, PIPKORN, RÜDIGER, BOSSEMEYER, DIRK, LEHMANN, WOLF D.

“…Conserved deamidation of PKA catalytic subunit isozymes Cα and Cβ—more than 25% at Asn2 in vivo in both cases—has been shown to yield Asp2- and…”
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A conserved deamidation site at asn 2 in the catalytic subunit of mammalian cAMP‐dependent protein kinase detected by capillary LC‐MS and tandem mass spectrometry by Jedrzejewski, Paul T., Girod, Andreas, Tholey, Andreas, König, Norbert, Thullner, Sandra, Kinzel, Volker, Bossemeyer, Dirk

“…The N‐terminal sequence myr‐Gly‐Asn is conserved among the myristoylated cAPK (protein kinase A) catalytic subunit isozymes C, Cβ, and O. By capillary LC‐MS…”
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Primary Structure Elements Responsible for the Conformational Switch in the Envelope Glycoprotein gp120 from Human Immunodeficiency Virus Type 1: LPCR is a Motif Governing Folding by Reed, J., Kinzel, V.

“…The ability to undergo a particular conformational switch on moving from a polar to a less polar environment has been shown to be conserved at the CD4-binding…”
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Isoform C beta 2, an unusual form of the bovine catalytic subunit of cAMP-dependent protein kinase by Wiemann, S, Kinzel, V, Pyerin, W

“…The catalytic (C) subunit is the phosphorylating component of the cAMP-dependent protein kinase, a key element in a multitude of hormonally controlled cellular…”
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Epidermal-growth-factor-induced production of phosphatidylalcohols by HeLa cells and A431 cells through activation of phospholipase D by KASZKIN, M, SEIDLER, L, KAST, R, KINZEL, V

“…In response to epidermal growth factor (EGF), HeLa cells and A431 cells rapidly accumulate substantial amounts of phosphatidic acid (up to 0.16 and 0.2…”
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Inhibitors of the Conformational Switch Involved in CD4 Binding by the env Glycoprotein gp120 from Human Immunodeficiency Virus Type 1 (HIV1) by Reed, J, Kinzel, V

“…A 15-residue fragment within the major continuous domain of gp120 from HIV1 that can bind independently to the CD4 receptor conserves the property of behaving…”
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Evidence for Ecto-Protein Kinase Activity That Phosphorylates Kemptide in a Cyclic AMP-dependent Mode by Kübler, D, Pyerin, W, Bill, O, Hotz, A, Sonka, J, Kinzel, V

“…The heptapeptide Leu-Arg-Arg-Ala-Ser-Leu-Gly (Kemptide) is a synthetic construct of a substrate for cAMP-dependent protein kinase (PK). In this work we show…”
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Biosynthesis and membrane topography of the neural cell adhesion molecule L1 by Faissner, A., Teplow, D.B., Kübler, D., Keilhauer, G., Kinzel, V., Schachner, M.

“…The biosynthesis and membrane topography of the neural cell adhesion molecule L1 have been studied in cerebellar cell cultures by metabolic labeling and…”
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Protein kinase activity and substrates at the surface of intact HeLa cells by Kübler, D, Pyerin, W, Kinzel, V

“…Evidence is presented for the location at the surface of HeLa cells of a protein kinase capable of phosphorylating surface as well as extracellular (foreign)…”
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A conformational switch is associated with receptor affinity in peptides derived from the CD4-binding domain of gp120 from HIV 1 by Reed, J, Kinzel, V

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Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity by Engh, R A, Girod, A, Kinzel, V, Huber, R, Bossemeyer, D

“…The discovery of several hundred different protein kinases involved in highly diverse cellular signaling pathways is in stark contrast to the much smaller…”
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Substrate-Effected Release of Surface-Located Protein Kinase from Intact Cells by Kubler, Dieter, Pyerin, Walter, Burow, Erika, Kinzel, Volker

“…Protein kinase activity that is independent of cAMP has been reported to exist on the surface of intact HeLa cells. Here we report that the protein kinase…”
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Distribution of phorbol ester TPA-induced structural chromosomal aberrations in HeLa cells by Färber, B, Kinzel, V

“…In order to gain further insight into the mechanism of clastogenic action of the phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA), the localization…”
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Interference of xanthate compounds with phorbol ester TPA-induced changes of phospholipid metabolism: inhibition of prostaglandin production by Kaszkin, M, Fürstenberger, G, Kinzel, V

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Conformational analysis of PKI(5-22)amide, the active inhibitory fragment of the inhibitor protein of the cyclic AMP-dependent protein kinase by Reed, J, De Ropp, J S, Trewhella, J, Glass, D B, Liddle, W K, Bradbury, E M, Kinzel, V, Walsh, D A

“…Fourier-transform i.r. spectroscopy, 1H-n.m.r. spectroscopy and X-ray scattering were used to study the conformation and shape of the peptide PKI(5-22)amide,…”
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Phosphotransferase and substrate binding mechanism of the cAMP‐dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5‐24) by Bossemeyer, D., Engh, R.A., Kinzel, V., Ponstingl, H., Huber, R.

“…The crystal structure of the porcine heart catalytic subunit of cAMP‐dependent protein kinase in a ternary complex with the MgATP analogue MnAMP‐PNP and a…”
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Cloning of the C alpha catalytic subunit of the bovine cAMP-dependent protein kinase by Wiemann, S, Kinzel, V, Pyerin, W

“…The bovine C alpha type catalytic subunit of the cAMP-dependent protein kinase was cloned. A partial cDNA was isolated from a bovine heart cDNA library. This…”
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